Interaction of alcohol intake and cofactors on the risk of cirrhosis

[Guest guest]

http://www.ingentaconnect.com/content/mksg/liv/2010/00000030/00000006/art00012

Interaction of alcohol intake and cofactors on the risk of cirrhosis

Authors: Stroffolini, Tommaso1; Cotticelli, Gaetano2; Medda, Emanuela3; Niosi,

Marco2; Del Vecchio-Blanco, Camillo2; Addolorato, Giovanni4; Petrelli, Enzo4;

Salerno, T.4; Picardi, 4; Bernardi, Mauro4; Almasio, Piero4;

Bellentani, Stefano4; Surace, Lorenzo A.4; Loguercio, Carmela2

Source: Liver International, Volume 30, Number 6, July 2010 , pp. 867-870(4)

Publisher: Blackwell Publishing

Abstract:

Objective:

Evaluation of the interaction between alcohol intake and cofactors [hepatitis B

virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on

the risk of cirrhosis. Design:

Seven hundred and forty-nine consecutive patients with chronic liver disease

referring to units for liver or alcohol diseases in Italy during a 6-months

period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were

evaluated using chronic hepatitis cases as the control group. Results:

An alcohol intake of more than 3 units/day resulted associated with the

likelihood of cirrhosis both in males (OR 4.3; 95% CI=2.5-7.3) and in females

(OR 5.7; 95% CI=2.3-14.5). A multiplicative interaction on the risk of cirrhosis

between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was

observed. A reduction of cirrhosis risk was observed in subjects consuming more

than 3 alcohol units/day with increasing coffee intake. The OR for the

association with cirrhosis decreased from 2.3 (95% CI=1.2-4.4) in subjects

drinking 0-2 cups of coffee/day to 1.4 (95% CI=0.6-3.6) in those drinking more

than 2 cups/day. Conclusions:

In subjects with an alcohol intake>3 units/day the coexistence of HBV or HCV

multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic

cirrhosis risk.

Keywords: alcohol; cirrhosis; coffee

Document Type: Research article

DOI: 10.1111/j.1478-3231.2010.02261.x

Affiliations: 1: Department of Infectious and Tropical Diseases, Policlinico

Umberto I, Rome, Italy 2: Division of Gastroenterology and Hepatology,

Department of Clinical and Experimental Internal Medicine `F. Magrassi & A.

Lanzara- Interuniversity Centre on Foods, Nutrition and Gastrointestinal Tract

(CIRANAD) Second University of Naples, Naples, Italy 3: National Institute of

Health, Rome, Italy 4: AISF-SIA National Group:Vonghia L (Rome), Volpe M

(Pesaro), Lomazzo D (Bari), D'Avola D (Rome), Caputo F (Bologna), Cottone C

(Palermo), Scaglioni F (Modena), Pontoriero L (Lamezia Terme)

_________________________________________________________________

The New Busy is not the old busy. Search, chat and e-mail from your inbox.

http://www.windowslive.com/campaign/thenewbusy?ocid=PID28326::T:WLMTAGL:ON:WL:en\

-US:WM_HMP:042010_3