RE: searching - article about presence of antibodies and immunity

[Guest guest]

,

Is this the article you're looking for?

(http://www.nytimes.com/2004/01/22/nyregion/22CHAS.html)

or

(http://tinyurl.com/723ycn)

January 22, 2004

Merrill W. Chase Is Dead at 98; Scientist Who Advanced Immunology

By ANAHAD O'CONNOR

Dr. Merrill W. Chase, an immunologist whose

research on white blood cells helped undermine

the longstanding belief that antibodies alone

protected the body from disease and

micro-organisms, died on Jan. 5 at his home in

New York City, according to the Rockefeller

University, where he worked for 70 years. He was 98.

Dr. Chase made his landmark discovery in the

early 1940's while working with Dr. Karl

Landsteiner, a Nobel laureate recognized for his

work identifying the human blood groups. At the

time, experts believed that the body mounted its

attacks against pathogens primarily through

antibodies circulating in the blood stream, known as humoral immunity.

But Dr. Chase, working in his laboratory,

stumbled upon something that appeared to shatter that widespread tenet.

As he tried to immunize a guinea pig against a

disease using antibodies he had extracted from a

second pig, he found that blood serum did not work as the transfer agent.

Not until he used white blood cells did the

immunity carry over to the oher guinea pig,

providing solid evidence that it could not be

antibodies alone orchestrating the body's immune response.

Dr. Chase had uncovered the second arm of the

immune system, or cell-mediated immunity. His

finding became the groundwork for later research

that pinpointed B cells, T cells and other types

of white blood cells as the body's central safeguards against infection.

" This was a major discovery because everyone now

thinks of the immune response in two parts, and

in many instances it's the cellular components

that are more important, " said Dr. Michel

Nussenzweig, a professor of immunology at

Rockefeller. " Before Chase, there was only

humoral immunity. After him, there was humoral and cellular immunity. "

Dr. Chase's breakthrough generated little

interest at the time, but it set in motion the

research that helped redefine the fundamental nature of the immune system.

" So many areas of medicine rely on this type of

reaction that he clearly distinguished as not

being antibody mediated, " said Dr. Ralph

Steinman, a professor of cellular physiology and

immunology at Rockefeller. " People never

anticipated that there would be something other

than antibodies. It was an amazing finding. "

Born in Providence, R.I., in 1905, Merrill

Wallace Chase earned his bachelor's degree and

doctorate from Brown. He taught biology there for

a year, before joining the faculty at Rockefeller

in 1932 as an assistant to Dr. Landsteiner. He

has published at least 150 scientific papers.

On Thu, Jan 8, 2009 at 10:34 AM, cg_lem <cathy@...> wrote:

> Can someone help me find this? Recently-- and I thought it was on

> this list-- an article was shared about how a physician said he knew

> of no correlation between the presence of antibodies and immunity,

> that antibodies only meant EXPOSURE, not immunity to a disease.

>

> Can anyone help me find this again?

>

> THANKS!!

>

> - Lemmon

>

>

[Guest guest]

,

Is this the article you're looking for?

(http://www.nytimes.com/2004/01/22/nyregion/22CHAS.html)

or

(http://tinyurl.com/723ycn)

January 22, 2004

Merrill W. Chase Is Dead at 98; Scientist Who Advanced Immunology

By ANAHAD O'CONNOR

Dr. Merrill W. Chase, an immunologist whose

research on white blood cells helped undermine

the longstanding belief that antibodies alone

protected the body from disease and

micro-organisms, died on Jan. 5 at his home in

New York City, according to the Rockefeller

University, where he worked for 70 years. He was 98.

Dr. Chase made his landmark discovery in the

early 1940's while working with Dr. Karl

Landsteiner, a Nobel laureate recognized for his

work identifying the human blood groups. At the

time, experts believed that the body mounted its

attacks against pathogens primarily through

antibodies circulating in the blood stream, known as humoral immunity.

But Dr. Chase, working in his laboratory,

stumbled upon something that appeared to shatter that widespread tenet.

As he tried to immunize a guinea pig against a

disease using antibodies he had extracted from a

second pig, he found that blood serum did not work as the transfer agent.

Not until he used white blood cells did the

immunity carry over to the oher guinea pig,

providing solid evidence that it could not be

antibodies alone orchestrating the body's immune response.

Dr. Chase had uncovered the second arm of the

immune system, or cell-mediated immunity. His

finding became the groundwork for later research

that pinpointed B cells, T cells and other types

of white blood cells as the body's central safeguards against infection.

" This was a major discovery because everyone now

thinks of the immune response in two parts, and

in many instances it's the cellular components

that are more important, " said Dr. Michel

Nussenzweig, a professor of immunology at

Rockefeller. " Before Chase, there was only

humoral immunity. After him, there was humoral and cellular immunity. "

Dr. Chase's breakthrough generated little

interest at the time, but it set in motion the

research that helped redefine the fundamental nature of the immune system.

" So many areas of medicine rely on this type of

reaction that he clearly distinguished as not

being antibody mediated, " said Dr. Ralph

Steinman, a professor of cellular physiology and

immunology at Rockefeller. " People never

anticipated that there would be something other

than antibodies. It was an amazing finding. "

Born in Providence, R.I., in 1905, Merrill

Wallace Chase earned his bachelor's degree and

doctorate from Brown. He taught biology there for

a year, before joining the faculty at Rockefeller

in 1932 as an assistant to Dr. Landsteiner. He

has published at least 150 scientific papers.

On Thu, Jan 8, 2009 at 10:34 AM, cg_lem <cathy@...> wrote:

> Can someone help me find this? Recently-- and I thought it was on

> this list-- an article was shared about how a physician said he knew

> of no correlation between the presence of antibodies and immunity,

> that antibodies only meant EXPOSURE, not immunity to a disease.

>

> Can anyone help me find this again?

>

> THANKS!!

>

> - Lemmon

>

>

[Guest guest]

,

Is this the article you're looking for?

(http://www.nytimes.com/2004/01/22/nyregion/22CHAS.html)

or

(http://tinyurl.com/723ycn)

January 22, 2004

Merrill W. Chase Is Dead at 98; Scientist Who Advanced Immunology

By ANAHAD O'CONNOR

Dr. Merrill W. Chase, an immunologist whose

research on white blood cells helped undermine

the longstanding belief that antibodies alone

protected the body from disease and

micro-organisms, died on Jan. 5 at his home in

New York City, according to the Rockefeller

University, where he worked for 70 years. He was 98.

Dr. Chase made his landmark discovery in the

early 1940's while working with Dr. Karl

Landsteiner, a Nobel laureate recognized for his

work identifying the human blood groups. At the

time, experts believed that the body mounted its

attacks against pathogens primarily through

antibodies circulating in the blood stream, known as humoral immunity.

But Dr. Chase, working in his laboratory,

stumbled upon something that appeared to shatter that widespread tenet.

As he tried to immunize a guinea pig against a

disease using antibodies he had extracted from a

second pig, he found that blood serum did not work as the transfer agent.

Not until he used white blood cells did the

immunity carry over to the oher guinea pig,

providing solid evidence that it could not be

antibodies alone orchestrating the body's immune response.

Dr. Chase had uncovered the second arm of the

immune system, or cell-mediated immunity. His

finding became the groundwork for later research

that pinpointed B cells, T cells and other types

of white blood cells as the body's central safeguards against infection.

" This was a major discovery because everyone now

thinks of the immune response in two parts, and

in many instances it's the cellular components

that are more important, " said Dr. Michel

Nussenzweig, a professor of immunology at

Rockefeller. " Before Chase, there was only

humoral immunity. After him, there was humoral and cellular immunity. "

Dr. Chase's breakthrough generated little

interest at the time, but it set in motion the

research that helped redefine the fundamental nature of the immune system.

" So many areas of medicine rely on this type of

reaction that he clearly distinguished as not

being antibody mediated, " said Dr. Ralph

Steinman, a professor of cellular physiology and

immunology at Rockefeller. " People never

anticipated that there would be something other

than antibodies. It was an amazing finding. "

Born in Providence, R.I., in 1905, Merrill

Wallace Chase earned his bachelor's degree and

doctorate from Brown. He taught biology there for

a year, before joining the faculty at Rockefeller

in 1932 as an assistant to Dr. Landsteiner. He

has published at least 150 scientific papers.

On Thu, Jan 8, 2009 at 10:34 AM, cg_lem <cathy@...> wrote:

> Can someone help me find this? Recently-- and I thought it was on

> this list-- an article was shared about how a physician said he knew

> of no correlation between the presence of antibodies and immunity,

> that antibodies only meant EXPOSURE, not immunity to a disease.

>

> Can anyone help me find this again?

>

> THANKS!!

>

> - Lemmon

>

>

[Guest guest]

,

Is this the article you're looking for?

(http://www.nytimes.com/2004/01/22/nyregion/22CHAS.html)

or

(http://tinyurl.com/723ycn)

January 22, 2004

Merrill W. Chase Is Dead at 98; Scientist Who Advanced Immunology

By ANAHAD O'CONNOR

Dr. Merrill W. Chase, an immunologist whose

research on white blood cells helped undermine

the longstanding belief that antibodies alone

protected the body from disease and

micro-organisms, died on Jan. 5 at his home in

New York City, according to the Rockefeller

University, where he worked for 70 years. He was 98.

Dr. Chase made his landmark discovery in the

early 1940's while working with Dr. Karl

Landsteiner, a Nobel laureate recognized for his

work identifying the human blood groups. At the

time, experts believed that the body mounted its

attacks against pathogens primarily through

antibodies circulating in the blood stream, known as humoral immunity.

But Dr. Chase, working in his laboratory,

stumbled upon something that appeared to shatter that widespread tenet.

As he tried to immunize a guinea pig against a

disease using antibodies he had extracted from a

second pig, he found that blood serum did not work as the transfer agent.

Not until he used white blood cells did the

immunity carry over to the oher guinea pig,

providing solid evidence that it could not be

antibodies alone orchestrating the body's immune response.

Dr. Chase had uncovered the second arm of the

immune system, or cell-mediated immunity. His

finding became the groundwork for later research

that pinpointed B cells, T cells and other types

of white blood cells as the body's central safeguards against infection.

" This was a major discovery because everyone now

thinks of the immune response in two parts, and

in many instances it's the cellular components

that are more important, " said Dr. Michel

Nussenzweig, a professor of immunology at

Rockefeller. " Before Chase, there was only

humoral immunity. After him, there was humoral and cellular immunity. "

Dr. Chase's breakthrough generated little

interest at the time, but it set in motion the

research that helped redefine the fundamental nature of the immune system.

" So many areas of medicine rely on this type of

reaction that he clearly distinguished as not

being antibody mediated, " said Dr. Ralph

Steinman, a professor of cellular physiology and

immunology at Rockefeller. " People never

anticipated that there would be something other

than antibodies. It was an amazing finding. "

Born in Providence, R.I., in 1905, Merrill

Wallace Chase earned his bachelor's degree and

doctorate from Brown. He taught biology there for

a year, before joining the faculty at Rockefeller

in 1932 as an assistant to Dr. Landsteiner. He

has published at least 150 scientific papers.

On Thu, Jan 8, 2009 at 10:34 AM, cg_lem <cathy@...> wrote:

> Can someone help me find this? Recently-- and I thought it was on

> this list-- an article was shared about how a physician said he knew

> of no correlation between the presence of antibodies and immunity,

> that antibodies only meant EXPOSURE, not immunity to a disease.

>

> Can anyone help me find this again?

>

> THANKS!!

>

> - Lemmon

>

>

[Guest guest]

Yes, I believe this is the one I saw. Thanks, !

- Lemmon

> > Can someone help me find this? Recently-- and I thought it was on

> > this list-- an article was shared about how a physician said he knew

> > of no correlation between the presence of antibodies and immunity,

> > that antibodies only meant EXPOSURE, not immunity to a disease.

> >

> > Can anyone help me find this again?

> >

> > THANKS!!

> >

> > - Lemmon

> >

> >

>

[Guest guest]

Yes, I believe this is the one I saw. Thanks, !

- Lemmon

> > Can someone help me find this? Recently-- and I thought it was on

> > this list-- an article was shared about how a physician said he knew

> > of no correlation between the presence of antibodies and immunity,

> > that antibodies only meant EXPOSURE, not immunity to a disease.

> >

> > Can anyone help me find this again?

> >

> > THANKS!!

> >

> > - Lemmon

> >

> >

>

[Guest guest]

It was at one time on minutus and/or vaccinations forums....I was

asking for it a while ago - I could dig around

Liz

>

> Can someone help me find this? Recently-- and I thought it was on

> this list-- an article was shared about how a physician said he knew

> of no correlation between the presence of antibodies and immunity,

> that antibodies only meant EXPOSURE, not immunity to a disease.

>

> Can anyone help me find this again?

>

> THANKS!!

>

> - Lemmon

>

[Guest guest]

It was at one time on minutus and/or vaccinations forums....I was

asking for it a while ago - I could dig around

Liz

>

> Can someone help me find this? Recently-- and I thought it was on

> this list-- an article was shared about how a physician said he knew

> of no correlation between the presence of antibodies and immunity,

> that antibodies only meant EXPOSURE, not immunity to a disease.

>

> Can anyone help me find this again?

>

> THANKS!!

>

> - Lemmon

>

[Guest guest]

Funny you should mention this possibly being on the Minutus list, Liz. I'm also on that list-- maybe that is where I first saw this article, not here.

Maybe it was that I saw you there asking for it. . . . . . .

The article shared is great-- I've saved that one. But please let me know if you can find what may have been shared on Minutus. (I'll look in my notes from there as well.)

Thanks!

- Lemmon

---------------------------------------------------------------------------------------------------------------------------------------

Re: searching - article about presence of antibodies and immunity Posted by: " Brandegee" Fri Jan 9, 2009 9:44 am (PST)

It was at one time on minutus and/or vaccinations forums....I was asking for it a while ago - I could dig around :)Liz

[Guest guest]

Yes, it was that whole 'titers' thread - I'll look, I've been meaning

to compile all that Yes, a, Fran and Sheri had some good info

I think.

Liz

>

>

> Funny you should mention this possibly being on the Minutus list, Liz.

> I'm also on that list-- maybe that is where I first saw this article,

> not here.

>

>

> Maybe it was that I saw you there asking for it. . . . . . .

>

>

> The article shared is great-- I've saved that one. But please let

> me know if you can find what may have been shared on Minutus. (I'll

> look in my notes from there as well.)

>

>

> Thanks!

>

>

> - Lemmon

>

>

> ------------------------------------------------------------------------

> ---------------------------------------------------------------

>

>

> Re: searching - article about presence of antibodies and immunity

> <no-forced-vaccination/message/7122;_ylc=X

> 3oDMTJyMG91bG8zBF9TAzk3MzU5NzE1BGdycElkAzIxMzk2MzcwBGdycHNwSWQDMTcwNTA2N

> DMwOQRtc2dJZAM3MTIyBHNlYwNkbXNnBHNsawN2bXNnBHN0aW1lAzEyMzE1OTg3NjI->

> Posted by: " Brandegee "

> Fri Jan 9, 2009 9:44 am (PST)

>

> It was at one time on minutus and/or vaccinations forums....I was

> asking for it a while ago - I could dig around

>

> Liz

>

[Guest guest]

Yes, it was that whole 'titers' thread - I'll look, I've been meaning

to compile all that Yes, a, Fran and Sheri had some good info

I think.

Liz

>

>

> Funny you should mention this possibly being on the Minutus list, Liz.

> I'm also on that list-- maybe that is where I first saw this article,

> not here.

>

>

> Maybe it was that I saw you there asking for it. . . . . . .

>

>

> The article shared is great-- I've saved that one. But please let

> me know if you can find what may have been shared on Minutus. (I'll

> look in my notes from there as well.)

>

>

> Thanks!

>

>

> - Lemmon

>

>

> ------------------------------------------------------------------------

> ---------------------------------------------------------------

>

>

> Re: searching - article about presence of antibodies and immunity

> <no-forced-vaccination/message/7122;_ylc=X

> 3oDMTJyMG91bG8zBF9TAzk3MzU5NzE1BGdycElkAzIxMzk2MzcwBGdycHNwSWQDMTcwNTA2N

> DMwOQRtc2dJZAM3MTIyBHNlYwNkbXNnBHNsawN2bXNnBHN0aW1lAzEyMzE1OTg3NjI->

> Posted by: " Brandegee "

> Fri Jan 9, 2009 9:44 am (PST)

>

> It was at one time on minutus and/or vaccinations forums....I was

> asking for it a while ago - I could dig around

>

> Liz

>