Re: Enbrel/Methotrexate questions - - for a three/four year old!

[Guest guest]

Becki-

My daughter took mtx from the time she was 2 until around age 4 (at 7 she is

back on it, but for iritis). She has pauci also. However, NSAIDs were not

controlling it and she went quickly from one joint affected to 4, so mtx was

deemed appropriate. She has never had any problems with it at all and it put

her into a remission which continues today. Hope this helps.

Diane (, 7, pauci in remission, iritis)

[Guest guest]

Hi Becky,

I'm sorry to hear that your daughter is not at her best right now.

My daughter is almost 2 and has been on methotrexate for about 10

months. It took about 3 months for it to start working, and she did

well on it for a while, but is now back to having swollen joints,

rashes and fevers-she's systemic. She's had no bad side effects from

the mtx-just a little less hungry the day after her shot, and maybe

some slight hair loss.

Our daughter is still on prednisone-has been since onset, so we are

also considering Enbrel in addition to the mtx to get her off the

pred. So I'm wondering too-anyone have experience with a little one

on Enbrel, and how did it work? any systemics have good

experiences? (Are there any biologics approved for a 2 year old?)

And just because I'm full of questions today, do joint injections

tend to work better with Enbrel, or about the same as without?

Sorry I couldn't be more help in answering your questions Becky-

although I'm sure others will chime in. Hoping Abby tapers off the

pred with no need for additional meds.

And thanks to everyone else for sharing their experiences.

Tracey (Madi, 22mo. systemic)

>

> Hello,

>

> We are at a point where we are considering stronger medications for

our

> daughter (Pauci, 3 years old). She has been experiencing fevers

and

> stiffness. Since this started back up, we have had her on

Predisone - -

> which has helped tremendously. She also takes Naproxen twice a

day.

> We are now going to slowly take her off of the Pred. to see what

> happens. If she starts back to feeling extra stiff and having

fevers,

> we are to consider Methotrexate, Enbrel or just a cortisone shot in

the

> knee (though it seems that the knee that we have been treating

since

> September is looking and moving better thanks to the Naproxen and

lots

> of PT).

>

> I'm trying to find out if anyone else has had their young children

on

> these medications and what their experiences have been. Our

daughter

> will be four at the end of January. The flyer that comes with

Enbrel

> says that it is for safe for children over four - - she is not

quite

> four and weighs about 30 pounds. It also says that it is for

children

> with Poly JRA, which she doesn't have . . . so I'm wondering . . .

are

> other young children out there with Pauci taking these

medications?

> How do they seem to work?

>

> Thanks for your help!

>

> Becky (Abby, pauci, 3)

>

[Guest guest]

Hi Tracey,

My daughter is on mtx and enbrel, and she is a systemic.

Unfortunately, she is not in your daughter's age range, but I can

give you our experiences with enbrel. n is 17 and came down

with systemic JRA at age 10. She is better on the combination of

enbrel/mtx, than she was on mtx alone. We were getting joint

injections every 3 months when she was only on mtx. When enbrel was

added she would go about a year at a time between injections. I

can't say if they worked better, or if the enbrel just controlled her

arthritis better. n isn't perfect with her current

medications. I would like her to move to kineret, but I can't talk

her into daily injections. She is not on prednisone.

It is very rare that a systemic is controlled with mtx only, or least

that has been my experience. Good luck. (n, systemic,17)

On Jan 4, 2007, at 12:35 PM, ztaimw wrote:

> Hi Becky,

>

> I'm sorry to hear that your daughter is not at her best right now.

> My daughter is almost 2 and has been on methotrexate for about 10

> months. It took about 3 months for it to start working, and she did

> well on it for a while, but is now back to having swollen joints,

> rashes and fevers-she's systemic. She's had no bad side effects from

> the mtx-just a little less hungry the day after her shot, and maybe

> some slight hair loss.

>

> Our daughter is still on prednisone-has been since onset, so we are

> also considering Enbrel in addition to the mtx to get her off the

> pred. So I'm wondering too-anyone have experience with a little one

> on Enbrel, and how did it work? any systemics have good

> experiences? (Are there any biologics approved for a 2 year old?)

> And just because I'm full of questions today, do joint injections

> tend to work better with Enbrel, or about the same as without?

>

> Sorry I couldn't be more help in answering your questions Becky-

> although I'm sure others will chime in. Hoping Abby tapers off the

> pred with no need for additional meds.

>

> And thanks to everyone else for sharing their experiences.

>

> Tracey (Madi, 22mo. systemic)

>

>

> >

> > Hello,

> >

> > We are at a point where we are considering stronger medications for

> our

> > daughter (Pauci, 3 years old). She has been experiencing fevers

> and

> > stiffness. Since this started back up, we have had her on

> Predisone - -

> > which has helped tremendously. She also takes Naproxen twice a

> day.

> > We are now going to slowly take her off of the Pred. to see what

> > happens. If she starts back to feeling extra stiff and having

> fevers,

> > we are to consider Methotrexate, Enbrel or just a cortisone shot in

> the

> > knee (though it seems that the knee that we have been treating

> since

> > September is looking and moving better thanks to the Naproxen and

> lots

> > of PT).

> >

> > I'm trying to find out if anyone else has had their young children

> on

> > these medications and what their experiences have been. Our

> daughter

> > will be four at the end of January. The flyer that comes with

> Enbrel

> > says that it is for safe for children over four - - she is not

> quite

> > four and weighs about 30 pounds. It also says that it is for

> children

> > with Poly JRA, which she doesn't have . . . so I'm wondering . . .

> are

> > other young children out there with Pauci taking these

> medications?

> > How do they seem to work?

> >

> > Thanks for your help!

> >

> > Becky (Abby, pauci, 3)

> >

>

>

>

[Guest guest]

Hi...chiming in here...Becki who visits this list, has a son with

systemic onset, who I believe went on Enbrel at the age of 2..he was a

very severe case of systemic onset JRA and Enbrel added to the mtx was a

miracle drug for him. I hope that she'll chime in soon...

and Rob 17 Spondy

On Thu, 04 Jan 2007 20:35:03 -0000 " ztaimw " <nsigns@...> writes:

Hi Becky,

I'm sorry to hear that your daughter is not at her best right now.

My daughter is almost 2 and has been on methotrexate for about 10

months. It took about 3 months for it to start working, and she did

well on it for a while, but is now back to having swollen joints,

rashes and fevers-she's systemic. She's had no bad side effects from

the mtx-just a little less hungry the day after her shot, and maybe

some slight hair loss.

Our daughter is still on prednisone-has been since onset, so we are

also considering Enbrel in addition to the mtx to get her off the

pred. So I'm wondering too-anyone have experience with a little one

on Enbrel, and how did it work? any systemics have good

experiences? (Are there any biologics approved for a 2 year old?)

And just because I'm full of questions today, do joint injections

tend to work better with Enbrel, or about the same as without?

Sorry I couldn't be more help in answering your questions Becky-

although I'm sure others will chime in. Hoping Abby tapers off the

pred with no need for additional meds.

And thanks to everyone else for sharing their experiences.

Tracey (Madi, 22mo. systemic)

>

> Hello,

>

> We are at a point where we are considering stronger medications for

our

> daughter (Pauci, 3 years old). She has been experiencing fevers

and

> stiffness. Since this started back up, we have had her on

Predisone - -

> which has helped tremendously. She also takes Naproxen twice a

day.

> We are now going to slowly take her off of the Pred. to see what

> happens. If she starts back to feeling extra stiff and having

fevers,

> we are to consider Methotrexate, Enbrel or just a cortisone shot in

the

> knee (though it seems that the knee that we have been treating

since

> September is looking and moving better thanks to the Naproxen and

lots

> of PT).

>

> I'm trying to find out if anyone else has had their young children

on

> these medications and what their experiences have been. Our

daughter

> will be four at the end of January. The flyer that comes with

Enbrel

> says that it is for safe for children over four - - she is not

quite

> four and weighs about 30 pounds. It also says that it is for

children

> with Poly JRA, which she doesn't have . . . so I'm wondering . . .

are

> other young children out there with Pauci taking these

medications?

> How do they seem to work?

>

> Thanks for your help!

>

> Becky (Abby, pauci, 3)

>

[Guest guest]

Hi Becky,

Becki here.My son is systemic,so not pauci either.

was diagnosed a month before his 3rd birthday.By the time he was 4 he

was maxed out on 25mg sub q MTX,200mg Plaquenil and 300mg Ibuprofen 3x a day

plus the pred daily between 30mg to 6mg.Two ankle injections within 3 months,and

at the ripe old age of 4yrs and 2months they added .45mg Enbrel 2x weekly.

Because of the constant use of steroids for 21 months also weighed 62.4

lbs when he started Enbrel.All of Abby's doses would be much lower.

Don't let Enbrel's FDA thing about 4 and up scare you.That was the youngest

age allowed in the original drug trials back in 2000.

I hope Abby does well with whatever you decide to try.

Becki and 8 systemic

[Guest guest]

Hi,

I don't post often, but do read all the posts daily. My daughter is 4 and she

has been on mtx since she was 2 and then Enbrel was added when she was 3. She is

poly and Enbrel has been a miracle drug for her. The NSAIDs just didn't do it

for her nor the mtx alone so the Enbrel was added and it has been great! They

now say she is in medicated remission and we have been able to cut back very

small amount on the mtx. If things continue the same when we go back in March,

they will cut back some more. Kaylee has had almost no side affects from mtx or

Enbrel. She feels a little sick the day after her injections, but otherwise she

has been okay.

and Kaylee, 4, Poly

Re: Enbrel/Methotrexate questions - - for a three/four year old!

Hi Becky,

I'm sorry to hear that your daughter is not at her best right now.

My daughter is almost 2 and has been on methotrexate for about 10

months. It took about 3 months for it to start working, and she did

well on it for a while, but is now back to having swollen joints,

rashes and fevers-she's systemic. She's had no bad side effects from

the mtx-just a little less hungry the day after her shot, and maybe

some slight hair loss.

Our daughter is still on prednisone-has been since onset, so we are

also considering Enbrel in addition to the mtx to get her off the

pred. So I'm wondering too-anyone have experience with a little one

on Enbrel, and how did it work? any systemics have good

experiences? (Are there any biologics approved for a 2 year old?)

And just because I'm full of questions today, do joint injections

tend to work better with Enbrel, or about the same as without?

Sorry I couldn't be more help in answering your questions Becky-

although I'm sure others will chime in. Hoping Abby tapers off the

pred with no need for additional meds.

And thanks to everyone else for sharing their experiences.

Tracey (Madi, 22mo. systemic)

>

> Hello,

>

> We are at a point where we are considering stronger medications for

our

> daughter (Pauci, 3 years old). She has been experiencing fevers

and

> stiffness. Since this started back up, we have had her on

Predisone - -

> which has helped tremendously. She also takes Naproxen twice a

day.

> We are now going to slowly take her off of the Pred. to see what

> happens. If she starts back to feeling extra stiff and having

fevers,

> we are to consider Methotrexate, Enbrel or just a cortisone shot in

the

> knee (though it seems that the knee that we have been treating

since

> September is looking and moving better thanks to the Naproxen and

lots

> of PT).

>

> I'm trying to find out if anyone else has had their young children

on

> these medications and what their experiences have been. Our

daughter

> will be four at the end of January. The flyer that comes with

Enbrel

> says that it is for safe for children over four - - she is not

quite

> four and weighs about 30 pounds. It also says that it is for

children

> with Poly JRA, which she doesn't have . . . so I'm wondering . . .

are

> other young children out there with Pauci taking these

medications?

> How do they seem to work?

>

> Thanks for your help!

>

> Becky (Abby, pauci, 3)

>

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[Guest guest]

Hi my daughter who has poly. was put on mtx when she was 1 yr. , she

would still get flair ups 2 to 3 times a year. When she could not

hardly move anymore she had steriod injections. That did wonders for

her. When she was 3yr. The mtx was not working so well for her and

the doctor kept uping the med., to the point she was at a max. what

a child could take. We had to take her off the mtx because her liver

was getting bad and she was turning yellow. So at 4 yr. she was put

on enbrel. It has done wonders for her. Hardly no flair ups

anymore.The only problem we have now is the iritis which came on

after she was taken off the mtx. My dauughter will me 8 in march.

Ann

>

> Hello,

>

> We are at a point where we are considering stronger medications

for our

> daughter (Pauci, 3 years old). She has been experiencing fevers

and

> stiffness. Since this started back up, we have had her on

Predisone - -

> which has helped tremendously. She also takes Naproxen twice a

day.

> We are now going to slowly take her off of the Pred. to see what

> happens. If she starts back to feeling extra stiff and having

fevers,

> we are to consider Methotrexate, Enbrel or just a cortisone shot

in the

> knee (though it seems that the knee that we have been treating

since

> September is looking and moving better thanks to the Naproxen and

lots

> of PT).

>

> I'm trying to find out if anyone else has had their young children

on

> these medications and what their experiences have been. Our

daughter

> will be four at the end of January. The flyer that comes with

Enbrel

> says that it is for safe for children over four - - she is not

quite

> four and weighs about 30 pounds. It also says that it is for

children

> with Poly JRA, which she doesn't have . . . so I'm wondering . . .

are

> other young children out there with Pauci taking these

medications?

> How do they seem to work?

>

> Thanks for your help!

>

> Becky (Abby, pauci, 3)

>