Re: D-Dimer Quantitative and Qualitative

[Guest guest]

Hi ,

We only get the Quantitative done. At our lab, normal is [0 - 400

ng/ml]. Then it has a note that says " negative predictive range for

pulmonary embolism and deep vein thrombosis is <500 ng/ml " .

Is your son's still like over 1000 or something like that? What has

your rheumy ever said when you questioned it?

Stacia and Hunter 8 systemic, iritis

[Guest guest]

Hi Stacia,

I went and picked up a copy of the labs that were taken last

Thursday. The lab finally did the d-dimer quantitative instead of

the qualitative. Apparently, a normal range for this is 0.54-2.09,

Christian's reading is 3.98. Obviously, this is not in the normal

range but just wondering if it is considered way high, or not. With

the qualitative test, our lab considers <500:negative,

>500:moderately positive and >1000: markedly positive. Christian has

always been in the markedly positive range. So, just trying to

figure out the meaning.

In addition, his A/G ratio is slightly elevated, normal is 0.8-2.0

and his is 2.4, any idea what this might indicate? His globulin is

2.0 and normal is 2.2-4.2. His RDW is 15.1 and normal is 11.0-15.0.

Everything else was normal and looks great.

Thanks Stacia.

> Hi ,

>

> We only get the Quantitative done. At our lab, normal is [0 - 400

> ng/ml]. Then it has a note that says " negative predictive range

for

> pulmonary embolism and deep vein thrombosis is <500 ng/ml " .

>

> Is your son's still like over 1000 or something like that? What

has

> your rheumy ever said when you questioned it?

>

> Stacia and Hunter 8 systemic, iritis

[Guest guest]

Hi ,

I looked up Robbie's labs from July for his D-Dimer results. It always says

fibrin D-Dimer & when I first asked what it was about (3 years ago) his rheumy

told me that it was one of he markers for MAS. In July, Robbie's was 0.86 and

was high - the range listed is 0.00 - 0.48 for normal. I hit the " expand " key

on the screen (his labs are drawn in the hospital where I work) and it said

this:

" Any medical condition that activates the coagulation system may elevate D-Dimer

values. This includes sepsis, thromboses, post-operative period, hemorrage,

cancer and following anti-coagulation withdrawal. In multiple studies, a

cut-off value of 1.0 ug/mL FEU (500 ng/mL D-Dimer units) had a 93-100% negative

predictive value for exclusion of venous thrombosis. To convert ug/mL to ng/mL

D-Dimer units, multiply results by 500. "

I hope this helps, a little.

Val

Rob's Mom (6,systemic)

[Guest guest]

Thanks Val,

I did the conversion and this would put Christian at a reading of

(just under) 4000. That seems very high to me. Our Rheumy has said

that the d-dimer is one of the markers for systemic JRA, but never

mentioned MAS specifically. It seems to me that since this test has

always been abnormal for Christian, that it must mean

something....but what?

What do you know about the A/G ratio?

Well, I'm not too worried because it does no good anyway! He is back

at school and loving it! All these tests can drive you insane.

Thanks

> Hi ,

> I looked up Robbie's labs from July for his D-Dimer results. It

always says fibrin D-Dimer & when I first asked what it was about (3

years ago) his rheumy told me that it was one of he markers for MAS.

In July, Robbie's was 0.86 and was high - the range listed is 0.00 -

0.48 for normal. I hit the " expand " key on the screen (his labs are

drawn in the hospital where I work) and it said this:

>

> " Any medical condition that activates the coagulation system may

elevate D-Dimer values. This includes sepsis, thromboses, post-

operative period, hemorrage, cancer and following anti-coagulation

withdrawal. In multiple studies, a cut-off value of 1.0 ug/mL FEU

(500 ng/mL D-Dimer units) had a 93-100% negative predictive value for

exclusion of venous thrombosis. To convert ug/mL to ng/mL D-Dimer

units, multiply results by 500. "

>

> I hope this helps, a little.

>

> Val

> Rob's Mom (6,systemic)

[Guest guest]

Hi ,

I really don't know what the " danger " range of a d-dimer test is,

only that is has to do with the clotting of the blood, in general

and something they look at concerning possible MAS. I know that

Hunter's d-dimer is ordered and drawn every month, but the last 3

months, the labwork results say PENDING for the d-dimer, so I don't

have any current date since it was slightly elevated around 550 or

so a few months ago. I asked out rheumy about it and he said that

unto itself, as an isolated test, it may or may not mean anything.

It is one of the many factors in determining the general health of

systemics.

As far as the RDW, Hunter's is almost always slightly above the

normal range by a few tenths or so. I don't know what the A/G ratio

is nor is it on any labwork I have. I don't see any globulin either.

I think this stuff will drive you insane if you micro-manage each

thing. I've heard many times, that any one thing that's slightly

out of whack may actually be normal for a systemic child or a

(insert your disease here) child. It's the whole picture of health

and how the child is doing that will tell the results.

Let us know what your rheumy says about the bloodwork whenever you

go next.

Hugs,

Stacia and Hunter 8 systemic, iritis

> > Hi ,

> >

> > We only get the Quantitative done. At our lab, normal is [0 -

400

> > ng/ml]. Then it has a note that says " negative predictive range

> for

> > pulmonary embolism and deep vein thrombosis is <500 ng/ml " .

> >

> > Is your son's still like over 1000 or something like that? What

> has

> > your rheumy ever said when you questioned it?

> >

> > Stacia and Hunter 8 systemic, iritis