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Fw: Silicone-Injected Mice Produce More Immune Proteins

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From: " ilena rose " <ilena@...>

Sent: Sunday, May 06, 2001 12:08 PM

Subject: Silicone-Injected Mice Produce More Immune Proteins

> ~~~ thanks chris and myrl ~~~

>

> Silicone-Injected Mice Produce More Immune Proteins

>

> Mice exposed to silicone oils or gels develop immune-system

> abnormalities, according to researchers from Rochester General Hospital

> and the University of Florida.

>

> They report their findings in the May issue of the journal Clinical and

> Diagnostic Laboratory Immunology.

>

> " Although most published epidemiological studies have found little

> evidence of systemic autoimmune disease associated with silicone breast

> implants, there still remains a question of whether silicones can cause

> local and/or systemic immune dysfunction, " the researchers say.

>

> To answer this question, the researchers injected mice with silicone gel

> and silicone oil to see what would happen.

>

> Compared to control mice, the silicone-injected mice produced

> significantly more of certain immune system proteins in a pattern

> similar to experimentally produced lupus in mice.

>

> It is important to note, however, that silicone did not induce the

> development of autoantibodies.

>

> " These observations may be relevant to understanding the vague and often

> poorly defined autoimmune-like phenomena occurring in certain

> individuals with silicone implants, " say the researchers. " However,

> further experimental and clinical studies will be necessary to address

> this question. "

>

> (J.O. Naim, M. Satoh, N.A. Buehner, K.M.L. Ippolito, H. Yoshida, D.

> Nusz, L. Kurtelawicz, S.F. Cramer, and W.H. Reeves. 2000. Induction of

> hypergammaglobulinemia and macrophage activation by silicone gels and

> oils in female A.SW mice. Clinical and Diagnostic Laboratory Immunology,

> 7: 366-370.)

>

>

> 23-May-2000

>

>

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