Re: Can you help me find a study???

[Guest guest]

Dear Cheryl,

You said:

<< Hi all. I need to find the study that I believe Maura(???) mentioned to

me on the effects Buspar has on the bodies ability to metabolize Effexor.

She had said that it blocks the enzymes necessary to metabolize effexor. I

need to know if anyone can help me find the scientific study or SOME kind of

proof of this.>>

Check your email from Feb. 25 onward. I sent you this info a while ago.

I'll put it together again if I have to do so; it would save me some time if

you could find it. I don't know whether I sent it to you privately or on the

list.

Regards,

[Guest guest]

Dear Cheryl,

You said:

<< Hi all. I need to find the study that I believe Maura(???) mentioned to

me on the effects Buspar has on the bodies ability to metabolize Effexor.

She had said that it blocks the enzymes necessary to metabolize effexor. I

need to know if anyone can help me find the scientific study or SOME kind of

proof of this.>>

Check your email from Feb. 25 onward. I sent you this info a while ago.

I'll put it together again if I have to do so; it would save me some time if

you could find it. I don't know whether I sent it to you privately or on the

list.

Regards,

[Guest guest]

Cheryl,

Message No. 6455 from the prozactruth support group reads:

Dear Maura,You said:I'm damn sure buspar needs certain enzymes that effexor was blockingto be broken down not 100% but We will have to look that up as a goodconsultant on his case can prove the high amounts of buspar in his systemwas caused by improper drug management. I became suicidal not homicidal.But it is all from to much serotonin. I to had no package insert. He needs apharmacological expert.>>CYP450 2D6, 1A2, 2C9, 3A4, and in part, 2C19 all play significantroles in inactivating Effexor (venlafaxine).Recently elucidated - Buspar (bupropion) is metabolized by CYP2B6,not 2D6, as once thought. It is now suspected to be a weak inhibitor ofCYP2D6.Perhaps this is a start for you. Forgive me if you already havethis information.Regards,

Is this what you were looking for? The Avenging Angel

Please sign the petitions at:

http://www.petitiononline.com/lilpro

http://www.petitiononline.com/oky71.html

http://www.petitiononline.com/effexor

----Original Message Follows---- From: "Cheryl Graves"

Reply-SSRI medications SSRI medications Subject: Re: Can you help me find a study??? Date: Mon, 18 Mar 2002 17:28:34 -0500

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Hi ...I'm very sorry, but I cannot find that study. I would

appreciate it so much if you can send it to me again. I need to forward it

to Steve's attorney. I will keep it forever in a special folder this time, I

promise. My brains are so scattered right now it's unreal. I'm surprised I

can even find my shoes! LOL... Thank you again my friend.

Love...Cheryl

>From: " Creel " <ccreel@...>

>Reply-SSRI medications

><SSRI medications >

>Subject: Re: Can you help me find a study???

>Date: Mon, 18 Mar 2002 11:37:49 -0500

>

>Dear Cheryl,

>

>

> You said:

>

><< Hi all. I need to find the study that I believe Maura(???) mentioned

>to

>me on the effects Buspar has on the bodies ability to metabolize Effexor.

>She had said that it blocks the enzymes necessary to metabolize effexor. I

>need to know if anyone can help me find the scientific study or SOME kind

>of

>proof of this.>>

>

>

> Check your email from Feb. 25 onward. I sent you this info a while ago.

>I'll put it together again if I have to do so; it would save me some time

>if

>you could find it. I don't know whether I sent it to you privately or on

>the

>list.

>

>Regards,

>

>

_________________________________________________________________

Send and receive Hotmail on your mobile device: http://mobile.msn.com

[Guest guest]

Cheryl,

Message No. 6455 from the prozactruth support group reads:

Dear Maura,You said:I'm damn sure buspar needs certain enzymes that effexor was blockingto be broken down not 100% but We will have to look that up as a goodconsultant on his case can prove the high amounts of buspar in his systemwas caused by improper drug management. I became suicidal not homicidal.But it is all from to much serotonin. I to had no package insert. He needs apharmacological expert.>>CYP450 2D6, 1A2, 2C9, 3A4, and in part, 2C19 all play significantroles in inactivating Effexor (venlafaxine).Recently elucidated - Buspar (bupropion) is metabolized by CYP2B6,not 2D6, as once thought. It is now suspected to be a weak inhibitor ofCYP2D6.Perhaps this is a start for you. Forgive me if you already havethis information.Regards,

Is this what you were looking for? The Avenging Angel

Please sign the petitions at:

http://www.petitiononline.com/lilpro

http://www.petitiononline.com/oky71.html

http://www.petitiononline.com/effexor

----Original Message Follows---- From: "Cheryl Graves"

Reply-SSRI medications SSRI medications Subject: Re: Can you help me find a study??? Date: Mon, 18 Mar 2002 17:28:34 -0500

Join the world’s largest e-mail service with MSN Hotmail. Click Here

Hi ...I'm very sorry, but I cannot find that study. I would

appreciate it so much if you can send it to me again. I need to forward it

to Steve's attorney. I will keep it forever in a special folder this time, I

promise. My brains are so scattered right now it's unreal. I'm surprised I

can even find my shoes! LOL... Thank you again my friend.

Love...Cheryl

>From: " Creel " <ccreel@...>

>Reply-SSRI medications

><SSRI medications >

>Subject: Re: Can you help me find a study???

>Date: Mon, 18 Mar 2002 11:37:49 -0500

>

>Dear Cheryl,

>

>

> You said:

>

><< Hi all. I need to find the study that I believe Maura(???) mentioned

>to

>me on the effects Buspar has on the bodies ability to metabolize Effexor.

>She had said that it blocks the enzymes necessary to metabolize effexor. I

>need to know if anyone can help me find the scientific study or SOME kind

>of

>proof of this.>>

>

>

> Check your email from Feb. 25 onward. I sent you this info a while ago.

>I'll put it together again if I have to do so; it would save me some time

>if

>you could find it. I don't know whether I sent it to you privately or on

>the

>list.

>

>Regards,

>

>

_________________________________________________________________

Send and receive Hotmail on your mobile device: http://mobile.msn.com

[Guest guest]

Hi. I'm not sure..I think so, but I need some sort of copy of the study

itself. Seems the courts won't allow anything else. Not our knowledge. They

will call it hearsay if it isn't an actual complete study. I'm

confused..But, yes, that does sound like what I need. I just need the whole

thing, as well as who did the study. Love............Cheryl

>From: " DAWN RIDER " <israelswarrior@...>

>Reply-SSRI medications

>SSRI medications

>Subject: Re: Can you help me find a study???

>Date: Tue, 19 Mar 2002 01:49:57 -0700

>

><< message3.txt >>

_________________________________________________________________

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Cheryl,

Message No. 6455 from the prozactruth support group reads:

Dear Maura,You said:I'm damn sure buspar needs certain enzymes that effexor was blockingto be broken down not 100% but We will have to look that up as a goodconsultant on his case can prove the high amounts of buspar in his systemwas caused by improper drug management. I became suicidal not homicidal.But it is all from to much serotonin. I to had no package insert. He needs apharmacological expert.>>CYP450 2D6, 1A2, 2C9, 3A4, and in part, 2C19 all play significantroles in inactivating Effexor (venlafaxine).Recently elucidated - Buspar (bupropion) is metabolized by CYP2B6,not 2D6, as once thought. It is now suspected to be a weak inhibitor ofCYP2D6.Perhaps this is a start for you. Forgive me if you already havethis information.Regards,

Is this what you were looking for? The Avenging Angel

Please sign the petitions at:

http://www.petitiononline.com/lilpro

http://www.petitiononline.com/oky71.html

http://www.petitiononline.com/effexor

----Original Message Follows----

From: "Cheryl Graves"

Reply-SSRI medications

SSRI medications

Subject: Re: Can you help me find a study???

Date: Mon, 18 Mar 2002 17:28:34 -0500

Join the world’s largest e-mail service with MSN Hotmail. Click Here

[Guest guest]

Dear Dawn,

You've done it again! Thank you so much for finding this!

I said:

<<CYP450 2D6, 1A2, 2C9, 3A4, and in part, 2C19 all play significant

roles in inactivating Effexor (venlafaxine).

Recently elucidated - Buspar (bupropion) is metabolized by CYP2B6,

not 2D6, as once thought. It is now suspected to be a weak inhibitor of

CYP2D6.>>

So what we have here is the possibility that Buspar was inhibiting the

2D6 substrate, causing a toxic build up of Effexor.

It also came to my attention recently that Buspar is also being suspected

of inhibiting 1A2. This also is needed to properly metabolize Effexor.

Overall, the real problem with these drugs, in a nutshell, is we really

don't know how they work. Electrophysiological studies support the

concept that Buspar's actions are through enhancement of noradrenergic and

dopamine pathways but we cannot be sure this is via re-uptake inhibition.

It's all a mystery.

This knowledge about CP450 and its isozymes is very new to science.

It takes ten years or more for anything new to become accepted as

fact. Because of this you cannot present this information as fact. But

what I see as a distinct possibility is using it to create enough doubt

about

the drugs so as to throw a monkey wrench in the guilt beyond resonable

doubt that must be proven.

What I would do (understand I am not an attorney) is collect everything

I could from the past three years that supports the premise that we don't

know how these drugs work (begin with the descriptions in the PDR).

I would then find an expert witness who will confirm this and add to it.

This will have to be drilled into the heads of people who have come to

trust and believe medicine. Most people, hell most physicians, do not know

what we here know. People find it almost impossible to fathom the FDA

approving these mystery drugs--I know I still do.

I hope this provides something useful for you, Cheryl.

Regards,

[Guest guest]

Dear Dawn,

You've done it again! Thank you so much for finding this!

I said:

<<CYP450 2D6, 1A2, 2C9, 3A4, and in part, 2C19 all play significant

roles in inactivating Effexor (venlafaxine).

Recently elucidated - Buspar (bupropion) is metabolized by CYP2B6,

not 2D6, as once thought. It is now suspected to be a weak inhibitor of

CYP2D6.>>

So what we have here is the possibility that Buspar was inhibiting the

2D6 substrate, causing a toxic build up of Effexor.

It also came to my attention recently that Buspar is also being suspected

of inhibiting 1A2. This also is needed to properly metabolize Effexor.

Overall, the real problem with these drugs, in a nutshell, is we really

don't know how they work. Electrophysiological studies support the

concept that Buspar's actions are through enhancement of noradrenergic and

dopamine pathways but we cannot be sure this is via re-uptake inhibition.

It's all a mystery.

This knowledge about CP450 and its isozymes is very new to science.

It takes ten years or more for anything new to become accepted as

fact. Because of this you cannot present this information as fact. But

what I see as a distinct possibility is using it to create enough doubt

about

the drugs so as to throw a monkey wrench in the guilt beyond resonable

doubt that must be proven.

What I would do (understand I am not an attorney) is collect everything

I could from the past three years that supports the premise that we don't

know how these drugs work (begin with the descriptions in the PDR).

I would then find an expert witness who will confirm this and add to it.

This will have to be drilled into the heads of people who have come to

trust and believe medicine. Most people, hell most physicians, do not know

what we here know. People find it almost impossible to fathom the FDA

approving these mystery drugs--I know I still do.

I hope this provides something useful for you, Cheryl.

Regards,

[Guest guest]

Thank you both so much. I will fwd this to his attorney.

Love.........Cheryl

>From: " Creel " <ccreel@...>

>Reply-SSRI medications

><SSRI medications >

>Subject: Re: Can you help me find a study???

>Date: Tue, 19 Mar 2002 11:15:43 -0500

>

>Dear Dawn,

>

>

> You've done it again! Thank you so much for finding this!

>

>I said:

>

><<CYP450 2D6, 1A2, 2C9, 3A4, and in part, 2C19 all play significant

>roles in inactivating Effexor (venlafaxine).

>

>Recently elucidated - Buspar (bupropion) is metabolized by CYP2B6,

>not 2D6, as once thought. It is now suspected to be a weak inhibitor of

>CYP2D6.>>

>

>

> So what we have here is the possibility that Buspar was inhibiting the

>2D6 substrate, causing a toxic build up of Effexor.

>

> It also came to my attention recently that Buspar is also being

>suspected

>of inhibiting 1A2. This also is needed to properly metabolize Effexor.

>

> Overall, the real problem with these drugs, in a nutshell, is we really

>don't know how they work. Electrophysiological studies support the

>concept that Buspar's actions are through enhancement of noradrenergic and

>dopamine pathways but we cannot be sure this is via re-uptake inhibition.

>It's all a mystery.

>

> This knowledge about CP450 and its isozymes is very new to science.

>It takes ten years or more for anything new to become accepted as

>fact. Because of this you cannot present this information as fact. But

>what I see as a distinct possibility is using it to create enough doubt

>about

>the drugs so as to throw a monkey wrench in the guilt beyond resonable

>doubt that must be proven.

>

> What I would do (understand I am not an attorney) is collect everything

>I could from the past three years that supports the premise that we don't

>know how these drugs work (begin with the descriptions in the PDR).

>I would then find an expert witness who will confirm this and add to it.

>This will have to be drilled into the heads of people who have come to

>trust and believe medicine. Most people, hell most physicians, do not know

>what we here know. People find it almost impossible to fathom the FDA

>approving these mystery drugs--I know I still do.

>

> I hope this provides something useful for you, Cheryl.

>

>Regards,

>

>

>

>

_________________________________________________________________

Join the world’s largest e-mail service with MSN Hotmail.

http://www.hotmail.com

[Guest guest]

Thank you both so much. I will fwd this to his attorney.

Love.........Cheryl

>From: " Creel " <ccreel@...>

>Reply-SSRI medications

><SSRI medications >

>Subject: Re: Can you help me find a study???

>Date: Tue, 19 Mar 2002 11:15:43 -0500

>

>Dear Dawn,

>

>

> You've done it again! Thank you so much for finding this!

>

>I said:

>

><<CYP450 2D6, 1A2, 2C9, 3A4, and in part, 2C19 all play significant

>roles in inactivating Effexor (venlafaxine).

>

>Recently elucidated - Buspar (bupropion) is metabolized by CYP2B6,

>not 2D6, as once thought. It is now suspected to be a weak inhibitor of

>CYP2D6.>>

>

>

> So what we have here is the possibility that Buspar was inhibiting the

>2D6 substrate, causing a toxic build up of Effexor.

>

> It also came to my attention recently that Buspar is also being

>suspected

>of inhibiting 1A2. This also is needed to properly metabolize Effexor.

>

> Overall, the real problem with these drugs, in a nutshell, is we really

>don't know how they work. Electrophysiological studies support the

>concept that Buspar's actions are through enhancement of noradrenergic and

>dopamine pathways but we cannot be sure this is via re-uptake inhibition.

>It's all a mystery.

>

> This knowledge about CP450 and its isozymes is very new to science.

>It takes ten years or more for anything new to become accepted as

>fact. Because of this you cannot present this information as fact. But

>what I see as a distinct possibility is using it to create enough doubt

>about

>the drugs so as to throw a monkey wrench in the guilt beyond resonable

>doubt that must be proven.

>

> What I would do (understand I am not an attorney) is collect everything

>I could from the past three years that supports the premise that we don't

>know how these drugs work (begin with the descriptions in the PDR).

>I would then find an expert witness who will confirm this and add to it.

>This will have to be drilled into the heads of people who have come to

>trust and believe medicine. Most people, hell most physicians, do not know

>what we here know. People find it almost impossible to fathom the FDA

>approving these mystery drugs--I know I still do.

>

> I hope this provides something useful for you, Cheryl.

>

>Regards,

>

>

>

>

_________________________________________________________________

Join the world’s largest e-mail service with MSN Hotmail.

http://www.hotmail.com