Risk for renal cell carcinoma in chronic hepatitis C infection

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Risk for renal cell carcinoma in chronic hepatitis C infection

Monday, 05 April 2010

Division of Gastroenterology and Hepatology, and Departments of Urology and

Biostatistics and Research Epidemiology, Henry Ford Hospital; and Wayne State

University School of Medicine, Detroit, Michigan.

Chronic infection with hepatitis C virus (HCV) confers increased risk for

chronic renal disease, and numerous reports suggest an association with renal

cell carcinoma (RCC), a cancer with rapidly rising global incidence. We sought

to determine whether HCV infection confers an increased risk for developing RCC.

With the use of administrative data from a large, integrated, and ethnically

diverse healthcare system, we did a cohort study of 67,063 HCV-tested patients

between 1997 and 2006 who were followed for the development of RCC until April

2008.

A search of the health system cancer registry for patients with the diagnosis of

kidney cancer showed that RCC was diagnosed in 0.6% (17 of 3,057) of

HCV-positive patients versus 0.3% (177 of 64,006) of HCV-negative patients. The

mean age at RCC diagnosis was much younger in HCV-positive individuals (54

versus 63; P < 0.001). The univariate hazard ratio for RCC among HCV patients

was 2.20 (95% confidence interval, 1.32-3.67; P = 0.0025). In a multivariate

model that included the risk factors age, African-American race, male gender,

and chronic kidney disease, the overall hazard ratio for RCC among HCV patients

was 1.77 (95% confidence interval, 1.05-2.98; P = 0.0313).

Chronic HCV infection confers a risk for the development of RCC. Impact:

Clinicians should consider newly identified renal lesions in patients with

chronic HCV infection with a heightened suspicion for neoplasm, and newly

diagnosed cases of RCC may require more careful surveillance for the presence of

HCV infection. Additional studies are required to confirm these findings and to

explore potential mechanisms of oncogenesis.

Written by:

Gordon SC, Moonka D, Brown KA, C, Huang MA, Bhatt N, Lamerato L.

Reference:

Cancer Epidemiol Biomarkers Prev. 2010 Mar 23. Epub ahead of print.

PubMed Abstract

PMID:20332260

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