Hepatitis C virus infection enhances insulin resistance induced by visceral fat accumulation

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http://www3.interscience.wiley.com/journal/121378995/abstract

Liver International

Volume 29 Issue 2, Pages 213 - 220

Published Online: 15 Aug 2008

CLINICAL STUDIES

Hepatitis C virus infection enhances insulin resistance induced by visceral fat

accumulation

Yuichiro Eguchi 1 , Toshihiko Mizuta 1 , o Ishibashi 1,2 , Yoichiro Kitajima

1,2 , Noriko Oza 1,2 , Shunya Nakashita 2 , Megumi Hara 3 , Shinji Iwane 1 ,

Hirokazu Takahashi 1 , Takumi Akiyama 1 , Keisuke Ario 1 , Yasunori Kawaguchi 1

, Tsutomu Yasutake 1 , Ryuichi Iwakiri 1 , Iwata Ozaki 1 , Akitaka Hisatomi 1 ,

Takahisa Eguchi 2 , Naofumi Ono 2 and Kazuma Fujimoto 1

1 Department of Internal Medicine, Saga Medical School, Saga, Japan

2 Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Saga, Japan

3 Department of Preventive Medicine, Saga Medical School, Saga, Japan

Correspondence

Yuichiro Eguchi, Department of Internal Medicine, Saga Medical School, 5-1-1

Nabeshima, Saga 849-8501, Japan

Tel: +81 952 34 2362

Fax: +81 952 34 2017

e-mail: eguchiyu@...

ABSTRACT

Background/Aims: To clarify the impact of visceral obesity on hepatitis C virus

(HCV)-infected patients, we examined the relationship between insulin resistance

development and visceral fat accumulation.

Methods: We analyzed 87 HCV-infected patients with mild fibrosis (stage 1 or 2)

in comparison with 125 sex- and age-matched patients with non-alcoholic fatty

liver disease (NAFLD). The degree of visceral fat area (VFA; cm2) at the

umbilical level was measured by abdominal computed tomography and divided into

two grades: no visceral obesity, VFA