Guest guest Posted August 25, 2001 Report Share Posted August 25, 2001 FYI - We all need to be concerned about liver toxicity! MM / NSIF ----- Original Message ----- From: ParfumGigi@... MAM-NSIF@... ; IceMaidenZ@... ; lillian45usa2000@... Cc: SBIPrayerForum Sent: Friday, August 24, 2001 11:41 PM Subject: Polyvinyl Chloride I'll send more on this toxic chemical in implants Gastrointestinal or Liver Toxicity Definitions Gastrointestinal and liver toxicity is defined as adverse effects on the structure and/or functioning of the gastrointestinal tract, liver, or gall bladder that result from exposure to chemical substances. The liver functions as a center for metabolism, processing chemicals we are exposed to so they can be utilized, detoxified, or excreted. While chemicals absorbed from the gastrointestinal tract are always processed by the liver, toxicants that enter the body through other routes of exposure can also reach the liver via its blood supply from the hepatic artery and the portal vein. The liver is frequently subject to injury induced by chemicals, called hepatotoxins, because of its role as the body's principal site of metabolism. Necrosis, or liver cell death, is a common effect of acute exposure to hepatotoxic chemicals like beryllium, phosphorus, and urethane. The necrosis can be localized in specific areas of the liver or be more widespread. The liver is usually able to recover from necrosis because of its remarkable regenerative capacity. Exposure to hepatotoxic substances can also cause fatty liver (steatosis), hepatitis, jaundice, cholestasis, chronic liver damage (cirrhosis), and cancer. Carbon tetrachloride and related chemicals, such as chloroform, are linked to steatosis, necrosis, and cirrhosis of the liver. The most frequent cause of cirrhosis, however, is the habitual consumption of large quantities of alcohol. Cancer of the liver has been associated with occupational exposures to arsenic, copper, and vinyl chloride. The gastrointestinal, or digestive, tract is composed of the esophagus, stomach, pancreas, and small and large intestines. The gastrointestinal tract is the site of entry for chemicals that are ingested. Exposure to chemicals that are toxic to the digestive tract can cause anorexia, nausea, vomiting, abdominal cramps, and diarrhea. There are four major types of tissue response to gastrointestinal injury from toxic agents: ulceration, necrosis, inflammation, and proliferation, including cancer. Some chemicals that cause gastrointestinal injury are halogenated aromatic hydrocarbons, including chlorobenzene and hexachlorobenzene, and such metals as lead, mercury, arsenic, and cadmium. Nitrosamines have been shown to cause colon cancer in humans. For further general information on chemicals and gastrointestinal and liver toxicity, see the following references: Britton, R. S. Metal-Induced Hepatotoxicity. Seminars in Liver Disease. 16(1): 3-12. 1996. Plaa, G. Toxic Responses of the Liver. Chapter 10 in Casarett and Doull's Toxicology, edited by C. Klaassen, M. Amdur, and J. Doull. New York: Pergamon Press, 1996. Rozman, K., ed. Gastrointestinal Toxicology. New York: Elsevier, 1986. All my love on the Wings of a White Dove ~ Together we can conquer anything, and learn to fly higher than ever before* Peace, truth, and research now, gigi President NSIF National Silicone Implant Foundation Director, Martha Murdock Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 25, 2001 Report Share Posted August 25, 2001 FYI -- More Liver & Gastrointestinal Information for SBI Women's Concerns, MM / NSIF ----- Original Message ----- From: ParfumGigi@... MAM-NSIF@... ; IceMaidenZ@... ; lillian45usa2000@... Cc: SBIPrayerForum ; pat2end@... ; PEEPERLY@... ; RAve456201@... ; SWEETCAROLINELV@... ; nye822@... ; Gimfl@... ; wan6922@... ; SLIM2RB@... ; Sparkielane@... ; tennrose@... ; weedsworld@... ; NoMoreMcGhans@... ; REABEEE@... ; jndolson@... ; lorenn@... ; GATOR1KW@... ; Anane4@... ; blue_bell@... Sent: Friday, August 24, 2001 11:59 PM Subject: Polyvinyl Chloride I'll send more on this toxic chemical in implants Gastrointestinal or Liver Toxicity Definitions Gastrointestinal and liver toxicity is defined as adverse effects on the structure and/or functioning of the gastrointestinal tract, liver, or gall bladder that result from exposure to chemical substances. The liver functions as a center for metabolism, processing chemicals we are exposed to so they can be utilized, detoxified, or excreted. While chemicals absorbed from the gastrointestinal tract are always processed by the liver, toxicants that enter the body through other routes of exposure can also reach the liver via its blood supply from the hepatic artery and the portal vein. The liver is frequently subject to injury induced by chemicals, called hepatotoxins, because of its role as the body's principal site of metabolism. Necrosis, or liver cell death, is a common effect of acute exposure to hepatotoxic chemicals like beryllium, phosphorus, and urethane. The necrosis can be localized in specific areas of the liver or be more widespread. The liver is usually able to recover from necrosis because of its remarkable regenerative capacity. Exposure to hepatotoxic substances can also cause fatty liver (steatosis), hepatitis, jaundice, cholestasis, chronic liver damage (cirrhosis), and cancer. Carbon tetrachloride and related chemicals, such as chloroform, are linked to steatosis, necrosis, and cirrhosis of the liver. The most frequent cause of cirrhosis, however, is the habitual consumption of large quantities of alcohol. Cancer of the liver has been associated with occupational exposures to arsenic, copper, and vinyl chloride. The gastrointestinal, or digestive, tract is composed of the esophagus, stomach, pancreas, and small and large intestines. The gastrointestinal tract is the site of entry for chemicals that are ingested. Exposure to chemicals that are toxic to the digestive tract can cause anorexia, nausea, vomiting, abdominal cramps, and diarrhea. There are four major types of tissue response to gastrointestinal injury from toxic agents: ulceration, necrosis, inflammation, and proliferation, including cancer. Some chemicals that cause gastrointestinal injury are halogenated aromatic hydrocarbons, including chlorobenzene and hexachlorobenzene, and such metals as lead, mercury, arsenic, and cadmium. Nitrosamines have been shown to cause colon cancer in humans. For further general information on chemicals and gastrointestinal and liver toxicity, see the following references: Britton, R. S. Metal-Induced Hepatotoxicity. Seminars in Liver Disease. 16(1): 3-12. 1996. Plaa, G. Toxic Responses of the Liver. Chapter 10 in Casarett and Doull's Toxicology, edited by C. Klaassen, M. Amdur, and J. Doull. New York: Pergamon Press, 1996. Rozman, K., ed. Gastrointestinal Toxicology. New York: Elsevier, 1986. All my love on the Wings of a White Dove ~ Together we can conquer anything, and learn to fly higher than ever before* Peace, truth, and research now, gigi President NSIF National Silicone Implant Foundation Director, Martha Murdock Quote Link to comment Share on other sites More sharing options...
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