Re: naproxyn and kidney infections

[Guest guest]

Hi Kasey,

It might very well be realted. I wish I could be of more help but this hasn't been a problem for us. My son has been taking Indomethacin for 6 years. He took Naproxen for a couple months before we switched over. He tolerates indomethacin well, takes cytotec with each dose to help prevent gastric problems. He hasn't had any kidney problems. Maybe others whose children take naproxen, or those who have had kidney infection problems, will be able to share their experiences. That will help you better. I have read that Celecoxib, one of the newer meds, causes less renal side effects than the traditional NSAIDs.

Take Care,

Georgina

CELECOXIB

Hi there,My daughter has juvenile rheumatoid arthritis (JRA) and has been onnaproxyn for about 8 months. She has gotten two kidney infections inrecent months, and we are wondering if the naproxyn might be part ofthe problem. We are pursuing other clues as well, but wondering ifanyone knows of naproxyn or NSAIDs in general having anything to dowith kidney infections. I know that long term they can damage thekidneys but that wouldn't explain infection, except that maybe thekidneys are weakened when some bug comes along.thanks for your help,Kasey

[Guest guest]

Hi

My daughter, Meg , has been on Naprosyn for almost 5 yrs. She now takes 500

mg in a.m. and 375mg at night. We have been lucky that all kidney function

tests have remained ok. She has had no kidney infections over this time of

being on the medicine. She is 12 now. Don't know the dosage your child is

on, it may be dose dependant???? or perhaps in combination with other drugs

if she is on anything else.

Or maybe not related to medication at all. It sure is frustrating and time

consuming trying to figure these things out. Have a Happy Holiday.

Deb Swaney (mom to Meg 12 y.o pauci)

[Guest guest]

Just a story about Naprosyn from my childhood. My mother had polio before I was born (1955 I believe). She developed severe osteoarthritis as pre post-polio syndrome. In the early 70's before naprosyn had FDA approval in the US, it was available in Mexico. Since we lived on the Mexican border, it was easy to obtain. Her doctor prescribed it, and she took it for years. I am not sure of the dose or the actual length of time (10 years?) that she took it, but it was hailed as a miracle drug for her. The down side was that when it stopped working, it had so messed up her system, she could take nothing else. She develops allergic reactions to everything she tries to take...mouth sores, diarreah (sp), dizziness, severe rash. She has tried all the new drugs such as celebrex and vioxx, but it is always the same.

Please understand that my intent is not to bring a negative attitude into a positive picture, but to maybe raise questions for you to ask your rheumy. I hope that her case was an exception to the rule, but as our intent here is to help educate with our own experience, here's a little more food for thought.

I hope that everyone can have as pain free Christmas season as possible, and may we remember the reason for the celebration.

Christy

[Guest guest]

Kasey,

Hi, My daughter has had JRA(systemic) since she was 5,

she is now almost 10. She is off all medications right now except

methotrexate and folic acid. She was on Indocin for many years.

The reason I am responding to your letter is just got

over a really bad kidney infection. She came home from school 2 weeks

ago and said she ached all over and felt hot. She had a very high

fever by the evening time and pointed to her kidneys saying that is

where it hurt the most.At first I thought it was the Arthritis coming

back, but it wasnt. I rememeber her complaining her bladder hurt her

a few days before this.

I took her to the doctor the next morning and he said it was pretty

bad, she got a shot of antibiotics in his office and started on more

the next day. After 3 day she still wasnt better. Up all night with

fevers and getting sick. I took her back and she got another shot. It

took a week for her to feel better. It really reminded me of just how

terrible this JRA is and brought back all the memories of how sick

she was. This only lasted a week, but the JRA fevers lasted for

months.

Her last 2 bad flares both started in January, after having a

virus or the flu in December. I am very worried now that this kidney

infection could bring the JRA out again. Has any one had this happen

to them?

Sorry to go off the subject, has your daughter had many UTIs? Mine

has had so many since she was a baby I cant count them. Though this

is the first one in about 2 years.Wish I could answer your

question,maybe someone else can help us out with the connection

between the two. Have a good holiday

> Hi there,

>

> My daughter has juvenile rheumatoid arthritis (JRA) and has been on

> naproxyn for about 8 months. She has gotten two kidney infections

in

> recent months, and we are wondering if the naproxyn might be part of

> the problem. We are pursuing other clues as well, but wondering if

> anyone knows of naproxyn or NSAIDs in general having anything to do

> with kidney infections. I know that long term they can damage the

> kidneys but that wouldn't explain infection, except that maybe the

> kidneys are weakened when some bug comes along.

>

> thanks for your help,

> Kasey

[Guest guest]

Kasey,

This is so interesting. How old is your child? My daughter is 4 ½. She has had 2 urinary tract infections this past month. After the first, the pediatrician wanted to give her a voiding cysto urethral gram (VCUG) where they go up with a catheter to see if your child has kidney reflux and the urine is flowing backwards up the ureters to kidney from the bladder. I refused it b/c I thought it was invasive and excessive after one UTI so the pediatrician agreed to just watch her and take in urine samples over the next 3 months. Well, she now has another UTI so I have this test scheduled for Jan 10th. I am dreading it b/c poor Nikki has been through so much with the arthritis. They just hold her down to put this catheter in her which is going to be awful. Nikki has been on Naprosyn for 11 months now and is also on Methotrexate. I asked the rheumatologist if she had other patients getting repeated UTIs and she said no. I asked her if the Methotrexate could be causing this and she said that it does suppress your immune system but she would think Nikki would be getting colds, etc. and she is not. She said maybe it is suppressing her immune system enough that the UTIs are now showing up and Nikki has always had this problem with kidney reflux but was able to fight it off before. I did not ask about the Naprosyn at all but I will. Is your child scheduled for a VCUG? What is your pediatrician recommending after 2 UTIs. I know if you are under age 3 and get a UTI, they automatically make you have the VCUG but since Nikki was older, I just thought she could not have kidney reflux b/c it would have shown up earlier.

Please keep me posted on news with your child.

Thanks

Chris

naproxyn and kidney infections

Hi there,

My daughter has juvenile rheumatoid arthritis (JRA) and has been on

naproxyn for about 8 months. She has gotten two kidney infections in

recent months, and we are wondering if the naproxyn might be part of

the problem. We are pursuing other clues as well, but wondering if

anyone knows of naproxyn or NSAIDs in general having anything to do

with kidney infections. I know that long term they can damage the

kidneys but that wouldn't explain infection, except that maybe the

kidneys are weakened when some bug comes along.

thanks for your help,

Kasey

[Guest guest]

I know you originally wrote this to someone else, but I hope this helps.

My daughter, who is now 5, had Bilateral Ureteral Reflux Grade 3. She has lost 25% of the usage of her right kidney because of it and we had it surgically corrected when she was 18 months old. She has had 3 VCUG's, and all kinds of other kidney/bladder tests and so, so many catheters that it's hard to count.

It is very uncomfortable for them, but if you get a good nurse and ask them to make it as comfortable as possible (especially using creams and things that are available to help ease the discomfort) it is bearable.

Kelli's last procedure (except that we may be undergoing more next week) was in February and she was also 4-1/2 years old. I just explained to her as we were getting ready that she needed to hold real still and they were going to put a tiny straw (catheter) where she goes potty and take out some "pee-pee". It didn't take away the discomfort, but it helped her understand what they were doing. She only cried a little and then asked me if I was still proud of her because she had to cry. It made me cry (and of course I was so proud of her).

Anyway, it is a scary thing to have to go through for both of you, but very much worth it if she does have problems such as these. Kelli's was bad enough that the surgeon said she would never outgrow it, and in a short 18 months of life, it was wreaking much havoc on her kidneys. So, remember all this as you are going through it.

Hope this helps.

Angie

[Guest guest]

This is her second kidney infection; the first one landed her in the

hospital for 2 days, this one didn't thank goodness. She has had a

few UTI's but we're so hypersensitive to the signs now that we think

it's unlikely that she got this kidney infection as an escalation of

a UTI. Possibly reflux and we are going to have the VCUG done in

next 3 weeks or so... not looking forward to that, how can it not be

traumatic? We'll do our best w/it.

Anyway, that's why we're wondering if the naprosyn could have any

relationship, or if it's just a weak immune system and something

else. Also trying to learn about how a family penchant for

hypothyroidism might play into this... we will get her thyroid

tested next time she gets a blood test.

Thanks for your note and others. It's nice to connect with this

community of people who understand and can help with information and

camaraderie.

Kasey

> > Hi there,

> >

> > My daughter has juvenile rheumatoid arthritis (JRA) and has been

on

> > naproxyn for about 8 months. She has gotten two kidney

infections

> in

> > recent months, and we are wondering if the naproxyn might be

part of

> > the problem. We are pursuing other clues as well, but wondering

if

> > anyone knows of naproxyn or NSAIDs in general having anything to

do

> > with kidney infections. I know that long term they can damage

the

> > kidneys but that wouldn't explain infection, except that maybe

the

> > kidneys are weakened when some bug comes along.

> >

> > thanks for your help,

> > Kasey

[Guest guest]

Hi

is nearly 4. We were getting recommendation & pressure from

ped. to do the VCUG and have held off for the same reasons (after 2

UTI's) since we thought possibly baths in deep bathtub or not

drinking enough water might have caused it. But now with 2 kidney

infections, neither of which seemed to start with a UTI we are

definitely doing the VCUG w/in next 3 weeks.

We should definitely keep in touch since our kids are about same age

and are have similar problems right now.

Kasey

> Kasey,

>

> This is so interesting. How old is your child? My daughter is 4

½. She

> has had 2 urinary tract infections this past month. After the

first, the

> pediatrician wanted to give her a voiding cysto urethral gram

(VCUG) where

> they go up with a catheter to see if your child has kidney reflux

and the

> urine is flowing backwards up the ureters to kidney from the

bladder. I

> refused it b/c I thought it was invasive and excessive after one

UTI so the

> pediatrician agreed to just watch her and take in urine samples

over the

> next 3 months. Well, she now has another UTI so I have this test

scheduled

> for Jan 10th. I am dreading it b/c poor Nikki has been through so

much with

> the arthritis. They just hold her down to put this catheter in

her which is

> going to be awful. Nikki has been on Naprosyn for 11 months now

and is also

> on Methotrexate. I asked the rheumatologist if she had other

patients

> getting repeated UTIs and she said no. I asked her if the

Methotrexate

> could be causing this and she said that it does suppress your

immune system

> but she would think Nikki would be getting colds, etc. and she is

not. She

> said maybe it is suppressing her immune system enough that the

UTIs are now

> showing up and Nikki has always had this problem with kidney

reflux but was

> able to fight it off before. I did not ask about the Naprosyn at

all but I

> will. Is your child scheduled for a VCUG? What is your

pediatrician

> recommending after 2 UTIs. I know if you are under age 3 and get

a UTI,

> they automatically make you have the VCUG but since Nikki was

older, I just

> thought she could not have kidney reflux b/c it would have shown

up earlier.

>

> Please keep me posted on news with your child.

>

> Thanks

> Chris

>

> naproxyn and kidney infections

>

> Hi there,

>

> My daughter has juvenile rheumatoid arthritis (JRA)

and has

> been on

> naproxyn for about 8 months. She has gotten two

kidney

> infections in

> recent months, and we are wondering if the naproxyn

might be

> part of

> the problem. We are pursuing other clues as well,

but

> wondering if

> anyone knows of naproxyn or NSAIDs in general having

> anything to do

> with kidney infections. I know that long term they

can

> damage the

> kidneys but that wouldn't explain infection, except

that

> maybe the

> kidneys are weakened when some bug comes along.

>

> thanks for your help,

> Kasey

[Guest guest]

Hi Kasey,

I'm glad that others have written in to share their experiences. I hope you can get some answers soon, to avoid this becoming a worsening problem for your daughter. I hope the results from the VCUG lead the doctors in the right direction towards solving this. I do hope it goes smoothely and isn't highly traumatic. Please remind us before goes in, so we can keep her in our thoughts as the date for the procedure nears.

Take Care,

Georgina

This is her second kidney infection; the first one landed her in the hospital for 2 days, this one didn't thank goodness. She has had a few UTI's but we're so hypersensitive to the signs now that we think it's unlikely that she got this kidney infection as an escalation of a UTI. Possibly reflux and we are going to have the VCUG done in next 3 weeks or so... not looking forward to that, how can it not be traumatic? We'll do our best w/it.Anyway, that's why we're wondering if the naprosyn could have any relationship, or if it's just a weak immune system and something else. Also trying to learn about how a family penchant for hypothyroidism might play into this... we will get her thyroid tested next time she gets a blood test.Thanks for your note and others. It's nice to connect with this community of people who understand and can help with information and camaraderie.Kasey

[Guest guest]

and Kasey, I just had to respond here because even though I'm a jra Vet I will tell you that I am so prone to UTI's that I too go to the doctor (internist ) at least once a month if not sooner for urinalysis. I am not likely to have a cold ..bet I haven't had five in my 40 years but I have no symptoms for a UTI until it's in the bladder or even to the kidney. So supressing the immune system is just that suppressing the whole enchilada... most people get the colds and anything their exposed too but I've always been the one that does things the perplexing way :) Is it due to long term use of nsaid's ? not sure ... Is it long term use of pred. ? got me.... Is it Dmards ??? no way to tell ...what ever it's always in the back of my mind and I use every precaution, special wipes, a gallon or more of water a day, cranberry juice, no salt, no caffeine, constant testing. I actually think it's just one more function being played with by the JRA I'm not sure about your rhummy but the one I used to go to did not check for UTI's in the urinalysis . So when I ask how was my urine test he said fine ...as he was no looking for bacteria , he was testing for other things. A UTI left untreated can go from Urinary tract , to bladder , to kidney, to blood stream pretty quickly. naproxyn and kidney infections Hi there, My daughter has juvenile rheumatoid arthritis (JRA) and has been on naproxyn for about 8 months. She has gotten two kidney infections in recent months, and we are wondering if the naproxyn might be part of the problem. We are pursuing other clues as well, but wondering if anyone knows of naproxyn or NSAIDs in general having anything to do with kidney infections. I know that long term they can damage the kidneys but that wouldn't explain infection, except that maybe the kidneys are weakened when some bug comes along. thanks for your help, Kasey

[Guest guest]

Kasey,

I was glad to hear does not have kidney reflux. Nikki has her VCUG this Thursday. Can you explain what they did for the test? You said the hard part was having your daughter urinate. I thought with the catheter in, she would automatically urinate. What exactly transpired for this test. I am not looking forward to it at all. Did they let you go in for the test?

Thanks

Chris

naproxyn and kidney infections

>

> Hi there,

>

> My daughter has juvenile rheumatoid arthritis (JRA)

and has

> been on

> naproxyn for about 8 months. She has gotten two

kidney

> infections in

> recent months, and we are wondering if the naproxyn

might be

> part of

> the problem. We are pursuing other clues as well,

but

> wondering if

> anyone knows of naproxyn or NSAIDs in general having

> anything to do

> with kidney infections. I know that long term they

can

> damage the

> kidneys but that wouldn't explain infection, except

that

> maybe the

> kidneys are weakened when some bug comes along.

>

> thanks for your help,

> Kasey

[Guest guest]

Hi

I was just wondering how Nikki's VCUG was? Did you get to go in with her, while they were doing the actual procedure? I hope evrything went well and that it wasn't too traumatic or painful. I hope the results were alright.

Aloha,

Georgina

Kasey, I was glad to hear does not have kidney reflux. Nikki has her VCUG this Thursday. Can you explain what they did for the test? You said the hard part was having your daughter urinate. I thought with the catheter in, she would automatically urinate. What exactly transpired for this test. I am not looking forward to it at all. Did they let you go in for the test?

Thanks, Chris

[Guest guest]

Chris-

Poor Nikki!! I did have to chuckle at her comments. That sounds so much

like how would react. I'm glad everything was " normal. " Congrats on

your pregnancy:)!

Diane (, 2, pauci)

[Guest guest]

Dear I know that test was awful and I hope that you & Nikki can wipe it from your memory. I remember you telling us about this test being scheduled but I don't remember if you said that Nikki had also had her throid checked for underactivity. If not , you may ask your doc . about it because I too had and still have UTI's and it was one of my first signs of hypothyroidism. Good Luck :):)Tree:):):) RE: naproxyn and kidney infections Georgina, Nikki had the VCUG test and it was normal which was good news. The test itself was awful. They would not let me go in because I am pregnant so my husband went in. Nikki was screaming for 10 minutes saying "I do not like you. You are bad". I just felt so bad for her and all the JRA kids for all they have been put through. We just continue to monitor and have Nikki's urine checked periodically. Thanks for your support, -----Original Message-----From: Georgina [mailto:gmckin@...]Sent: Wednesday, January 16, 2002 2:56 PM Subject: Re: naproxyn and kidney infections Hi I was just wondering how Nikki's VCUG was? Did you get to go in with her, while they were doing the actual procedure? I hope evrything went well and that it wasn't too traumatic or painful. I hope the results were alright. Aloha, Georgina Kasey, I was glad to hear does not have kidney reflux. Nikki has her VCUG this Thursday. Can you explain what they did for the test? You said the hard part was having your daughter urinate. I thought with the catheter in, she would automatically urinate. What exactly transpired for this test. I am not looking forward to it at all. Did they let you go in for the test? Thanks,