Surveillance programme for hepatocellular carcinoma improves the survival of patients with chronic v

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Liver International 28 (1), 79–87.

doi:10.1111/j.1478-3231.2007.01576.x

Abstract

CLINICAL STUDIES

Surveillance programme for hepatocellular carcinoma improves the survival of

patients with chronic viral hepatitis

Grace Lai-Hung Wong11 Institute of Digestive Disease and Department of Medicine

and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China,

Wai-Sun Wong11 Institute of Digestive Disease and Department of Medicine

and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China,

Guang-Ming Tan11 Institute of Digestive Disease and Department of Medicine and

Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China, Ka-Ian

Ip11 Institute of Digestive Disease and Department of Medicine and Therapeutics,

The Chinese University of Hong Kong, Hong Kong SAR, China, Wing-Kwan Lai11

Institute of Digestive Disease and Department of Medicine and Therapeutics, The

Chinese University of Hong Kong, Hong Kong SAR, China, Yuk-Wah Li11 Institute of

Digestive Disease and Department of Medicine and Therapeutics, The Chinese

University of Hong Kong, Hong Kong SAR, China, Mercedes Shun-Chi Mak11 Institute

of Digestive Disease and Department of Medicine and Therapeutics, The Chinese

University of Hong Kong, Hong Kong SAR, China, Bo-San Lai22 Department of

Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China, ph

Jao-Yiu Sung11 Institute of Digestive Disease and Department of Medicine and

Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China and

Henry Lik-Yuen Chan11 Institute of Digestive Disease and Department of Medicine

and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China1

Institute of Digestive Disease and Department of Medicine and Therapeutics, The

Chinese University of Hong Kong, Hong Kong SAR, China

2 Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR,

China

Correspondence

Henry L. Y. Chan, MD, Institute of Digestive Disease and Department of Medicine

and Therapeutics, The Chinese University of Hong Kong, 9/F Prince of Wales

Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong SAR, China

Tel: +852 2632 3307

Fax: +852 2637 3852

e-mail: hlychan@...

Abstract

Background: The survival benefit of surveillance for hepatocellular carcinoma

(HCC) is controversial.

Aim: We aimed to examine the survival benefit of HCC surveillance in chronic

viral hepatitis.

Methods: Survivals of HCC patients related to chronic viral hepatitis from the

Hepatology Clinic (surveillance group) were compared with those referred from

other hospitals/clinics (no-surveillance group). Lead-time and length-time

biases were adjusted based on tumour volume doubling times.

Results: Among 579 patients (91% hepatitis , 472 (82%) patients had HCC and 79

(17%) of these patients were referred from the surveillance programme. HCC was

smaller (4.2 vs. 7.7 cm; P

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