Association Between Toxic Shcok Syndrome & JRA ?

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Monatsschrift Kinderheilkunde

Abstract Volume 146 Issue 2 (1998) pp 117-120

Zweimaliges toxisches Schocksyndrom Superantigene als gemeinsamer

Nenner?

Recurrent toxic shock syndrome in a patient with juvenile rheumatoid

arthritis - speculation on a common superantigen pathogenesis

C. Balmer, B. Stastny, H. Hochreutener, C. Kind, K. Baerlocher

Ostschweizerisches Kinderspital, St. Gallen

Summary A sixteen year old girl with juvenile rheumatoid arthritis

suffered two episodes of toxic shock syndrome within a short period of

time. Both occasions were associated with menstruation. Mycoplasma

hominis was isolated in the tracheal secretions once.

Discussion: The etiology of the toxic shock syndrome has been

extensively described. The toxic shock syndrome toxin-1 acts as a

superantigen in toxic shock syndrome and interestingly a similar

mechanism is discussed in juvenile rheumatoid arthritis. This case

report demonstrates the possibility of a close relationship between

toxic shock syndrome and juvenile rheumatoid arthritis and raises the

suspicion of a similar immunopathogenetic process.

Schlüsselwörter Toxisches Schocksyndrom · Juvenile chronische Arthritis

· Superantigen · Mycoplasma hominis