Fw: Hi Kathy!

[Guest guest]

Hi Kathy!

This was posted on autism treatment. Knew you'd find it interesting.

Have a great new year!!!

Becky Simpson

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Abstract Mercury in both organic and inorganic forms is neurotoxic. Methylmercury (MeHg) is a commonly encountered form of mercury in the environment. Early electrophysiological experiments revealed that MeHg potently affects the release of neurotransmitter from presynaptic nerve terminals. Recently, the hypothesis that these alterations may be mediated by changes in the intracellular concentration of Ca2+ has been supported. MeHg alters Ca2+ by at least 2 mechanisms. First, it disrupts regulation of Ca2+ from an intracellular Ca2+ pool and second, it increases the permeability of the plasma membrane to Ca2+. MeHg also blocks plasma membrane voltage-dependent Ca2+ and Na+ channels in addition to activating a nonspecific transmembrane cation conductance. Chronic MeHg exposure results in ultrastructural changes and accumulation of MeHg within mitochondria. In vitro, MeHg inhibits several mitochondrial enzymes and depolarizes the mitochondria membrane subsequently reducing ATP production and Ca2+ buffering capacity. Inhibition of protein synthesis is observed after in vivo or in vitro exposures of MeHg and may be an early effect of MeHg. Thus, the early cellular effects of exposure to MeHg are diverse and cell damage likely occurs by more than one mechanism, the effects of which may be additive or synergistic.Atchison, W.D., Hare, M.F.: Mechanisms of methylmercury-induced neurotoxicity. FASEB Journal 8:622-629; 1994 Here is some information from the article: " MeHg accumulates in the brain and becomes associated with motochondria, endoplasmic reticulum, golgi complex, nuclear envelopes an lisosomes. In nerve fibers, MeHg is localized primarily in myelin sheaths and mitochondria. " ... " Studies of MeHg neurotoxicity have traditionally involved behavioral or pathological observations in animals treated for days or weeks with MeHg, or observations of acute or semiacute effects of MeHg primarily using in vitro systems. There have been few mechanistic studies using animals treated chronically with MeHg. " " Toxicity with MeHg probably does not result from action on a single target. Instead, because of it's highly reactive nature, a complex series of many unrelated effects may occur more or less simultaneously, initiating a sequence of additional events that may ultimately lead to cell death. "