OT: Severe Hypersensitivity Reaction to Ibuprofen: a Presentation of Systemic Lupus Erythematosus

[Guest guest]

Case Report

Severe Systemic Hypersensitivity Reaction to Ibuprofen: a Presentation of

Systemic Lupus Erythematosus

(J Rheumatol 2006; 33:171-2)

http://www.jrheum.com/abstracts/abstracts06/171.html

STEVEN S. MOU, LYNN PUNARO, JORDI ANTÓN, and PETER M. LUCKETT

ABSTRACT.

We describe the first severe systemic hypersensitivity reaction to ibuprofen

in a pediatric patient with previously undiagnosed systemic lupus

erythematosus (SLE). An 11-year-old Thai male presented with fever, rash,

altered mental status, and hypotension after oral administration of

ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted

in recurrence of presenting symptoms. Severe hypersensitivity with

hypotension can be a rare consequence of the use of ibuprofen in children

with collagen vascular disease. When encountered in an otherwise healthy

child, a high index of suspicion must be maintained for the diagnosis of

SLE.

From the Department of Pediatrics, University of Texas Southwestern Medical

School; the Department of Pediatric Rheumatology, Texas ish Rite

Hospital, Children's Medical Center of Dallas, Dallas, Texas; and the

Hospital de Sabadell, Corporació Parc Taul, Barcelona, Spain.

S.S. Mou, MD, Department of Pediatrics, University of Texas, Southwestern

Medical School; L. Punaro, MD, Department of Pediatric Rheumatology, Texas

ish Rite Hospital, Children's Medical Center of Dallas; J. Antón, MD,

Hospital de Sabadell, Corporació Parc Taul; P.M. Luckett, MD, Department of

Pediatrics, Univ of Texas Southwestern Medical School.

Address reprint requests to Dr. P.M. Luckett, Division of Pediatric Critical

Care, Children's Medical Center, Dallas 1935 Motor Street, Dallas, Texas,

USA, 75235. E-mail: peter.luckett@...