Devanee, pregnancy

[Guest guest]

Dear Devanee,

I have had AIH when beeing pregnant with my second child, he was born in 2001.

At that time the recommendation here in Germany was to stay on a low dose of

prednisone and not to

take Imuran druing pregnancy.

I took 5 mg and had a mild flare up in week 25 or so. Increased the prednisone

and got gestational diabetes (the reason was the prednisone plus overweight).

Apart from that I got into remission during pregnancy with a final dose of 10 mg

prednisone. Another flare up came 1 year later beeing on 5 mg prednisone alone.

I was breast feeding and could not take Imuran for that reason.

Some have the opinion that the hormones during breast feeding trigger an

aggravation of autoimmune disease. I don't know.

Stopping both and waiting to become pregnant is probably too risky. The positive

effect of pregnany on autoimmune disease is not a sudden reaction but one that

develops with time (maybe parallel to hormone levels). You could run too easy

into a flare up. Lower or medium prednisolone doses are safe in pregnancy, at

least this is well known.

The other question: when reducing prednisone I always had pain in the joints for

quite some time and for some days I was feeling like a battery with no charge at

all.

Hope I could help you,

regards and all the best,

> Hi! I am new to this forum and new to the AIH disease. I was dx 2

> months ago and am in the learning process. I am currently on 100

mg

> of Imuran and 5 mg of prednisone. I have seen 2 doctors with

respect

> to this diagnosis. I would like to have another child sooner than

> later if possible (I have 2 healthy children already). One doctor

> says she would like to see my levels normal for 3-4 months and then

> take me off the meds completely and then get pregnant. The other

> doctor wants me to get down to 75 mg of Imuran and no prednisone

and

> stay on the Imuran while I am pregnant. He says recent studies

show

> there is no increased risk of birth defects to the baby because of

> Imuran. Has anyone been on Imuran while pregnant or does anyone

know

> of any studies on pregnancy and Imuran? Or has anyone discussed it

> with their doctor? If so, what do they say?

>

> I've also seen a few people mention side-effects while decreasing

or

> getting off prednisone completely. What kind of side-effects?

>

> Thank you for any help in advance!

>

> Devanee

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