Fw: Low molecular weight silicones in blood of SBI patients

[Guest guest]

From: ilena rose <ilena@...>

Sent: Wednesday, February 28, 2001 1:59 AM

Subject: Low molecular weight silicones in blood of SBI patients

> ~~~ thanks ruby ~~~

>

> Determination of low molecular weight silicones in

> plasma and blood of women after exposure to silicone

> breast implants by GC/MS.

>

> Flassbeck D, Pfleiderer B, Grumping R, Hirner AV.

>

> Anal Chem. 2001 Feb 1;73(3):606-11.

> [MEDLINE record in process]

> PMID: 11217769

> Boo

> Institute of Environmental Analytical Chemistry,

> University of Essen, Germany.

>

>

> A sensitive, one-step sample preparation method for

> detection of volatile, low molecular weight (LMW) cyclic

> silicones hexamethylcyclotrisiloxane (D3), octamethyl-

> cyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5),

> and dodecamethylcyclohexasiloxane (D6) in plasma and blood

> using gas chromatography coupled with mass spectrometry (

> GC/MS, SIM mode) is presented. In spiked experiments,

> extraction efficiencies for these siloxanes (100-20 000 ng/mL)

> were approximately 90% for plasma and approximately 80%

> for blood; only in the case of D3 was the recovery very

> low. Plasma and blood of women who are or were exposed to

> silicone gel-filled implants and of control subjects were

> analyzed for low molecular weight silicones. D3-D6 were

> not detectable in control plasma or blood.

>

> Although the investigated numbers of patients samples

> are very limited, and thus, no statistical analysis is

> possible, our data clearly show a general increase in

> the amount of LMW cyclic siloxanes in the bodies of

> women with silicone implants.

>

> In particular, several years after ruptured silicone

> implants were removed, siloxanes could still be

> found in blood samples from several women. Siloxane

> compound D3 varied between 6 and 12 ng/mL (plasma) and

> between 20 and 28 ng/mL (blood), whereas the concentration

> range of D4 was 14-50 ng/mL (plasma) and 79-92 ng/mL

> (blood). D5 and D6, with one exception, could not be

> detected.

>

> PMID: 11217769

>

>

>