Correlation of liver biochemistry with liver stiffness in chronic hepatitis B and development of a predictive model for liver fibrosis

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http://www3.interscience.wiley.com/journal/120126022/abstract

Liver International

Volume 28 Issue 10, Pages 1408 - 1416

Published Online: 15 May 2008

CLINICAL STUDIES

Correlation of liver biochemistry with liver stiffness in chronic hepatitis B

and development of a predictive model for liver fibrosis

Fung 1 , Ching-Lung Lai 1 , Yee-Tak Fong 1 , Chi-Hang Yuen 1 ,

Danny Ka-Ho Wong 1 and Man-Fung Yuen 1

1 Department of Medicine, The University of Hong Kong, Queen Hospital,

Hong Kong SAR, Hong Kong

Correspondence

Assoc. Prof. Man-Fung Yuen, Department of Medicine, The University of Hong Kong,

Queen Hospital, Pokfulam Road, Hong Kong SAR, Hong Kong

Tel: 852 2855 3984

Fax: 852 2816 2863

e-mail: mfyuen@...

Copyright Journal compilation © 2008 Blackwell Munksgaard

KEYWORDS

chronic hepatitis B . fibrosis . liver biochemistry . liver stiffness .

transient elastography

ABSTRACT

Aim: To correlate liver stiffness with demographical factors and routine liver

biochemistry and to assess the predictive value of these as potential markers of

fibrosis.

Methods: Transient elastography was performed in 1268 chronic hepatitis B (CHB)

patients. According to a previous validated study for CHB, liver stiffness

of>8.1 and>10.3 kPa were used as cut-off values for defining severe fibrosis and

cirrhosis respectively.

Results: Liver stiffness correlated positively with bilirubin, alkaline

phosphatase (ALP), ã-glutamyl transpeptidase (GGT), aspartate aminotransferase

(AST), alanine aminotransferase (ALT), globulin, á-fetoprotein (AFP) and HBV DNA

levels and negatively with albumin and platelet levels (P