Long-term antibody persistence and immune memory to hepatitis B virus in adult celiac patients vaccinated as adolescents.

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Vaccine. 2010 Nov 30. [Epub ahead of print]

Long-term antibody persistence and immune memory to hepatitis B virus in adult

celiac patients vaccinated as adolescents.

Zingone F, Morisco F, Zanetti A, Romanò L, Portella G, Capone P, Andreozzi P,

Tortora R, Ciacci C.

Department of Clinical and Experimental Medicine, " Federico II " University of

Naples, Italy.

Abstract

Aim of this study was to investigate the anti-HBs antibody persistence and

immune memory to hepatitis B virus in adult celiacs vaccinated as adolescents

and the effect of a booster administration in non-protected individuals. Eleven

years after primary vaccination, the proportion of vaccinees with titres

≥10mIU/ml and antibody geometric mean concentrations (GMCs) were lower among

celiac patients than among controls (68.6% vs 91.7%, p<0.01; GMCs 29.38mIU/ml vs

250.6mIU/ml, p<0.001). Participants with anti-HBs below 10mIU/ml received a

booster dose and were retested 2 weeks later to assess the anamnestic response.

Post-booster anti-HBs levels were still <10mIU/ml in 71.4% celiacs and 25%

controls (p<0.01). Our findings indicate that the prevalence of seroprotective

levels of anti-HBs detected eleven years after primary immunization as well as

the frequency of response to a booster dose of vaccine are lower in celiac

patients compared to healthy controls.

Copyright © 2010. Published by Elsevier Ltd.

PMID: 21129395 [PubMed - as supplied by publisher]