Guest guest Posted November 28, 2006 Report Share Posted November 28, 2006 Thank you I will check into DHEA " Namaste " Tia [ ] DHEA for Lupus Hi Tia, Sorry to hear about you multiple health problems. DHEA is a master hormone that has been used successfully with Lupus. See Medline article below: : _Autoimmunity. _ (javascript: AL_get(this, 'jour', 'Autoimmunity. ') 2005 Nov;38(7):531- 40. (http://www.ncbi. nlm.nih.gov/ entrez/utils/ fref.fcgi? itool=AbstractPl us-def & PrId= 3396 & uid= 16373258 & db=pubmed & url=http: //taylorandfranc is.met apress.com/Index/ 10.1080/08916930 500285550) _Links_ (javascript: PopUpMenu2_ Set(Menu16373258 ) Effects of dehydroepiandroster one supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus. * _Nordmark G_ (http://www.ncbi. nlm.nih.gov/ entrez/query. fcgi?db=pubmed & cmd=Search & itool=pubmed_ AbstractPlus & term= " Nordmark+G " [Author]) , * _Bengtsson C_ (http://www.ncbi. nlm.nih.gov/ entrez/query. fcgi?db=pubmed & cmd=Search & itool=pubmed_ AbstractPlus & term= " Bengtsson+C " [Author]) , * _Larsson A_ (http://www.ncbi. nlm.nih.gov/ entrez/query. fcgi?db=pubmed & cmd=Search & itool=pubmed_ AbstractPlus & term= " Larsson+A " [ Author]) , * _Karlsson FA_ (http://www.ncbi. nlm.nih.gov/ entrez/query. fcgi?db=pubmed & cmd=Search & itool=pubmed_ AbstractPlus & term= " Karlsson+FA " [Author]) , * _Sturfelt G_ (http://www.ncbi. nlm.nih.gov/ entrez/query. fcgi?db=pubmed & cmd=Search & itool=pubmed_ AbstractPlus & term= " Sturfelt+G " [Author]) , * _Ronnblom L_ (http://www.ncbi. nlm.nih.gov/ entrez/query. fcgi?db=pubmed & cmd=Search & itool=pubmed_ AbstractPlus & term= " Ronnblom+L " [Author]) . Department of Medical Sciences, Section of Rheumatology, University Hospital, Uppsala, Sweden. gunnel.nordmark@ medsci.uu. se The objective of this study was to evaluate the efficacy of low dose dehydroepiandroster one (DHEA) on health-related quality of life (HRQOL) in glucocorticoid treated female patients with systemic lupus erythematosus (SLE). Forty one women ( >or= 5 mg prednisolone/ day) were included in a double-blind, randomized, placebo-controlled study for 6 months where DHEA was given at 30 mg/20 mg ( <or= 45/ >or= 46 years) daily, or placebo, followed by 6 months open DHEA treatment to all patients. HRQOL was assessed at baseline, 6 and 12 months, using four validated questionnaires and the patients' partners completed a questionnaire assessing mood and behaviour at 6 months. DHEA treatment increased serum levels of sulphated DHEA from subnormal to normal. The DHEA group improved in SF-36 " role emotional " and HSCL-56 total score (both p<0.05). During open DHEA treatment, the former placebo group improved in SF-36 " mental health " (p<0.05) with a tendency for improvement in HSCL-56 total score (p=0.10). Both groups improved in McCoy's Sex Scale during active treatment (p<0.05). DHEA replacement decreased high-density lipoprotein (HDL) cholesterol and increased insulin-like growth factor I (IGF-I) and haematocrit. There were no effects on bone density or disease activity and no serious adverse events. Side effects were mild. We conclude that low dose DHEA treatment improves HRQOL with regard to mental well-being and sexuality and can be offered to women with SLE where mental distress and/or impaired sexuality constitutes a problem. PMID: 16373258 [PubMed - indexed for MEDLINE] Display Show arnold Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2007 Report Share Posted January 21, 2007 Hi Health Activists, Last week I was at the library reading the Journal of the American Medical Association (JAMA) for January 10.1007 which had an article on the Research on the Causes and Treatments for Lupus. The full name of the disease is called Systemic Lupus Erythematosis (SLE), characterized by the immune system attacking itself for no apparent reason. Since their is plentiful funding for Genetic Research, a large portion of the research has been done on the possible genetic factors causing the disease to express itself. It seems to occur more frequently in middle aged women for some reason. The researchers seem to be perplexed and frustrated with the limitations of the current treatments which usually consist of Non-Steroidal Anti Inflammatory Drugs (NSAIDS), Immunosuppressive Drugs and Cortocosteroids. All of these have unpleasant side effects, that can be serious. Despite these dangerous side effects, very little work and even less publicity has been given to the treatment with Dehydroepiandrosterone (DHEA). DHEA is a hormone sold as a dietary supplement in the United States. It has a very safe profile in prior use, but since it is a hormone, many holistic doctors have felt that, if the patient has or is at high risk for a reproductive cancer, it might be advisable to avoid DHEA or make sure an integrative practitioner monitors the level very closely. DHEA has been very successful in the treatment of Lupus (SLE) and I accordingly wrote to JAMA citing a few of these studies. Sine I do not expect them to publish my letter I felt, it might get some attention if I sent you a copy. To The Editor: The article " Researchers Probe Lupus Causes,Treatments by Hampton appearing in the the January 10,2007 issue concentrates on the interesting developments in possible genetic causation and theoretical mechanisms, but overlooks the remarkably successful treatment using Dehydroepiandrosterone (DHEA). The author, expresses concern at the " puzzles and frustration " of those seeking diagnostic and treatment breakthroughs, but fails to acknowledge the large body of documented medical literature supporting this treatment with DHEA. Unfortunately it is only known to patients who are sophisticated enough to do their own research of the medical literature. In a double blind placebo controlled clinical trial using 200 mg of DHEA researchers found " Dehydroepiandrosterone suppresses Interleukin 10 synthesis in Women with Systemic lupus erythematosis " by Chang,DM et al., in the Ann Rheum Dis,2004,Dec;63(12):1623-6. DHEA significantly lupus flares. In another double blind placebo controlled study of " Dehydoepiandrosterone treatment of women with mild to moderate systemic lupus erythematosis: a multicenter randomized double blind, placebo controlled trial " Chang,DM et al. writing in Arthritis Rheum, 2002 Nov;46(11):2924-7 using 200 mg of DHEA found that patient global assessment of improvement in the DHEA group was statistically greater than in the placebo group.The patient having adverse flares was significantly less in the DHEA group. While these were done with mild to moderate lupus, van Vollenhoven RF.et al, conducted a " Double blind ,placebo controlled clinical trial of dehydroepiandrosterone in severe systemic lupus erythematosis " .Their results were published in Lupus,1999;8(3):169-70. In a trial of 21 patients with severe lupus, a group that received 200 mg was felt by researchers to have more severe symptoms at baseline. DHEA was given in addition to conventional treatment with corticosteroids and immunosuppressives for 6 months, followed by a 6 month open label period. 19 patients were available for evaluation at 6 months. The primary outcome was a prospectively defined responder analysis of improvement. The results showed that 7 of 9 responders in the DHEA compared to 4 of 10 patients on placebo(receiving conventional therapy). Of the secondary outcome, measuring mean improvement of SLE disease activity index (SLE-DAI) was greater in the DHEA group.(-10.3+/-3.1 vs. -3.9+/-1.4, P less than 0.07. Despite these very promising results, the author inexplicably undervalues his positive results on that the beneficial effect of DHEA and if researchers are too lazy to read the full results, they may be led to believe that DHEA is not that effective. All of these studies were done overseas, but the treatment of serious disease should not be effected by this parochialism in the age of instant communications.( Actually the last study by van Vollenhoven might have been done in the US, he is a professor at Stanford University Medical Center-AG) Arnold Gore New York,NY Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 30, 2007 Report Share Posted January 30, 2007 Hi : I have aproblemwith hair loss. I have had my thyroid, and testosterone checked and it is alwas normal. I have been lossing my hair for a long time. ( now it is showing) Any other ideas as to what I should check? I am 53 and post menopause Any info is appreciated, <mindcb45@...> wrote: Arnold, Healthy women who want to try DHEA should start with 1mg or 3mg every other day and talk to their doctors as well. They would only try it if they were having hormonal imbalances in the first place. DHEA raises the testosterone levels amoung many other things in the woman's hormonal system. Anyone who wants to try this hormone should understand where it is in a complicated chain of reactions. Pregnenolone starts the cascade of reactions. Ray Sahelian, MD's book, " Mind Boosters " has a very clear explanation of this process. The story is much different with men. I have been taking 50 mg of DHEA for more than 23 years. I do not take additional pregnenolone however. I would be very careful to add pregnenolone if you have seizures because of all the different hormonal interactions that take place. DHEA is down line from the pregnenolone and does not affect as many hormones. Also, I was taking the DHEA before my seizures returned--many years before--so I have just continued with it. Sahelian's web site has a good discussion about DHEA from many people who have tried it. Both men and women. [ ] DHEA for Lupus Hi Health Activists, Last week I was at the library reading the Journal of the American Medical Association (JAMA) for January 10.1007 which had an article on the Research on the Causes and Treatments for Lupus. The full name of the disease is called Systemic Lupus Erythematosis (SLE), characterized by the immune system attacking itself for no apparent reason. Since their is plentiful funding for Genetic Research, a large portion of the research has been done on the possible genetic factors causing the disease to express itself. It seems to occur more frequently in middle aged women for some reason. The researchers seem to be perplexed and frustrated with the limitations of the current treatments which usually consist of Non-Steroidal Anti Inflammatory Drugs (NSAIDS), Immunosuppressive Drugs and Cortocosteroids. All of these have unpleasant side effects, that can be serious. Despite these dangerous side effects, very little work and even less publicity has been given to the treatment with Dehydroepiandroster one (DHEA). DHEA is a hormone sold as a dietary supplement in the United States. It has a very safe profile in prior use, but since it is a hormone, many holistic doctors have felt that, if the patient has or is at high risk for a reproductive cancer, it might be advisable to avoid DHEA or make sure an integrative practitioner monitors the level very closely. DHEA has been very successful in the treatment of Lupus (SLE) and I accordingly wrote to JAMA citing a few of these studies. Sine I do not expect them to publish my letter I felt, it might get some attention if I sent you a copy. To The Editor: The article " Researchers Probe Lupus Causes,Treatments by Hampton appearing in the the January 10,2007 issue concentrates on the interesting developments in possible genetic causation and theoretical mechanisms, but overlooks the remarkably successful treatment using Dehydroepiandroster one (DHEA). The author, expresses concern at the " puzzles and frustration " of those seeking diagnostic and treatment breakthroughs, but fails to acknowledge the large body of documented medical literature supporting this treatment with DHEA. Unfortunately it is only known to patients who are sophisticated enough to do their own research of the medical literature. In a double blind placebo controlled clinical trial using 200 mg of DHEA researchers found " Dehydroepiandroste rone suppresses Interleukin 10 synthesis in Women with Systemic lupus erythematosis " by Chang,DM et al., in the Ann Rheum Dis,2004,Dec; 63(12):1623- 6. DHEA significantly lupus flares. In another double blind placebo controlled study of " Dehydoepiandroster one treatment of women with mild to moderate systemic lupus erythematosis: a multicenter randomized double blind, placebo controlled trial " Chang,DM et al. writing in Arthritis Rheum, 2002 Nov;46(11):2924- 7 using 200 mg of DHEA found that patient global assessment of improvement in the DHEA group was statistically greater than in the placebo group.The patient having adverse flares was significantly less in the DHEA group. While these were done with mild to moderate lupus, van Vollenhoven RF.et al, conducted a " Double blind ,placebo controlled clinical trial of dehydroepiandroster one in severe systemic lupus erythematosis " .Their results were published in Lupus,1999;8( 3):169-70. In a trial of 21 patients with severe lupus, a group that received 200 mg was felt by researchers to have more severe symptoms at baseline. DHEA was given in addition to conventional treatment with corticosteroids and immunosuppressives for 6 months, followed by a 6 month open label period. 19 patients were available for evaluation at 6 months. The primary outcome was a prospectively defined responder analysis of improvement. The results showed that 7 of 9 responders in the DHEA compared to 4 of 10 patients on placebo(receiving conventional therapy). Of the secondary outcome, measuring mean improvement of SLE disease activity index (SLE-DAI) was greater in the DHEA group.(-10.3+ /-3.1 vs. -3.9+/-1.4, P less than 0.07. Despite these very promising results, the author inexplicably undervalues his positive results on that the beneficial effect of DHEA and if researchers are too lazy to read the full results, they may be led to believe that DHEA is not that effective. All of these studies were done overseas, but the treatment of serious disease should not be effected by this parochialism in the age of instant communications. ( Actually the last study by van Vollenhoven might have been done in the US, he is a professor at Stanford University Medical Center-AG) Arnold Gore New York,NY Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 30, 2007 Report Share Posted January 30, 2007 I was loosing a lot of hair for the longest time until I did a colon cleans from www.drnatura.com the only one I found that actually worked. My hair would come out in handfuls and it hasn't done that in over 8 months now. Most tests come out normal because they haven't been updated since the 70's done off of military men. Remember toxins cause a lot in all areas of our body, if you have toxic organs you won't get the vitamins you need to have your body work right. " Namaste " Tia [ ] DHEA for Lupus Hi Health Activists, Last week I was at the library reading the Journal of the American Medical Association (JAMA) for January 10.1007 which had an article on the Research on the Causes and Treatments for Lupus. The full name of the disease is called Systemic Lupus Erythematosis (SLE), characterized by the immune system attacking itself for no apparent reason. Since their is plentiful funding for Genetic Research, a large portion of the research has been done on the possible genetic factors causing the disease to express itself. It seems to occur more frequently in middle aged women for some reason. The researchers seem to be perplexed and frustrated with the limitations of the current treatments which usually consist of Non-Steroidal Anti Inflammatory Drugs (NSAIDS), Immunosuppressive Drugs and Cortocosteroids. All of these have unpleasant side effects, that can be serious. Despite these dangerous side effects, very little work and even less publicity has been given to the treatment with Dehydroepiandroster one (DHEA). DHEA is a hormone sold as a dietary supplement in the United States. It has a very safe profile in prior use, but since it is a hormone, many holistic doctors have felt that, if the patient has or is at high risk for a reproductive cancer, it might be advisable to avoid DHEA or make sure an integrative practitioner monitors the level very closely. DHEA has been very successful in the treatment of Lupus (SLE) and I accordingly wrote to JAMA citing a few of these studies. Sine I do not expect them to publish my letter I felt, it might get some attention if I sent you a copy. To The Editor: The article " Researchers Probe Lupus Causes,Treatments by Hampton appearing in the the January 10,2007 issue concentrates on the interesting developments in possible genetic causation and theoretical mechanisms, but overlooks the remarkably successful treatment using Dehydroepiandroster one (DHEA). The author, expresses concern at the " puzzles and frustration " of those seeking diagnostic and treatment breakthroughs, but fails to acknowledge the large body of documented medical literature supporting this treatment with DHEA. Unfortunately it is only known to patients who are sophisticated enough to do their own research of the medical literature. In a double blind placebo controlled clinical trial using 200 mg of DHEA researchers found " Dehydroepiandroste rone suppresses Interleukin 10 synthesis in Women with Systemic lupus erythematosis " by Chang,DM et al., in the Ann Rheum Dis,2004,Dec; 63(12):1623- 6. DHEA significantly lupus flares. In another double blind placebo controlled study of " Dehydoepiandroster one treatment of women with mild to moderate systemic lupus erythematosis: a multicenter randomized double blind, placebo controlled trial " Chang,DM et al. writing in Arthritis Rheum, 2002 Nov;46(11):2924- 7 using 200 mg of DHEA found that patient global assessment of improvement in the DHEA group was statistically greater than in the placebo group.The patient having adverse flares was significantly less in the DHEA group. While these were done with mild to moderate lupus, van Vollenhoven RF.et al, conducted a " Double blind ,placebo controlled clinical trial of dehydroepiandroster one in severe systemic lupus erythematosis " .Their results were published in Lupus,1999;8( 3):169-70. In a trial of 21 patients with severe lupus, a group that received 200 mg was felt by researchers to have more severe symptoms at baseline. DHEA was given in addition to conventional treatment with corticosteroids and immunosuppressives for 6 months, followed by a 6 month open label period. 19 patients were available for evaluation at 6 months. The primary outcome was a prospectively defined responder analysis of improvement. The results showed that 7 of 9 responders in the DHEA compared to 4 of 10 patients on placebo(receiving conventional therapy). Of the secondary outcome, measuring mean improvement of SLE disease activity index (SLE-DAI) was greater in the DHEA group.(-10.3+ /-3.1 vs. -3.9+/-1.4, P less than 0.07. Despite these very promising results, the author inexplicably undervalues his positive results on that the beneficial effect of DHEA and if researchers are too lazy to read the full results, they may be led to believe that DHEA is not that effective. All of these studies were done overseas, but the treatment of serious disease should not be effected by this parochialism in the age of instant communications. ( Actually the last study by van Vollenhoven might have been done in the US, he is a professor at Stanford University Medical Center-AG) Arnold Gore New York,NY Quote Link to comment Share on other sites More sharing options...
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