Clinicopathological differences between hepatitis B viral genotype B- and C-rela

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Journal of Viral Hepatitis

Volume 14 Issue 1 Page 64 - January 2007

doi:10.1111/j.1365-2893.2006.00776.x

Volume 14 Issue 1

Clinicopathological differences between hepatitis B viral genotype B- and

C-related resectable hepatocellular carcinoma

C-L. Lin1, J-D. Chen2, C-J. Liu2, P-H. Lee3, P-J. Chen2,4, M-Y. Lai2,4, J-H.

Kao2,4,5 and D-S. Chen2

Summary. Clinical and pathogenic differences exist between hepatitis B viral

(HBV) genotypes B and C, and genotype C has a higher risk of hepatocellular

carcinoma (HCC) development than genotype B. The aim of this study was to

investigate whether HBV genotypes B and C influence the clinicopathological

features of patients with resectable HCC. Stored serum samples from 193

patients with resectable HBV-related HCC were tested for HBV genotypes by a

molecular method. Of 193 patients undergoing resection of HCC, 107 (55%) and

86 (45%) were infected with genotypes B and C, respectively. Compared with

genotype C patients, genotype B patients were less likely to be associated

with liver cirrhosis (33%vs 51%, P = 0.01). Pathologically, genotype B

patients had a higher rate of solitary tumour (94%vs 86%, P = 0.048) and

more satellite nodules (22%vs 12%, P = 0.05) than genotype C patients. Our

results indicate that genotype B-related HCC is less associated with liver

cirrhosis and has a higher frequency of solitary tumour as well as more

satellite nodules than genotype C-related HCC. These characteristics may

contribute to the recurrence patterns and prognosis of HBV-related HCC in

patients with genotype B or C infection.

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