AEDs, bone loss, and vitamin D

[Guest guest]

Osteoporosis, like other bone disorders are clearly linked now to

the use of AEDs, as explained in the abstract below. Vitamin D

supplements (not too much!) can indeed help improve calcium

absorption.

1: Epilepsy Behav. 2004 Feb;5 Suppl 2:S3-15.

Pathophysiology of bone loss in patients receiving anticonvulsant

therapy.

Fitzpatrick LA.

Division of Endocrinology, Diabetes, Metabolism, Nutrition, and

Internal

Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

fitz@...

Many studies have shown that patients taking antiepileptic drugs

(AEDs) are at

increased risk for metabolic bone disease and low bone mineral

density. Although

early reports of bone disease in patients with epilepsy often

involved

institutionalized patients, who may be at risk because of lack of

physical

activity, reduced sunlight exposure, and poor nutrition, low bone

density has

also been reported in well-nourished, ambulatory outpatients with

epilepsy.

Traditionally, attention to the problem of AED-induced bone loss has

been

focused on those drugs that induce the hepatic cytochrome P450

enzyme system,

thereby increasing the metabolism of vitamin D. However, the

mechanisms of

AED-induced bone loss appear to be multiple, and all types of AEDs

are

potentially implicated. Besides hepatic enzyme induction, mechanisms

may include

direct effects of AEDs on bone cells, resistance to parathyroid

hormone,

inhibition of calcitonin secretion, and impaired calcium absorption.

An

understanding of bone biology and the pathophysiology of bone loss

can aid in

the identification and monitoring of patients at risk and in the

planning of

appropriate prophylactic and therapeutic measures, by which most of

the

morbidity associated with AED-induced bone loss can be prevented.

PMID: 15123006 [PubMed - in process]

----------------

http://www.chclibrary.org/micromed/00070460.html

This article is more in-depth about vitamin D and describes how it

relates to seizures.

Zoe

[Guest guest]

Zoe,

Probably the real reason AED's cause osteoporosis is not calcium and Vitamin

D interference, it is because of the interuption they cause with proteins.

Osteoporosis is not, and I repeat not, due to the lack of calcium, that is a

marketing causality, it is mainly due to poor collagen matrixing with the

calcium and trace mineral abnormalities.

In health,

Mark Schauss

[ ] AEDs, bone loss, and vitamin D

> Osteoporosis, like other bone disorders are clearly linked now to

> the use of AEDs, as explained in the abstract below. Vitamin D

> supplements (not too much!) can indeed help improve calcium

> absorption.

>

> 1: Epilepsy Behav. 2004 Feb;5 Suppl 2:S3-15.

>

> Pathophysiology of bone loss in patients receiving anticonvulsant

> therapy.

>

> Fitzpatrick LA.

>

> Division of Endocrinology, Diabetes, Metabolism, Nutrition, and

> Internal

> Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

> fitz@...

>

> Many studies have shown that patients taking antiepileptic drugs

> (AEDs) are at

> increased risk for metabolic bone disease and low bone mineral

> density. Although

> early reports of bone disease in patients with epilepsy often

> involved

> institutionalized patients, who may be at risk because of lack of

> physical

> activity, reduced sunlight exposure, and poor nutrition, low bone

> density has

> also been reported in well-nourished, ambulatory outpatients with

> epilepsy.

> Traditionally, attention to the problem of AED-induced bone loss has

> been

> focused on those drugs that induce the hepatic cytochrome P450

> enzyme system,

> thereby increasing the metabolism of vitamin D. However, the

> mechanisms of

> AED-induced bone loss appear to be multiple, and all types of AEDs

> are

> potentially implicated. Besides hepatic enzyme induction, mechanisms

> may include

> direct effects of AEDs on bone cells, resistance to parathyroid

> hormone,

> inhibition of calcitonin secretion, and impaired calcium absorption.

> An

> understanding of bone biology and the pathophysiology of bone loss

> can aid in

> the identification and monitoring of patients at risk and in the

> planning of

> appropriate prophylactic and therapeutic measures, by which most of

> the

> morbidity associated with AED-induced bone loss can be prevented.

>

> PMID: 15123006 [PubMed - in process]

> ----------------

>

> http://www.chclibrary.org/micromed/00070460.html

> This article is more in-depth about vitamin D and describes how it

> relates to seizures.

>

> Zoe

>

>

>

>

>

[Guest guest]

Zoe,

My neuro also mentioned this to me. Like I said before, for some people,

AEDs can cause more problems than they're worth. Thanks for the article!

Grace

On Mon, 21 Jun 2004 03:46:49 -0000 " zoe88025 " <Zll51@...> writes:

> Osteoporosis, like other bone disorders are clearly linked now to

> the use of AEDs, as explained in the abstract below. Vitamin D

> supplements (not too much!) can indeed help improve calcium

> absorption.

>

> 1: Epilepsy Behav. 2004 Feb;5 Suppl 2:S3-15.

>

> Pathophysiology of bone loss in patients receiving anticonvulsant

> therapy.

>

> Fitzpatrick LA.

>

> Division of Endocrinology, Diabetes, Metabolism, Nutrition, and

> Internal

> Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905,

> USA.

> fitz@...

>

> Many studies have shown that patients taking antiepileptic drugs

> (AEDs) are at

> increased risk for metabolic bone disease and low bone mineral

> density. Although

> early reports of bone disease in patients with epilepsy often

> involved

> institutionalized patients, who may be at risk because of lack of

> physical

> activity, reduced sunlight exposure, and poor nutrition, low bone

> density has

> also been reported in well-nourished, ambulatory outpatients with

> epilepsy.

> Traditionally, attention to the problem of AED-induced bone loss has

>

> been

> focused on those drugs that induce the hepatic cytochrome P450

> enzyme system,

> thereby increasing the metabolism of vitamin D. However, the

> mechanisms of

> AED-induced bone loss appear to be multiple, and all types of AEDs

> are

> potentially implicated. Besides hepatic enzyme induction, mechanisms

>

> may include

> direct effects of AEDs on bone cells, resistance to parathyroid

> hormone,

> inhibition of calcitonin secretion, and impaired calcium absorption.

>

> An

> understanding of bone biology and the pathophysiology of bone loss

> can aid in

> the identification and monitoring of patients at risk and in the

> planning of

> appropriate prophylactic and therapeutic measures, by which most of

>

> the

> morbidity associated with AED-induced bone loss can be prevented.

>

> PMID: 15123006 [PubMed - in process]

> ----------------

>

> http://www.chclibrary.org/micromed/00070460.html

> This article is more in-depth about vitamin D and describes how it

> relates to seizures.

>

> Zoe

>

>

>

>