Increased Oxidative Stress, Decreased Total Antioxidant Capacity, and Iron Overload in Untreated Patients with Chronic Hepatitis C

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http://www.springerlink.com/content/mu333k750070163l/

Journal Digestive Diseases and Sciences

Publisher Springer Netherlands

ISSN 0163-2116 (Print) 1573-2568 (Online)

Category Original Article

DOI 10.1007/s10620-009-0833-1

Subject Collection Medicine

SpringerLink Date Wednesday, June 10, 2009

Original Article

Increased Oxidative Stress, Decreased Total Antioxidant Capacity, and Iron

Overload in Untreated Patients with Chronic Hepatitis C

le Venturini1, Andréa Name Colado Simão1, Décio Sabbatini Barbosa1, Edson

Lopes Lavado2, Victor Emanuel Soares Narciso3, Isaias Dichi3 and Jane Bandeira

Dichi3

(1) Department of Pathology, Clinical Analysis and Toxicology, University of

Londrina, Londrina, Paraná, Brazil

(2) Department of Physiotherapy, University of Londrina, Londrina, Paraná,

Brazil

(3) Department of Internal Medicine, University of Londrina, Avenida

Koch no. 60 Bairro Cervejaria, Londrina, Paraná, Brazil

Received: 7 October 2008 Accepted: 30 April 2009 Published online: 10 June

2009

Abstract

The aim of this study was to determine oxidative stress in patients with

untreated chronic hepatitis C (CHC), relating the obtained results with iron

status and disease activity markers. Two groups (CHC patients and controls) were

studied. CHC patients presented significantly higher values than the control

group in some parameters: ALT, AST, GGT, iron, ferritin, and transferrin

saturation, and also in tert-butyl hydroperoxide initiate chemiluminescence and

thiobarbituric acid-reactive substances (TBARS) as well as lower values in total

radical-trapping antioxidant parameter (TRAP). TBARS showed a significant

correlation with serum AST and with transferrin saturation, whereas TRAP

correlated inversely with serum albumin. Serum ferritin correlated with ALT and

GGT, whereas serum iron did so with GGT. In conclusion, lower antioxidant

capacity, higher levels of pro-oxidants activity, and iron overload occur in

untreated patients with CHC. This greater oxidative activity could play an

important role in pathogenesis and evolution of hepatitis C and thus further

investigations.

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Isaias Dichi

Email: dichi@...

Jane Bandeira Dichi (Corresponding author)

Email: dichi@...