Solvent And Detergent Mix Thwarts Potential Virus Transmission

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Solvent And Detergent Mix Thwarts Potential Virus Transmission

Vox Sanguinis

07/25/2001

By Anne MacLennan

Solvent and detergent treatment does not alter the tolerance or uptake of

human normal immunoglobulin for intramuscular injection. Furthermore, this

treatment offers additional assurance against potential virus transmission.

This is the view of Dr G P Mould GP and colleagues from the Guildford

Clinical Pharmacology Unit, Royal Surrey County Hospital, Guildford, Surrey,

England after a study in 36 healthy volunteers.

The researchers set out to investigate and compare both the tolerability and

pharmacokinetics of a solvent- and detergent-treated intramuscular

immunoglobulin with those of the standard product.

In the study, researchers administered single 750-mg intramuscular (IM)

injections to a total of 36 healthy people, 23 of them in a double blind

trial format and 13 of them in an open trial.

Changes in specific serum hepatitis A and hepatitis B antibodies were then

monitored for a period of up to three months following the injections.

None of the study subjects reported having any serious adverse reactions.

Furthermore, the bioavailability of the solvent- and detergent-treated

preparation was found to be equivalent to that of the standard i.m.

immunoglobulin, study authors note.

Thus, there is no evidence this solvent and detergent treatment alters the

pharmacokinetics or tolerance of human normal immunoglobulin.

Moreover, this treatment has the added benefit of ensuring against potential

virus transmission, these researchers conclude.

Vox Sang 2001;80(3):151-8