Fw: Cholesterol Drugs May Fight Inflammation, Too lot's of news in here gigi*

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Sent: Thursday, May 31, 2001 8:16 PM

Subject: Cholesterol Drugs May Fight Inflammation, Too lot's of news in here gigi*

Wednesday May 30 5:22 PM ET Cholesterol Drugs May Fight Inflammation, Too NEW YORK (Reuters Health) - If research in mice pans out, some cholesterol-lowering drugs may one day get makeovers that allow them to fight immune system-related diseases like rheumatoid arthritis.In experiments with several cholesterol drugs known as statins, investigators discovered how the medications help suppress inflammation in the body and showed that modified versions of statins can fight inflammatory disease in mice. They speculate that statin-like drugs may someday treat immune-related disorders marked by inflammation, and possibly help thwart other unwanted immune responses such as transplant rejection.Scientists at Novartis Pharma in Basel, Switzerland, and The Scripps Research Institute in La Jolla, California, report the findings in the June issue of Nature Medicine.The study was led by Dr. e Weitz-Schmidt of Novartis, a drugmaker that manufactures statin drugs.Statins are well known for their ability to lower unhealthy cholesterol levels, but research has also suggested the drugs may quiet inflammation set off by the immune system. For example, some studies of transplant recipients have suggested statins help suppress the immune response to foreign organs.In the new research, Weitz-Schmidt's team was able to uncover the possible reason statins have this ability. They found that several statins block the activity of an immune-system substance called lymphocyte function-associated antigen-1 (LFA-1). LFA-1 dwells on the surface of certain immune cells and helps orchestrate the body's inflammatory response.Moreover, when the scientists modified the statins to create an even stronger bond to LFA-1, the resulting compound suppressed abdominal inflammation in mice.These effects against inflammation are unrelated to the drugs' ability to lower cholesterol, the researchers note. Instead, by binding with it, certain statin compounds appear to block LFA-1.``This finding,'' the investigators write, ``indicates that statins might be able to interfere with anti-inflammatory processes and the immune response.''In the future, they speculate, compounds derived from statins might treat autoimmune diseases such as rheumatoid arthritis and psoriasis, or be useful in tissue transplants.SOURCE: Nature Medicine 2001;7:687-692. I have un expected company from out of town, they arrived about and hour ago, please pass this on to your friends if you believe they would be interested in reading this article. I'll try to surf the news later this evening, in case I don't have a chance, we have some fantastic women who can surf like pros too. I'll try to find the hard ones later! Hugs this is one of my favorite sites..get ready to smile ok! * Oops we all need to read this one, and pass it around to our friends, and family members too. Toxic Shock Syndrome Toxic Shock Syndrome You've probably heard about this disease before. But how much do you really know about it? Who can get it? How would you recognize it? And what should you do if you or anyone thought they had it? TSS is a rare disease but because it is potentially serious, it's important to know about it and what action to take if you think you have the symptoms. http://tampax.com/tss.html I've decided to send you ton's of articles I've found, that we need to all read, where we're all sharing equally with each other. Here they come, just cut and paste them in at the top..Wa La magic..* God bless each of you...now lets have some fun! gigi Here is a story that you'll all be interested in reading ABCNEWS.com : Company to Pay $40M in PCB Suit , an one of our breast implant attorneys represented & won for these people yea! http://more.abcnews.go.com/sections/us/dailynews/pcbsettlement010424.html Bacteria Hide in Urine After Antibiotic Treatment http://dailynews./h/nm/20010529/hl/urine_1.html ABCNEWS.com : CDC Sees Increase of Pool-Borne Illness CNN Programs - Larry King Live this can effect your immune systems... http://abcnews.go.com/sections/living/DailyNews/swimming_germs010525.html Bacteria May Swap Drug-Resistance Gene http:// etc.