Inherited multicentric osteolysis

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Inherited multicentric osteolysis: case report of three siblings treated

with bisphosphonate.

http://7thspace.com/headlines/341693/inherited_multicentric_osteolysis_case_repo\

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Author: Senq-J LeeColin Whitewood Murray

Credits/Source: Pediatric Rheumatology 2010, 8:12

Inherited Multicentric Osteolysis (IMO) is an uncommon familial condition of

idiopathic pathophysiology causing bone osteolysis and dysplasia. These

patients present with common rheumatologic complaints of pain, dysfunction

and disability, and are often initially misdiagnosed as a chronic rheumatic

disease of childhood such as juvenile idiopathic arthritis.

We report a case of three siblings diagnosed with IMO. Diagnosis was made

during childhood, with each sibling having different manifestations and

course of disease.

One had a previous history of bilateral hip dysplasia. Two had osteolysis of

the foot, distal tibia and femur (lower limb bones), whilst one had

osteolysis of the rib and unusual clavicular fractures.

Unusually, all siblings appear to experience decreased pain sensation

compared to norms. All siblings were treated with bisphosphonates and

experienced a rapid improvement in pain symptoms, decreased analgesic

requirements.

Two had bone mineral density testing performed and both had increases

post-bisphosphonate. In all three, there was subjective evidence of

stabilisation of bone disease.

Testing for matrix metalloproteinase-2 (MMP2) gene was negative.