New perspectives for T cell-based hepatitis C vaccines are the focus of review

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Article Summary

New perspectives for T cell-based hepatitis C vaccines are the focus of

rev..

Vaccine Weekly - 30-Aug-2006

According to the review, " Three percent of the world's population is

chronically infected with the hepatitis C virus (HCV) and at risk of

developing liver cancer. Effective cellular immune responses are deemed

essential for spontaneous resolution of acute hepatitis C and long-term

protection. " Suppression of acute viremia in vaccinated chimpanzees occurred

as a result of massive expansion of peripheral and intrahepatic HCV-specific

CD8+ T lymphocytes that cross-reacted with vaccine and virus epitopes, " said

Carlo Ferrari at the University of Parma.

Summary

• New perspectives for T cell-based hepatitis C vaccines are the focus of

review

• According to the review, " Three percent of the world's population is

chronically infected with the hepatitis C virus (HCV) and at risk of

developing liver cancer.

• Effective cellular immune responses are deemed essential for spontaneous

resolution of acute hepatitis C and long-term protection.

• Here, we describe a new T-cell HCV genetic vaccine capable of protecting

chimpanzees from acute hepatitis induced by challenge with heterologous

virus. "

• " Suppression of acute viremia in vaccinated chimpanzees occurred as a

result of massive expansion of peripheral and intrahepatic HCV-specific CD8+

T lymphocytes that cross-reacted with vaccine and virus epitopes, " said

Carlo Ferrari at the University of Parma.

• " These findings show that it is possible to elicit effective immunity

against heterologous HCV strains by stimulating only the cellular arm of the

immune system, and suggest a path for new immunotherapy against highly

variable human pathogens like HCV, HIV, or malaria, which can evade humoral

responses, " stated the author.

• Ferrari published the review in the Journal of Hepatology (New

perspectives for T-cell-based HCV vaccines.

• J Hepatol, 2006;45(1):163-165).

http://www.therapeuticsdaily.com/news/summary.cfm?id=1061263 & channelID=31

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