Guest guest Posted March 22, 2004 Report Share Posted March 22, 2004 You know, we just had a situation here locally where a kid, on antidepressents, went off the deep end, hit his mother with a metal pipe on the head, then shot and killed a police office (who was expecting his first baby any day), then held police at bay for over 24 hours, during which time he shot and killed himself. Wouldn't surprise me at all to find out the drugs did it to him. Sherri Garrett 324/219/150 105 lost Obesityhelp HTML Volunteer AOL name: Lvnjason My personal profile page; http://www.obesityhelp.com/morbidobesity/profile phtml?N=G1026326366 -- FDA warning Nature http://www.usatoday com/money/industries/health/drugs/2004-03-22-antidepressants_x.htm Antidepressants may have opposite effect, FDA warns WASHINGTON (AP) — Patients on some popular antidepressants should be closely monitored for warning signs of suicide, the government warned Monday in asking the makers of 10 drugs to add the caution to their labels. Although the Food and Drug Administration's investigation into the possible suicide connection initially focused on children given the drugs, its warning is aimed at both adult and pediatric use. It isn't clear the drugs actually do lead to suicide, the FDA stressed. But until that is settled, advisers to the FDA called last month for stronger warnings to doctors and parents that the antidepressants may cause agitation anxiety and hostility in a subset of patients who may be unusually prone to rare side effects. On Monday, the FDA followed its advisers' recommendation and issued a public health advisory putting doctors, patients, families and other caregivers on notice to be particularly vigilant for signs of worsening depression or suicidal thoughts at the beginning of antidepressant therapy or whenever the dose is changed. The drugs of concern are all newer-generation antidepressants: Prozac, Paxil Zoloft, Effexor, Celexa, Remeron, Lexapro, Luvox, Serzone and Wellbutrin. Most are known to affect the brain chemical serotonin. British health authorities sounded the alarm last year, saying long-suppressed research suggests certain antidepressants might sometimes increase the risk of suicidal behavior in children and teenagers. Because only one drug, Prozac, has been proved to alleviate pediatric depression, Britain declared others — drugs called SSRIs and their close relatives — unsuitable for depressed youth. The FDA issued a caution on pediatric use last year, but Monday's action — especially the addition of the warning to drug labels — goes significantly further. Dozens of anguished parents pleaded with the FDA in a meeting last month to add such warnings, citing preteens and teenagers who hanged themselves or slashed their wrists shortly after starting the antidepressants. Parent after parent described children who had become extremely agitated or anxious shortly after starting the antidepressants, and seemingly sudden impulses that turned deadly. -------Kimberley Medlin--------- http://www.vaccinationsandsids.com/ ChristianityandVaccinations_AZvac-lib/ DiseasesandVaccinationsDatabase/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 24, 2004 Report Share Posted May 24, 2004 Les, Please resend link to latest release. Thanks, > SSRIs may cause suicide > Attached latest release > Cheers > Les > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 24, 2004 Report Share Posted May 24, 2004 Les, Please resend link to latest release. Thanks, > SSRIs may cause suicide > Attached latest release > Cheers > Les > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 25, 2004 Report Share Posted May 25, 2004 May 15, 2004 Medscape Alert Anti depressants May Cause Depression and Suicidality Yael Waknine March 22, 2004 — The U.S. Food and Drug Administration (FDA) has asked manufacturers of the several antidepressant drugs to include in their labeling a warning statement that recommends close observation of adult and pediatric patients treated with their agents for worsening depression or the emergence of suicidality The antidepressant drugs are fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox), citalopram (Celexa), escitalopram (Lexapro), bupropion (Wellbutrin), venlafaxine (Effexor), nefazodone (Serzone), and mirtazapine (Remeron). Several of these drugs are approved for the treatment of obsessive- compulsive disorder in pediatric patients (sertraline, fluoxetine, fluvoxamine). Only fluoxetine is approved for use in children with major depressive disorder. None of these drugs are approved as monotherapy in treating bipolar depression, either in adults or children, and fluvoxamine is not approved as an antidepressant in the U.S. The FDA has been closely reviewing the results of antidepressant studies in children since June 2003, after an initial report appeared to suggest increased risk of suicidal thoughts and actions in the pediatric population, according to today's advisory. Although it is unclear whether antidepressants contribute to the emergence of suicidal thinking and behavior, these interim actions are intended to draw more attention to the need for careful monitoring of patients being treated with these drugs, especially at the beginning of therapy and during dose changes. Discontinuation of medication may be appropriate in patients whose depression is persistently worse or whose emergent suicidality is severe, abrupt in onset, or was not part of the patient's presenting symptoms. Therapy changes should be made under the guidance of a physician, as certain medications should be tapered rather than stopped abruptly. The warning also alerts physicians, patients, and caregivers to symptoms such as anxiety, agitation, panic attacks, insomnia, irritability, hostility, impulsivity, akathisia, hypomania, and mania in patients being treated with antidepressants for major depressive disorder as well as other indications. According to the FDA, there is concern that patients who experience one or more of these symptoms may be at increased risk for worsening depression or suicidality. Because antidepressants are believed to have the potential for inducing manic episodes in patients with bipolar disorder, the FDA recommends that physicians be particularly vigilant in screening and monitoring patients who may be at risk. The FDA is continuing to review available clinical trial data for pediatric patients with depression and other psychiatric disorders to determine whether there is evidence that some or all antidepressants increase the risk of suicidality in children. Later this summer, the FDA plans to update the Psychopharmacological Drugs Advisory Committee (PDAC) and the Pediatric Subcommittee of the Anti-Infective Drugs Advisory Committee (Peds AC) about the results of this review. In the interim, the FDA plans to work closely with each of the nine manufacturers of the antidepressants involved to optimize safe drug use and implement proposed labeling changes and other safety communications in a timely manner. Reviewed by D. Vogin, MD Yael Waknine is a freelance writer for Medscape. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 10, 2008 Report Share Posted August 10, 2008 The problem with this notice is that even at 20 mgs, statins can damage your kidneys. phine > > This came to me today. I think that this is the beginning we are all > waiting for.Pamela > > The FDA is notifying the public of an increased risk of muscle > breakdown (rhabdomyolysis) when the cholesterol-lowering > medication simvastatin (marketed as Zocor and generics), > Ezetimibe/Simvastatin (marketed as Vytorin), or Niacin > Extended-Release /Simvastatin (marketed as Simcor), is used with > amiodarone (Cordarone, Pacerone), a drug used for abnormal heart > rhythms. Rhabdomyolysis is a rare condition which can lead to > kidney failure if not detected early. This risk is dose-related > and increases when a dose of simvastatin greater than 20 mg per > day is given with amiodarone. > > For more information, please visit: > http://www.fda.gov/cder/drug/InfoSheets/HCP/simvastatin_amiodaroneHCP.htm > > > > * * * * > WHAT DOES THIS MEAN? > > Although this FDA alert is about simvastatin and amiodarone, > other statins such as atorvastatin (Lipitor) or lovastatin > (Mevacor) are likely to be affected in the same way as > simvastatin when used with amiodarone. > > If you are taking either simvastatin, lovastatin or > atorvastatin, speak to you doctor about your risk of muscle > injury and what you can do to minimize your risks - especially > if you are also taking amiodarone. Some of the other statins > such as fluvastatin (Lescol), pravastatin (Pravachol), and > rosuvastatin (Crestor) may be safer alternatives in patients > receiving amiodarone, since they are metabolized differently. > > Keep in mind that muscle damage, although rare, is a risk of > using any statin - even if you are not taking amiodarone. Thus, > if you are taking a statin, promptly report to your doctor if > you experience any unexplained muscle pain, tenderness, or > weakness, particularly if accompanied by fever. > > For updated risk ratings on all of your registered medications, > or to update your medication list, please log into your profile > (https://secure.iGuard.org/user). You can also reach your > profile by clicking on the link in the top right corner of any > page on our web site. > > * * * * > PLEASE TELL YOUR FRIENDS > > We want to continually improve our service, and hope you want to > help us too. > > Please reply with any suggestions, ideas, comments or feedback > that we can use to make our service more valuable for you... And > don't forget to tell your friends and family about what we do! > > ============================== > DISCLAIMER > > iGuard is not intended to be a substitute for professional > medical advice. iGuard cannot and does not take into > consideration every possible interaction or account for > individual responses to medicine. Different individuals may > respond to medication in different ways. The absence of a > warning for a given drug or drug combination in no way should be > construed to indicate that the drug or drug combination is safe, > effective, or appropriate for any given patient. Always seek the > advice of a qualified health provider with any questions you may > have before making any changes to your treatment. The use of the > iGuard site and its content is at your own risk. © 2007 > iGuard.org. All rights reserved. iGuard.org, 66 Witherspoon St > #262, Princeton, NJ 08542. > > For more information about iGuard.org, please visit: > http://www.iGuard.org > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 10, 2008 Report Share Posted August 10, 2008 The problem with this notice is that even at 20 mgs, statins can damage your kidneys. phine > > This came to me today. I think that this is the beginning we are all > waiting for.Pamela > > The FDA is notifying the public of an increased risk of muscle > breakdown (rhabdomyolysis) when the cholesterol-lowering > medication simvastatin (marketed as Zocor and generics), > Ezetimibe/Simvastatin (marketed as Vytorin), or Niacin > Extended-Release /Simvastatin (marketed as Simcor), is used with > amiodarone (Cordarone, Pacerone), a drug used for abnormal heart > rhythms. Rhabdomyolysis is a rare condition which can lead to > kidney failure if not detected early. This risk is dose-related > and increases when a dose of simvastatin greater than 20 mg per > day is given with amiodarone. > > For more information, please visit: > http://www.fda.gov/cder/drug/InfoSheets/HCP/simvastatin_amiodaroneHCP.htm > > > > * * * * > WHAT DOES THIS MEAN? > > Although this FDA alert is about simvastatin and amiodarone, > other statins such as atorvastatin (Lipitor) or lovastatin > (Mevacor) are likely to be affected in the same way as > simvastatin when used with amiodarone. > > If you are taking either simvastatin, lovastatin or > atorvastatin, speak to you doctor about your risk of muscle > injury and what you can do to minimize your risks - especially > if you are also taking amiodarone. Some of the other statins > such as fluvastatin (Lescol), pravastatin (Pravachol), and > rosuvastatin (Crestor) may be safer alternatives in patients > receiving amiodarone, since they are metabolized differently. > > Keep in mind that muscle damage, although rare, is a risk of > using any statin - even if you are not taking amiodarone. Thus, > if you are taking a statin, promptly report to your doctor if > you experience any unexplained muscle pain, tenderness, or > weakness, particularly if accompanied by fever. > > For updated risk ratings on all of your registered medications, > or to update your medication list, please log into your profile > (https://secure.iGuard.org/user). You can also reach your > profile by clicking on the link in the top right corner of any > page on our web site. > > * * * * > PLEASE TELL YOUR FRIENDS > > We want to continually improve our service, and hope you want to > help us too. > > Please reply with any suggestions, ideas, comments or feedback > that we can use to make our service more valuable for you... And > don't forget to tell your friends and family about what we do! > > ============================== > DISCLAIMER > > iGuard is not intended to be a substitute for professional > medical advice. iGuard cannot and does not take into > consideration every possible interaction or account for > individual responses to medicine. Different individuals may > respond to medication in different ways. The absence of a > warning for a given drug or drug combination in no way should be > construed to indicate that the drug or drug combination is safe, > effective, or appropriate for any given patient. Always seek the > advice of a qualified health provider with any questions you may > have before making any changes to your treatment. The use of the > iGuard site and its content is at your own risk. © 2007 > iGuard.org. All rights reserved. iGuard.org, 66 Witherspoon St > #262, Princeton, NJ 08542. > > For more information about iGuard.org, please visit: > http://www.iGuard.org > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 10, 2008 Report Share Posted August 10, 2008 phine, Exactly how would one know their kidney's were being or had been damaged by statins? In other words, how would this be detected? Blood tests/blood values moving higher/lower? Steve jlkinkona wrote: > > > The problem with this notice is that even at 20 mgs, statins can > damage your kidneys. phine > > > > > > This came to me today. I think that this is the beginning we are all > > waiting for.Pamela > > > > The FDA is notifying the public of an increased risk of muscle > > breakdown (rhabdomyolysis) when the cholesterol-lowering > > medication simvastatin (marketed as Zocor and generics), > > Ezetimibe/Simvastatin (marketed as Vytorin), or Niacin > > Extended-Release /Simvastatin (marketed as Simcor), is used with > > amiodarone (Cordarone, Pacerone), a drug used for abnormal heart > > rhythms. Rhabdomyolysis is a rare condition which can lead to > > kidney failure if not detected early. This risk is dose-related > > and increases when a dose of simvastatin greater than 20 mg per > > day is given with amiodarone. > > > > For more information, please visit: > > > http://www.fda.gov/cder/drug/InfoSheets/HCP/simvastatin_amiodaroneHCP.htm > <http://www.fda.gov/cder/drug/InfoSheets/HCP/simvastatin_amiodaroneHCP.htm> > > > > > > > > * * * * > > WHAT DOES THIS MEAN? > > > > Although this FDA alert is about simvastatin and amiodarone, > > other statins such as atorvastatin (Lipitor) or lovastatin > > (Mevacor) are likely to be affected in the same way as > > simvastatin when used with amiodarone. > > > > If you are taking either simvastatin, lovastatin or > > atorvastatin, speak to you doctor about your risk of muscle > > injury and what you can do to minimize your risks - especially > > if you are also taking amiodarone. Some of the other statins > > such as fluvastatin (Lescol), pravastatin (Pravachol), and > > rosuvastatin (Crestor) may be safer alternatives in patients > > receiving amiodarone, since they are metabolized differently. > > > > Keep in mind that muscle damage, although rare, is a risk of > > using any statin - even if you are not taking amiodarone. Thus, > > if you are taking a statin, promptly report to your doctor if > > you experience any unexplained muscle pain, tenderness, or > > weakness, particularly if accompanied by fever. > > > > For updated risk ratings on all of your registered medications, > > or to update your medication list, please log into your profile > > (https://secure.iGuard.org/user <https://secure.iGuard.org/user>). > You can also reach your > > profile by clicking on the link in the top right corner of any > > page on our web site. > > > > * * * * > > PLEASE TELL YOUR FRIENDS > > > > We want to continually improve our service, and hope you want to > > help us too. > > > > Please reply with any suggestions, ideas, comments or feedback > > that we can use to make our service more valuable for you... And > > don't forget to tell your friends and family about what we do! > > > > ============================== > > DISCLAIMER > > > > iGuard is not intended to be a substitute for professional > > medical advice. iGuard cannot and does not take into > > consideration every possible interaction or account for > > individual responses to medicine. Different individuals may > > respond to medication in different ways. The absence of a > > warning for a given drug or drug combination in no way should be > > construed to indicate that the drug or drug combination is safe, > > effective, or appropriate for any given patient. Always seek the > > advice of a qualified health provider with any questions you may > > have before making any changes to your treatment. The use of the > > iGuard site and its content is at your own risk. © 2007 > > iGuard.org. All rights reserved. iGuard.org, 66 Witherspoon St > > #262, Princeton, NJ 08542. > > > > For more information about iGuard.org, please visit: > > http://www.iGuard.org <http://www.iGuard.org> > > -- Steve - dudescholar4@... Take World's Smallest Political Quiz at http://www.theadvocates.org/quiz.html " If a thousand old beliefs were ruined on our march to truth we must still march on. " --Stopford Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 10, 2008 Report Share Posted August 10, 2008 phine, Exactly how would one know their kidney's were being or had been damaged by statins? In other words, how would this be detected? Blood tests/blood values moving higher/lower? Steve jlkinkona wrote: > > > The problem with this notice is that even at 20 mgs, statins can > damage your kidneys. phine > > > > > > This came to me today. I think that this is the beginning we are all > > waiting for.Pamela > > > > The FDA is notifying the public of an increased risk of muscle > > breakdown (rhabdomyolysis) when the cholesterol-lowering > > medication simvastatin (marketed as Zocor and generics), > > Ezetimibe/Simvastatin (marketed as Vytorin), or Niacin > > Extended-Release /Simvastatin (marketed as Simcor), is used with > > amiodarone (Cordarone, Pacerone), a drug used for abnormal heart > > rhythms. Rhabdomyolysis is a rare condition which can lead to > > kidney failure if not detected early. This risk is dose-related > > and increases when a dose of simvastatin greater than 20 mg per > > day is given with amiodarone. > > > > For more information, please visit: > > > http://www.fda.gov/cder/drug/InfoSheets/HCP/simvastatin_amiodaroneHCP.htm > <http://www.fda.gov/cder/drug/InfoSheets/HCP/simvastatin_amiodaroneHCP.htm> > > > > > > > > * * * * > > WHAT DOES THIS MEAN? > > > > Although this FDA alert is about simvastatin and amiodarone, > > other statins such as atorvastatin (Lipitor) or lovastatin > > (Mevacor) are likely to be affected in the same way as > > simvastatin when used with amiodarone. > > > > If you are taking either simvastatin, lovastatin or > > atorvastatin, speak to you doctor about your risk of muscle > > injury and what you can do to minimize your risks - especially > > if you are also taking amiodarone. Some of the other statins > > such as fluvastatin (Lescol), pravastatin (Pravachol), and > > rosuvastatin (Crestor) may be safer alternatives in patients > > receiving amiodarone, since they are metabolized differently. > > > > Keep in mind that muscle damage, although rare, is a risk of > > using any statin - even if you are not taking amiodarone. Thus, > > if you are taking a statin, promptly report to your doctor if > > you experience any unexplained muscle pain, tenderness, or > > weakness, particularly if accompanied by fever. > > > > For updated risk ratings on all of your registered medications, > > or to update your medication list, please log into your profile > > (https://secure.iGuard.org/user <https://secure.iGuard.org/user>). > You can also reach your > > profile by clicking on the link in the top right corner of any > > page on our web site. > > > > * * * * > > PLEASE TELL YOUR FRIENDS > > > > We want to continually improve our service, and hope you want to > > help us too. > > > > Please reply with any suggestions, ideas, comments or feedback > > that we can use to make our service more valuable for you... And > > don't forget to tell your friends and family about what we do! > > > > ============================== > > DISCLAIMER > > > > iGuard is not intended to be a substitute for professional > > medical advice. iGuard cannot and does not take into > > consideration every possible interaction or account for > > individual responses to medicine. Different individuals may > > respond to medication in different ways. The absence of a > > warning for a given drug or drug combination in no way should be > > construed to indicate that the drug or drug combination is safe, > > effective, or appropriate for any given patient. Always seek the > > advice of a qualified health provider with any questions you may > > have before making any changes to your treatment. The use of the > > iGuard site and its content is at your own risk. © 2007 > > iGuard.org. All rights reserved. iGuard.org, 66 Witherspoon St > > #262, Princeton, NJ 08542. > > > > For more information about iGuard.org, please visit: > > http://www.iGuard.org <http://www.iGuard.org> > > -- Steve - dudescholar4@... Take World's Smallest Political Quiz at http://www.theadvocates.org/quiz.html " If a thousand old beliefs were ruined on our march to truth we must still march on. " --Stopford Quote Link to comment Share on other sites More sharing options...
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