Facial Cosmetic Filler Injections as Possible Target for Systemic Sarcoidosis in Patients Treated wi

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Case Report

Facial Cosmetic Filler Injections as Possible Target for Systemic Sarcoidosis in

Patients Treated with Interferon for Chronic Hepatitis C: Two Cases

Descampsa, Landrya, Camille Francèsd, Marinhob, Vlad

Ratziuc, Olivier Chosidowd

Departments of

aDermatology and

bHistopathology, Bichat Claude Bernard Hospital, and

cDepartment of Hepatology, Pitié Salpêtrière Hospital, AP-HP, Paris 7

University, and

dDepartment of Dermatology, Tenon Hospital, AP-HP, Paris 6 Pierre et Marie Curie

University, Paris, France

Address of Corresponding Author

Dermatology 2008;217:81-84 (DOI: 10.1159/000128281)

Abstract

Background: Cosmetic filler injections are now a very common procedure for

aesthetic purposes. Today no contra-indication is given anymore to any patient

for an intradermal filling. Objectives: We draw attention to a possible side

effect of facial fillers in a population at risk. Results: We report 2 similar

cases of systemic sarcoidosis in patients who both developed a sarcoidal

granuloma at the location of a cosmetic filler injection during combined

interferon and ribavirin treatment for chronic hepatitis C infection. Cosmetic

fillers were hyaluronic acid for one patient and probably silicone for the

other. Conclusion: Patients with chronic hepatitis C have a higher risk of

interferon-induced sarcoidosis. Physicians must be aware of the risk that a

granuloma can develop after a dermal filler injection especially in patients

treated with interferon for chronic hepatitis C. These reactions may reveal a

systemic sarcoidosis. We propose to perform a test for a hepatitis C virus

infection before injecting a dermal filler and to inform the patient of this

risk in case of a hepatitis C infection that could necessitate an interferon

treatment.

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