Correlation of TLR1-10 expression in peripheral blood mononuclear cells with chronic hepatitis B and chronic hepatitis B-related liver failure

[Guest guest]

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6T3B-50M1RMF-2 & _user=1\

0 & _coverDate=10%2F31%2F2010 & _rdoc=4 & _fmt=high & _orig=browse & _origin=browse & _zone=\

rslt_list_item & _srch=doc-info(%23toc%234942%232010%23999289989%232384735%23FLA%2\

3display%23Volume) & _cdi=4942 & _sort=d & _docanchor= & _ct=20 & _acct=C000050221 & _versio\

n=1 & _urlVersion=0 & _userid=10 & md5=13515311459b9caf4e86ffa0730f0583 & searchtype=a

Human Immunology

Volume 71, Issue 10, October 2010, Pages 950-956

--------------------------------------------------------------------------------

doi:10.1016/j.humimm.2010.07.013 | How to Cite or Link Using DOI

Crown copyright © 2010 Published by Elsevier Inc. Cited By in Scopus (0)

Correlation of TLR1-10 expression in peripheral blood mononuclear cells with

chronic hepatitis B and chronic hepatitis B-related liver failure

Ke Wanga, Hongli Liu, a, , Yingli Hea, Tianyan Chena, Yuan Yanga, Yinghua Niua,

Hongmei Chena, Yunru Chena, Jinfeng Liua, Feng Yea, Shumei Lina and Yingren

Zhao, a,

a Department of Infectious Diseases, First Affiliated Hospital of Medical

College, Xi'an Jiaotong University, Shaanxi Province, China

Received 9 May 2010; accepted 12 July 2010. Available online 24 July 2010.

Available online 24 July 2010.

Abstract

Toll-like receptors (TLRs) promote host defenses against invading viruses and

pathogenic bacteria through corresponding adapter molecules leading to the

initiation of innate immune response. We investigated the expression of TLR1-10

in peripheral blood mononuclear cells (PBMCs) from patients with different

clinical phases of chronic hepatitis B (CHB) infection and analyzed the

correlation between TLRs and clinical profiles. Our results showed that

expression of TLR3/5/7/9/10 and TLR2/4/6 mRNA was upregulated in active stage of

CHB and CHB-related liver failure, respectively. Particularly we found that TLR9

mRNA expression is negatively correlated with serum alanine aminotransferase

(ALT), Tbil, PTA, and positively correlated with hepatitis B virus (HBV) viral

load in CHB patients. Our results indicate that innate immune responses are

significantly higher in CHB active phase than that in CHB-related liver failure,

suggesting TLRs may play a critical role in development of CHB and CHB-related

liver failure, the mechanisms need further to be further explored.