Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population

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J Med Virol. 2010 Jan 19;82(3):371-378. [Epub ahead of print]

Association of candidate susceptible loci with chronic infection with hepatitis

B virus in a Chinese population.

Chen DQ, Zeng Y, Zhou J, Yang L, Jiang S, Huang JD, Lu L, Zheng BJ.

Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.

A number of genetic loci have been proposed to be associated with persistent

hepatitis B virus (HBV) infection. This study aimed to evaluate the association

and interaction of susceptible genes with HBV persistence in a Chinese

population. A total of 17 polymorphisms in 9 candidate genes were studied in 361

Chinese chronic hepatitis B patients and 304 patients who recovered

spontaneously. Distributions of susceptible polymorphisms were examined in

healthy Chinese and Caucasian populations. Gene-gene interactions were tested by

the multifactor dimensionality reduction (MDR) method. The TNF -308 G/G genotype

and G allele, IL-10RB codon 47 A allele, and MCP-1 -2518 G/G genotype and G

allele were more frequent in patients than controls (P < 0.01, after multiple

corrections Pc < 0.05), while the frequencies of TNF -308 A/G genotype and IL-10

-592 A/A genotype were significantly higher in controls than in the patient

group (Pc < 0.05). The frequencies of the risk allele MCP-1 -2518 G and CTLA4

6230 G were much higher in Chinese than in the Caucasian groups (P < 0.001). An

interaction between CCR5 -2459, TNFA -863, IL-10RB codon 47, and MCP-1 -2518 was

detected by MDR (P = 0.001). The results indicate that genetic determinants may

affect the outcome of HBV infection in both independent and synergic manners. J.

Med. Virol. 82:371-378, 2010. © 2010 Wiley-Liss, Inc.

PMID: 20087947 [PubMed - as supplied by publisher]