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Urticaria and Hepatitis

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Urticaria and Hepatitis

Author: Cribier, Bernard

Source: Clinical Reviews in Allergy and Immunology, Volume 30, Number 1,

February 2006, pp. 25-30(6)

Publisher:Humana Press

Abstract:

Acute urticaria is commonly observed in the prodromic stage of hepatitis A

and B infection as well as in hepatitis C infection, although only rare

cases have been published regarding the latter. Urticaria is considered one

of the pre-icteric symptoms of viral hepatitis and is related to

immune-complex deposits; subsequently, it may be associated with arthritis

and headache (Caroli's triad). The absence of specific presentation of acute

urticaria in patients with viral hepatitis is not surprising because many

other viral infections can induce similar cutaneous symptoms. On the other

hand, no convincing evidence exists in which hepatitis virus infection

caused chronic urticaria. Data are lacking for hepatitis B, but several

series and one controlled study showed the absence of a link between

hepatitis C and chronic urticaria. Systematic hepatitis virus investigations

in patients with chronic urticaria probably are not cost-effective.

Hepatitis B or C can occasionally induce urticarial vasculitis, but this is

probably related more to vasculitis than to true urticaria.

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