Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Dear Amy: Depending on how you want to describe the genotypes, 1b, is not the one of choice, but, then again, you are part of the US majority. The 1a and 1b do not respond as easily to current therapy, ie: either do not respond at all, do not go into remission as easily, and may relapse more quickly. The whole issue of genotype is still one of controversy and depending on which study you read, and what they are trying to prove, will either depress you, or be meaningless. Since the genotype nor the results of the " biopsy " are parts of the protocol for current treatment, that could change in the future. I have treated many people who have a genotype of 1b, (about 75%), and the others have been mixed, depending on how they got the virus. I think this is one area that people should not read too much into yet, because we do not know enough. Some have responded excellently and there are people who have not shown a detectable viral load for 5-10 years, on current therapeutic regimes. Basically, the current treatment lengths, of the combo therapy has been to treat for 24 weeks, if the person can tolerate the therapy, and, if it is having some positive effects against keeping the viral loads down, and the liver enzymes from being elevated. If no real effect, then a person stops at 24 weeks. If genotype 1a or 1b, if you are responding, then you are usually placed on another 24 weeks. In reality, it is not a full " year " , but, a total of 48 weeks. Originally, there was some that went for 72 weeks if they were responding, but, that is not as frequently seen today. Also, a major factor is how your body tolerates the meds. You do not need to place HCV into a " non-detectable " state, and wind up with something worse because your blood counts are so low, you are either too anemic or too immunocompromised and you leave yourself open for additional problems. But, assuming that you progress " normally " , even if certain blood counts drop very low, and your provider about whether certain cell stimulating drugs would help, ie: Neupogen or Epogen, to increase your counts. This means another injection several times a week, but, it is better then stopping, or getting sicker. Just try to keep informed and take each day at a time. If you do not have confidence in your provider, speak to him/her, and if that does not solve the problem, find a new provider. This disease is tough enough without adding outside negative influences. Depression is usually seen, (beyond the normal " grieving " process), in most people, and has to be watched carefully beginning a round the 3rd month to 5-6 months, when it seems to have the most negative effects. I believe that a great deal of how a person responds is based on some type of psychological impact that we do not know, or understand enough about yet. But, a " state of mind " will definitely impact on any treatment or disease. I hope this helps some. Keep smiling. Marty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Dear Amy: Depending on how you want to describe the genotypes, 1b, is not the one of choice, but, then again, you are part of the US majority. The 1a and 1b do not respond as easily to current therapy, ie: either do not respond at all, do not go into remission as easily, and may relapse more quickly. The whole issue of genotype is still one of controversy and depending on which study you read, and what they are trying to prove, will either depress you, or be meaningless. Since the genotype nor the results of the " biopsy " are parts of the protocol for current treatment, that could change in the future. I have treated many people who have a genotype of 1b, (about 75%), and the others have been mixed, depending on how they got the virus. I think this is one area that people should not read too much into yet, because we do not know enough. Some have responded excellently and there are people who have not shown a detectable viral load for 5-10 years, on current therapeutic regimes. Basically, the current treatment lengths, of the combo therapy has been to treat for 24 weeks, if the person can tolerate the therapy, and, if it is having some positive effects against keeping the viral loads down, and the liver enzymes from being elevated. If no real effect, then a person stops at 24 weeks. If genotype 1a or 1b, if you are responding, then you are usually placed on another 24 weeks. In reality, it is not a full " year " , but, a total of 48 weeks. Originally, there was some that went for 72 weeks if they were responding, but, that is not as frequently seen today. Also, a major factor is how your body tolerates the meds. You do not need to place HCV into a " non-detectable " state, and wind up with something worse because your blood counts are so low, you are either too anemic or too immunocompromised and you leave yourself open for additional problems. But, assuming that you progress " normally " , even if certain blood counts drop very low, and your provider about whether certain cell stimulating drugs would help, ie: Neupogen or Epogen, to increase your counts. This means another injection several times a week, but, it is better then stopping, or getting sicker. Just try to keep informed and take each day at a time. If you do not have confidence in your provider, speak to him/her, and if that does not solve the problem, find a new provider. This disease is tough enough without adding outside negative influences. Depression is usually seen, (beyond the normal " grieving " process), in most people, and has to be watched carefully beginning a round the 3rd month to 5-6 months, when it seems to have the most negative effects. I believe that a great deal of how a person responds is based on some type of psychological impact that we do not know, or understand enough about yet. But, a " state of mind " will definitely impact on any treatment or disease. I hope this helps some. Keep smiling. Marty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Dear Amy: Depending on how you want to describe the genotypes, 1b, is not the one of choice, but, then again, you are part of the US majority. The 1a and 1b do not respond as easily to current therapy, ie: either do not respond at all, do not go into remission as easily, and may relapse more quickly. The whole issue of genotype is still one of controversy and depending on which study you read, and what they are trying to prove, will either depress you, or be meaningless. Since the genotype nor the results of the " biopsy " are parts of the protocol for current treatment, that could change in the future. I have treated many people who have a genotype of 1b, (about 75%), and the others have been mixed, depending on how they got the virus. I think this is one area that people should not read too much into yet, because we do not know enough. Some have responded excellently and there are people who have not shown a detectable viral load for 5-10 years, on current therapeutic regimes. Basically, the current treatment lengths, of the combo therapy has been to treat for 24 weeks, if the person can tolerate the therapy, and, if it is having some positive effects against keeping the viral loads down, and the liver enzymes from being elevated. If no real effect, then a person stops at 24 weeks. If genotype 1a or 1b, if you are responding, then you are usually placed on another 24 weeks. In reality, it is not a full " year " , but, a total of 48 weeks. Originally, there was some that went for 72 weeks if they were responding, but, that is not as frequently seen today. Also, a major factor is how your body tolerates the meds. You do not need to place HCV into a " non-detectable " state, and wind up with something worse because your blood counts are so low, you are either too anemic or too immunocompromised and you leave yourself open for additional problems. But, assuming that you progress " normally " , even if certain blood counts drop very low, and your provider about whether certain cell stimulating drugs would help, ie: Neupogen or Epogen, to increase your counts. This means another injection several times a week, but, it is better then stopping, or getting sicker. Just try to keep informed and take each day at a time. If you do not have confidence in your provider, speak to him/her, and if that does not solve the problem, find a new provider. This disease is tough enough without adding outside negative influences. Depression is usually seen, (beyond the normal " grieving " process), in most people, and has to be watched carefully beginning a round the 3rd month to 5-6 months, when it seems to have the most negative effects. I believe that a great deal of how a person responds is based on some type of psychological impact that we do not know, or understand enough about yet. But, a " state of mind " will definitely impact on any treatment or disease. I hope this helps some. Keep smiling. Marty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Dear Amy: Depending on how you want to describe the genotypes, 1b, is not the one of choice, but, then again, you are part of the US majority. The 1a and 1b do not respond as easily to current therapy, ie: either do not respond at all, do not go into remission as easily, and may relapse more quickly. The whole issue of genotype is still one of controversy and depending on which study you read, and what they are trying to prove, will either depress you, or be meaningless. Since the genotype nor the results of the " biopsy " are parts of the protocol for current treatment, that could change in the future. I have treated many people who have a genotype of 1b, (about 75%), and the others have been mixed, depending on how they got the virus. I think this is one area that people should not read too much into yet, because we do not know enough. Some have responded excellently and there are people who have not shown a detectable viral load for 5-10 years, on current therapeutic regimes. Basically, the current treatment lengths, of the combo therapy has been to treat for 24 weeks, if the person can tolerate the therapy, and, if it is having some positive effects against keeping the viral loads down, and the liver enzymes from being elevated. If no real effect, then a person stops at 24 weeks. If genotype 1a or 1b, if you are responding, then you are usually placed on another 24 weeks. In reality, it is not a full " year " , but, a total of 48 weeks. Originally, there was some that went for 72 weeks if they were responding, but, that is not as frequently seen today. Also, a major factor is how your body tolerates the meds. You do not need to place HCV into a " non-detectable " state, and wind up with something worse because your blood counts are so low, you are either too anemic or too immunocompromised and you leave yourself open for additional problems. But, assuming that you progress " normally " , even if certain blood counts drop very low, and your provider about whether certain cell stimulating drugs would help, ie: Neupogen or Epogen, to increase your counts. This means another injection several times a week, but, it is better then stopping, or getting sicker. Just try to keep informed and take each day at a time. If you do not have confidence in your provider, speak to him/her, and if that does not solve the problem, find a new provider. This disease is tough enough without adding outside negative influences. Depression is usually seen, (beyond the normal " grieving " process), in most people, and has to be watched carefully beginning a round the 3rd month to 5-6 months, when it seems to have the most negative effects. I believe that a great deal of how a person responds is based on some type of psychological impact that we do not know, or understand enough about yet. But, a " state of mind " will definitely impact on any treatment or disease. I hope this helps some. Keep smiling. Marty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Thanks, Marty for what you said. I under stand a little more about genotypes. Their is just so much to keep up with. You put it where I could understand Thank you again Jessie, I do try to live one day at a time. EZ-DOES IT Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Thanks, Marty for what you said. I under stand a little more about genotypes. Their is just so much to keep up with. You put it where I could understand Thank you again Jessie, I do try to live one day at a time. EZ-DOES IT Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Thanks, Marty for what you said. I under stand a little more about genotypes. Their is just so much to keep up with. You put it where I could understand Thank you again Jessie, I do try to live one day at a time. EZ-DOES IT Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2000 Report Share Posted February 6, 2000 Thanks, Marty for what you said. I under stand a little more about genotypes. Their is just so much to keep up with. You put it where I could understand Thank you again Jessie, I do try to live one day at a time. EZ-DOES IT Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2000 Report Share Posted February 7, 2000 In a message dated 2/6/00 9:33:55 PM Central Standard Time, byteme@... writes: << and the others have been mixed, depending on how they got the virus >> Hello, can you please explain further on that? I have always thought it depended on the genotype from the person one got contaminated with. If I'm understanding what you said correctly, since I'm a 2b, and I got Hep C from blood transfusions, does that mean that almost every one else who got a transfusion is a 2b? This doesn't sound right....I think I've missed something somewhere. Thanks, Betty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2000 Report Share Posted February 9, 2000 Hi Betty Got HCV from bood transfusion during surger at famous Los Angeles hospital in 1980 and I am genotype " 1b. " Re: Re: Genotypes >From: Arkhepcgal@... > >In a message dated 2/6/00 9:33:55 PM Central Standard Time, >byteme@... writes: > ><< and the others have been mixed, depending on how they got the virus >> > >Hello, can you please explain further on that? I have always thought it >depended on the genotype from the person one got contaminated with. If I'm >understanding what you said correctly, since I'm a 2b, and I got Hep C from >blood transfusions, does that mean that almost every one else who got a >transfusion is a 2b? This doesn't sound right....I think I've missed >something somewhere. >Thanks, >Betty > >--------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2000 Report Share Posted February 9, 2000 Hi Betty Got HCV from bood transfusion during surger at famous Los Angeles hospital in 1980 and I am genotype " 1b. " Re: Re: Genotypes >From: Arkhepcgal@... > >In a message dated 2/6/00 9:33:55 PM Central Standard Time, >byteme@... writes: > ><< and the others have been mixed, depending on how they got the virus >> > >Hello, can you please explain further on that? I have always thought it >depended on the genotype from the person one got contaminated with. If I'm >understanding what you said correctly, since I'm a 2b, and I got Hep C from >blood transfusions, does that mean that almost every one else who got a >transfusion is a 2b? This doesn't sound right....I think I've missed >something somewhere. >Thanks, >Betty > >--------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2000 Report Share Posted February 9, 2000 Hi Betty Got HCV from bood transfusion during surger at famous Los Angeles hospital in 1980 and I am genotype " 1b. " Re: Re: Genotypes >From: Arkhepcgal@... > >In a message dated 2/6/00 9:33:55 PM Central Standard Time, >byteme@... writes: > ><< and the others have been mixed, depending on how they got the virus >> > >Hello, can you please explain further on that? I have always thought it >depended on the genotype from the person one got contaminated with. If I'm >understanding what you said correctly, since I'm a 2b, and I got Hep C from >blood transfusions, does that mean that almost every one else who got a >transfusion is a 2b? This doesn't sound right....I think I've missed >something somewhere. >Thanks, >Betty > >--------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2000 Report Share Posted February 9, 2000 Hi Betty Got HCV from bood transfusion during surger at famous Los Angeles hospital in 1980 and I am genotype " 1b. " Re: Re: Genotypes >From: Arkhepcgal@... > >In a message dated 2/6/00 9:33:55 PM Central Standard Time, >byteme@... writes: > ><< and the others have been mixed, depending on how they got the virus >> > >Hello, can you please explain further on that? I have always thought it >depended on the genotype from the person one got contaminated with. If I'm >understanding what you said correctly, since I'm a 2b, and I got Hep C from >blood transfusions, does that mean that almost every one else who got a >transfusion is a 2b? This doesn't sound right....I think I've missed >something somewhere. >Thanks, >Betty > >--------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 13, 2000 Report Share Posted February 13, 2000 .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 13, 2000 Report Share Posted February 13, 2000 .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Connie, Thank you very much for replying. & Tom Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Connie, Thank you very much for replying. & Tom Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Hi and welcome to you and your husband. :-), Like you said about the benefit, yes if you have it, it is good it is Genotype 3. There are others here who get into the more technical things and will let you know. I just wanted to say, Welcome to the list and that I will keep my fingers crossed for you and I wish you Good Luck, Take Care, Connie bigrigtom1@... wrote: Hello, My name is and 2 years ago we found out my husband has HCV. With in the last 2 months he has had an ultrasound, blood work and last week a liver biopsy. We go to the specialist tomorrow to find out the biopsy results and what he is a candidate for. He definitely has had this virus for at least 10 years. We picked up his blood work today to take tomorrow and it shows he is a Genotype 3a. We have been lurking on the list and we share all your feelings and concerns with this dreaded virus. Wish us luck tomorrow for our app. If I am understanding correctly Genotype 3a is to his benefit if there is such a thing with this virus! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Hi and welcome to you and your husband. :-), Like you said about the benefit, yes if you have it, it is good it is Genotype 3. There are others here who get into the more technical things and will let you know. I just wanted to say, Welcome to the list and that I will keep my fingers crossed for you and I wish you Good Luck, Take Care, Connie bigrigtom1@... wrote: Hello, My name is and 2 years ago we found out my husband has HCV. With in the last 2 months he has had an ultrasound, blood work and last week a liver biopsy. We go to the specialist tomorrow to find out the biopsy results and what he is a candidate for. He definitely has had this virus for at least 10 years. We picked up his blood work today to take tomorrow and it shows he is a Genotype 3a. We have been lurking on the list and we share all your feelings and concerns with this dreaded virus. Wish us luck tomorrow for our app. If I am understanding correctly Genotype 3a is to his benefit if there is such a thing with this virus! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Hi and welcome to you and your husband. :-), Like you said about the benefit, yes if you have it, it is good it is Genotype 3. There are others here who get into the more technical things and will let you know. I just wanted to say, Welcome to the list and that I will keep my fingers crossed for you and I wish you Good Luck, Take Care, Connie bigrigtom1@... wrote: Hello, My name is and 2 years ago we found out my husband has HCV. With in the last 2 months he has had an ultrasound, blood work and last week a liver biopsy. We go to the specialist tomorrow to find out the biopsy results and what he is a candidate for. He definitely has had this virus for at least 10 years. We picked up his blood work today to take tomorrow and it shows he is a Genotype 3a. We have been lurking on the list and we share all your feelings and concerns with this dreaded virus. Wish us luck tomorrow for our app. If I am understanding correctly Genotype 3a is to his benefit if there is such a thing with this virus! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Hi and welcome to you and your husband. :-), Like you said about the benefit, yes if you have it, it is good it is Genotype 3. There are others here who get into the more technical things and will let you know. I just wanted to say, Welcome to the list and that I will keep my fingers crossed for you and I wish you Good Luck, Take Care, Connie bigrigtom1@... wrote: Hello, My name is and 2 years ago we found out my husband has HCV. With in the last 2 months he has had an ultrasound, blood work and last week a liver biopsy. We go to the specialist tomorrow to find out the biopsy results and what he is a candidate for. He definitely has had this virus for at least 10 years. We picked up his blood work today to take tomorrow and it shows he is a Genotype 3a. We have been lurking on the list and we share all your feelings and concerns with this dreaded virus. Wish us luck tomorrow for our app. If I am understanding correctly Genotype 3a is to his benefit if there is such a thing with this virus! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Hello: : Yes, if you are going to have this virus 3a is one of the easier forms to clear. I have/had genotype 3a but after 1 year of treatment I'm undetectable for the last almost two years now. So good luck to you and yours. Take care, Les Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 Hello: : Yes, if you are going to have this virus 3a is one of the easier forms to clear. I have/had genotype 3a but after 1 year of treatment I'm undetectable for the last almost two years now. So good luck to you and yours. Take care, Les Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 , Best of luck at your doctors appt. My son has had the virus for 13 years. Let me know how you make out with the biopsy report. in Newport RI Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 10, 2001 Report Share Posted April 10, 2001 , Best of luck at your doctors appt. My son has had the virus for 13 years. Let me know how you make out with the biopsy report. in Newport RI Quote Link to comment Share on other sites More sharing options...
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