Guest guest Posted March 14, 2005 Report Share Posted March 14, 2005 G'day, Does ANYone know ANYthing about HLA B27 ? I've signed on to do some genetic testing to further delve into Bayly's JRA, my niece's Type 1 Diabetes, and now my father's Bipolar (oh yes!) which apparently all come down through the same faulty chromosome. But I can't find any decent information about it. Does anyone know the link, or where to find out about it? Jo (Bayly, 2, extended oligo) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2005 Report Share Posted March 14, 2005 I know they tested my son for it. It is an indicator for the severity of spondylitis. My son is negative, so they do not feel he will have as many complications from it. People who are positive tend to have more problems. I am not sure where to find exact info on it, you could check the archives on the list to see if Georgina has posted info in the past. Also there is a website called www.spondylitis.org where they may have some info on it. I always assumed it was another thing like ANA or RH. Good luck, Michele ( 17, pauci & spondy) HLA B27 G'day, Does ANYone know ANYthing about HLA B27 ? I've signed on to do some genetic testing to further delve into Bayly's JRA, my niece's Type 1 Diabetes, and now my father's Bipolar (oh yes!) which apparently all come down through the same faulty chromosome. But I can't find any decent information about it. Does anyone know the link, or where to find out about it? Jo (Bayly, 2, extended oligo) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2005 Report Share Posted March 14, 2005 Jo & Grant, My daughter has tested positive for it. My knowledge is her chances of out growing JRA are slim because of this genetic factor. I unfortunately don't know anymore about it. and Allie (8poly) ________________________________ From: Tepper, Michele [mailto:MTepper@...] Sent: Monday, March 14, 2005 11:46 AM Subject: RE: HLA B27 I know they tested my son for it. It is an indicator for the severity of spondylitis. My son is negative, so they do not feel he will have as many complications from it. People who are positive tend to have more problems. I am not sure where to find exact info on it, you could check the archives on the list to see if Georgina has posted info in the past. Also there is a website called www.spondylitis.org where they may have some info on it. I always assumed it was another thing like ANA or RH. Good luck, Michele ( 17, pauci & spondy) HLA B27 G'day, Does ANYone know ANYthing about HLA B27 ? I've signed on to do some genetic testing to further delve into Bayly's JRA, my niece's Type 1 Diabetes, and now my father's Bipolar (oh yes!) which apparently all come down through the same faulty chromosome. But I can't find any decent information about it. Does anyone know the link, or where to find out about it? Jo (Bayly, 2, extended oligo) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2005 Report Share Posted March 14, 2005 My daughter tested positive for it as well. I was told that she also would have a slim chance of growing out of JRA, but also that sometimes kids that present with JRA and are HRA B27 pos. have a greater chance of developing something else later that the JRA was just a precursor for like lupus or chrones, but not always. He basically said it just makes more questions and fewer definite answers. and Hailey-2-poly Gray, Independent Educational Consultant --Usborne Books At Home (UBAH) Award-winning children's books--from Tots to Teens! --(410) 653-6339 --Join Usborne Books at Home now!----* Home Shows * Book Fairs * Direct Sales * Reading Incentive Programs * Fundraisers * Schools and Libraries * Recruiting * Booths * FUN! >From: " Ray " <leslie@...> >Reply- >< > >Subject: RE: HLA B27 >Date: Mon, 14 Mar 2005 12:59:34 -0500 > >Jo & Grant, > >My daughter has tested positive for it. My knowledge is her chances of >out growing JRA are slim because of this genetic factor. I >unfortunately don't know anymore about it. > and Allie (8poly) > > > > >________________________________ > >From: Tepper, Michele [mailto:MTepper@...] >Sent: Monday, March 14, 2005 11:46 AM > >Subject: RE: HLA B27 > > >I know they tested my son for it. It is an indicator for the severity of >spondylitis. My son is negative, so they do not feel he will have as >many complications from it. People who are positive tend to have more >problems. I am not sure where to find exact info on it, you could check >the archives on the list to see if Georgina has posted info in the past. >Also there is a website called www.spondylitis.org where they may have >some info on it. I always assumed it was another thing like ANA or RH. >Good luck, Michele ( 17, pauci & spondy) > > HLA B27 > > > >G'day, >Does ANYone know ANYthing about HLA B27 ? > >I've signed on to do some genetic testing to further delve into >Bayly's JRA, my niece's Type 1 Diabetes, and now my father's Bipolar >(oh yes!) which apparently all come down through the same faulty >chromosome. > >But I can't find any decent information about it. >Does anyone know the link, or where to find out about it? > >Jo (Bayly, 2, extended oligo) > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2005 Report Share Posted October 28, 2005 There is a strong association of HLA B27 antigen among the Spondyloarthropathies. It is usually not used alone, for diagnostic purposes, but it does help in confirming if a doctor believes someone has the symptoms of any of the spondy diseases. There is a very strong association in people who have a parent with any of the spondy diseases. All of my siblings (3) have Ankylosing spondylitis. I have 3 children with the disease and a grandchild with lower back pain who has not been tested for the antigen yet. That said, it is possible to have a spondy without this antigen present. The disease seems to be more severe and chronic in people who have the antigen. With over 100 similar arthritic conditions, misdiagnoses is common. HLA B27 association in Spondyloarthropathies. Ankylosing spondylitis 90 % Reactive arthritis (Reiter's) 40-80% Juvenile spondy 70% Enteropathic spondy 35-75% Psoriatic spondy 40-50% Undifferentiated spondy 70% Acute anterior uveitis 50% Aortic incompetence with heart block 80% http://www.annals.org/cgi/reprint/136/12/896.pdf http://www.orthop.washington.edu/uw/arthritis/tabID__3376/ItemID__130/Articles /Default.aspx http://www.spondylitis.org/about/reactive.aspx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2005 Report Share Posted October 28, 2005 Thanks Connie(Granny) When I was diagnosed by the WCB Medical Review Board, they diagnosed on the occlusion of the SI joints. They sent there report to my doctor and said it would be good if he would order the HLA b-27 and RA blood tests. Both were positive. In Medicine Hat at the time they did not have the lab facility to run the test so had to go to local hospital to have my blood taken at 6 AM and it was on the next flight out to Calgary. Just watched a program hosted by Tom Brokaw and didn't realize that he has RA. I looked at him holding his pad and noticed the hand deformity that goes with it. +Dave Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 30, 2005 Report Share Posted October 30, 2005 Connie, Your posts are so informative...I am always impressed and very grateful for your efforts. Thanks, Re: HLA B27 There is a strong association of HLA B27 antigen among the Spondyloarthropathies. Quote Link to comment Share on other sites More sharing options...
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