HCV Research 20 Years After Discovery: A Summary of the 16th International Symposium on Hepatitis C Virus and Related Viruses

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http://www.gastrojournal.org/article/PIIS0016508509020356/abstract?rss=yes

GASTROENTEROLOGY

Volume 138, Issue 1, Pages 6-12.e2 (January 2010)

HCV Research 20 Years After Discovery: A Summary of the 16th International

Symposium on Hepatitis C Virus and Related Viruses

Jean–Michel Pawlotsky‡, ce Cocquerel§, Durantel∥¶#, Dimitri

Lavillette‡‡§§, Hervé Lerat‡, Eve–Isabelle Pécheur∥∥, J.

Polyak¶¶, Norbert Tautz##, Thimme

published online 19 November 2009.

The 16th International Symposium on Hepatitis C Virus and Related Viruses took

place in Nice, France, on October 3–7, 2009, almost exactly 20 years after

Houghton and colleagues reported discovery of the hepatitis C virus

(HCV). At that time, the disease was known as “non-A, non-B hepatitis,†and

its prevalence was underestimated. Now, approximately 170 million individuals

worldwide are infected; chronic HCV infection is the leading indication for

liver transplantation and one of the principal causes of primary liver cancer in

industrialized countries.

Abbreviations used in this paper: apo, apolipoprotein, CTLA-4, cytotoxic

T-lymphocyte antigen 4, ER, endoplasmic reticulum, GADD45β, growth arrest and

DNA damage-inducible 45β, GRE, GU-rich element, HVR1, hypervariable region 1,

IFN, interferon, IL, interleukin, IRF, interferon-regulatory factor, ISG,

interferon-stimulated gene, LNA, locked nucleic acid, LVP, lipo-viro-particle,

PD-1, programmed death 1, PKR, protein kinase RNA activated, RdRp, RNA-dependent

RNA polymerase, RIG-I, retinoic acid inducible gene I, siRNA, silencing RNA,

TGF, transforming growth factor, TLR, toll-like receptor

National Reference Center for Viral Hepatitis B, C and Delta, Department of

Virology, Henri Mondor Hospital, University of Paris 12, Créteil, France

‡ INSERM Unité 955, Créteil, France

§ Institut de Biologie de Lille, CNRS-UMR8161, Université Lille-Nord de

France, Institut Pasteur de Lille, Lille, France

∥ INSERM Unité 871, Molecular Physiopathology and New Treatment of Viral

Hepatitis, Lyon, France

¶ Université de Lyon, UCB-Lyon1, IFR62, Lyon, France

# Hospices Civils de Lyon, Lyon, France

Université de Lyon, UCB-Lyon1, IFR128, Lyon, France

‡‡ INSERM Unité 758, Lyon, France

§§ Ecole Normale Supérieure de Lyon, Lyon, France

∥∥ Institut de Biologie et Chimie des Protéines, UMR CNRS 5086, Université

Lyon 1, IFR128 Lyon Biosciences Gerland, Lyon, France

¶¶ Division of Virology, Department of Laboratory Medicine, University of

Washington School of Medicine, Seattle, Washington

## Institute of Virology and Cell Biology, University of Lübeck, Lübeck,

Germany

Department of Medicine II, University of Freiburg, Freiburg, Germany

Reprint requests Address requests for reprints to: Jean-Michel Pawlotsky, MD,

PhD, Department of Virology, Hôpital Henri Mondor, 51 avenue du Maréchal de

Lattre de Tassigny, 94010 Créteil, France. fax: (33) 1-4981-4831

Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)02035-6

doi:10.1053/j.gastro.2009.11.018

© 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.