YMDD motif variants in inactive hepatitis B carriers detected by Inno-Lipa HBV D

November 6, 2006

YMDD motif variants in inactive hepatitis B carriers detected by Inno-Lipa

HBV DR assay

Authors: Akarsu, Mesut; Sengonul, Aylin1; Tankurt, Ethem2; Sayiner, Ayca

Arzu1; Topalak, Omer2; Akpinar, Hale2; Abacioglu, Yusuf Hakan1

Source: Journal of Gastroenterology and Hepatology, Volume 21, Number 12,

December 2006, pp. 1783-1788(6)

Abstract:

Introduction: & #8194;

Mutations of hepatitis B virus (HBV) polymerase, especially occurring at the

highly conserved YMDD region, are related to resistance to lamivudine.

Although these mutations are frequently secondary to lamivudine use, they

can also occur naturally. The aim of the present study was to determine the

prevalence of YMDD variants that exist naturally in patients who are

inactive HBV carriers. Methods: & #8194;

Seventy-one adult inactive HBV carriers were studied. All of the patients

were confirmed to have maintained normal alanine aminotransferase (ALT)

values for one or more years by monitoring serum ALT levels at 3-monthly

intervals. None of the patients received interferon or antiviral agents.

YMDD variants were analyzed by the HBV Drug Resistance Line Probe assay

(Inno-Lipa HBV-DR). Results: & #8194;

YMDD variants were detected in 13 (18.3%) of the 71 anti-HBe positive

inactive HBV carriers. Of the 13 patients, 10 (76.9%) also had accompanying

L180M mutation. The combination of wild type and YMDD variant HBV was

present in 11 of 13 patients. In two patients, only YIDD and/or YVDD

variants plus L180M were detected without the presence of wild YMDD motif.

Conclusion: & #8194;

Naturally occurring YMDD motif variants were detected at a high rate in a

group of lamivudine-untreated inactive HBV carriers.

Document Type: Research article

DOI: 10.1111/j.1440-1746.2006.04567.x

Affiliations: 1: Microbiology and Clinical Microbiology, Faculty of

Medicine, Dokuz Eylul University, Izmir, Turkey 2: Departments of

Gastroenterology and

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