Viral hepatitis and inflammatory bowel disease.

[Guest guest]

Inflamm Bowel Dis. 2010 Jun;16(6):925-32.

Viral hepatitis and inflammatory bowel disease.

Hou JK, Velayos F, Terrault N, Mahadevan U.

Baylor College of Medicine, Houston, Texas, USA.

Abstract

Viral hepatitis is common worldwide and in the United States. Inflammatory bowel

disease (IBD) patients with chronic hepatitis B virus (HBV) with active disease

(elevated alanine aminotransferase level and viral replication) should receive

HBV treatment. HBV reactivation is associated with significant morbidity and

mortality in patients receiving immunosuppression. IBD patients may require

long-term immunosuppression, and therefore should be considered candidates for

vaccination against new HBV infection as well as prophylaxis against HBV

reactivation prior to immunosuppressive therapy. Tumor necrosis factor alpha

antagonists and immunomodulators appear compatible with use in IBD patients with

HCV, although prednisone may increase viral replication. HCV treatment with

peg-interferon and ribavirin may exacerbate gastrointestinal symptoms, and

therefore the decision to treat HCV needs to be individualized. Management of

IBD patients with viral hepatitis is addressed in this review.

PMID: 20480515 [PubMed - in process]

_________________________________________________________________

The New Busy is not the too busy. Combine all your e-mail accounts with Hotmail.

http://www.windowslive.com/campaign/thenewbusy?tile=multiaccount & ocid=PID28326::\

T:WLMTAGL:ON:WL:en-US:WM_HMP:042010_4