Guest guest Posted February 8, 2006 Report Share Posted February 8, 2006 It sure sounds like a classic prolactinoma in the pituitary. It's curious that it doesn't show up on imaging, but I'm wondering if it can be a microadenoma or there is a problem with her hypothalamus and it's production of Dopamine. Dopamine is really the only thing that inhibits prolactin. Prolactin doesn't have a stimulating hormone. Sorry, you probably already know all this. But, it's all I can think at this point. AmyOn Feb 8, 2006, at 6:57 PM, Haywood wrote: ok this case has me stumped... 36 year old woman, with high prolactin levels, averaging about 100 points. She is NOT trying to conceive. She would like to address the high Prolactin without western meds, if possible. i do not have her lab work she has to get copies, this is what she knows... she did western blood work and salivary panels. Most everything has come back normal except for: Elevated prolactin Borderline low DHEA Low free T3 Symptoms: amenorrhea, lactation, acne, severe mood swings Diet: vegan x 10 years What is the mechanism causing this? She has had imaging and does not have any masses excreting prolactin. Thanks everyone! - Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 10, 2006 Report Share Posted February 10, 2006 Hello , The problem looks like it is in her thyroid and adrenals. People with primary hypothyroidism usually have hyperprolactinemia. The reason is that TRH also stimulates prolactin release from the pituitary. Since her T3 is low (due to inadequate conversion of T4 to T3), the body assumes low thyroid function causing TRH release which then causes prolactin release. It is actually quite common but we often miss this because we don't measure prolactin routinely. Also her low T3 could be caused by chronic high cortisol because cortisol/stress inhibits the T4 to T3 conversion. The hyperprolactinemia is then causing her other symptoms eg. amenorrhea etc... What was her salivary cortisol levels? (was it out of phase) What was her TSH? (high normal) You can try any dopamine agonist to bring down the hyperprolactinemia. Or phosphatidylserine to stop the TRH stimulation. Treat the adrenals and the thyroid function (T4 to T3: selenium). Reduce stress if possible. Johan Ghazali ND Vancouver, BC ok this case has me stumped... 36 year old woman, with high prolactin levels, averaging about 100 points. She is NOT trying to conceive. She would like to address the high Prolactin without western meds, if possible. i do not have her lab work she has to get copies, this is what she knows... she did western blood work and salivary panels. Most everything has come back normal except for: Elevated prolactin Borderline low DHEA Low free T3 Symptoms: amenorrhea, lactation, acne, severe mood swings Diet: vegan x 10 years What is the mechanism causing this? She has had imaging and does not have any masses excreting prolactin. Thanks everyone! - __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 13, 2006 Report Share Posted February 13, 2006 Hi Johan, What are the dopamine agonists you use? Dr. Gill, ND, Rossland, BC. Re: High prolactin Hello ,The problem looks like it is in her thyroid andadrenals. People with primary hypothyroidism usuallyhave hyperprolactinemia. The reason is that TRH alsostimulates prolactin release from the pituitary. Sinceher T3 is low (due to inadequate conversion of T4 toT3), the body assumes low thyroid function causing TRHrelease which then causes prolactin release. It isactually quite common but we often miss this becausewe don't measure prolactin routinely. Also her low T3could be caused by chronic high cortisol becausecortisol/stress inhibits the T4 to T3 conversion.The hyperprolactinemia is then causing her othersymptoms eg. amenorrhea etc...What was her salivary cortisol levels? (was it out ofphase)What was her TSH? (high normal)You can try any dopamine agonist to bring down thehyperprolactinemia.Or phosphatidylserine to stop the TRH stimulation.Treat the adrenals and the thyroid function (T4 to T3:selenium). Reduce stress if possible.Johan Ghazali NDVancouver, BCok this case has me stumped...36 year old woman, with high prolactin levels,averaging about100 points. She is NOT trying to conceive. She wouldlike to address thehigh Prolactin without western meds, if possible.i do not have her lab work she has to get copies, thisis what she knows...she did western blood work and salivary panels.Most everything has come back normal except for:Elevated prolactinBorderline low DHEALow free T3Symptoms: amenorrhea, lactation, acne, severe moodswingsDiet: vegan x 10 yearsWhat is the mechanism causing this? She has hadimaging and does not have any masses excreting prolactin.Thanks everyone!-__________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 13, 2006 Report Share Posted February 13, 2006 Hi Johan, What are the dopamine agonists you use? Dr. Gill, ND, Rossland, BC. Re: High prolactin Hello ,The problem looks like it is in her thyroid andadrenals. People with primary hypothyroidism usuallyhave hyperprolactinemia. The reason is that TRH alsostimulates prolactin release from the pituitary. Sinceher T3 is low (due to inadequate conversion of T4 toT3), the body assumes low thyroid function causing TRHrelease which then causes prolactin release. It isactually quite common but we often miss this becausewe don't measure prolactin routinely. Also her low T3could be caused by chronic high cortisol becausecortisol/stress inhibits the T4 to T3 conversion.The hyperprolactinemia is then causing her othersymptoms eg. amenorrhea etc...What was her salivary cortisol levels? (was it out ofphase)What was her TSH? (high normal)You can try any dopamine agonist to bring down thehyperprolactinemia.Or phosphatidylserine to stop the TRH stimulation.Treat the adrenals and the thyroid function (T4 to T3:selenium). Reduce stress if possible.Johan Ghazali NDVancouver, BCok this case has me stumped...36 year old woman, with high prolactin levels,averaging about100 points. She is NOT trying to conceive. She wouldlike to address thehigh Prolactin without western meds, if possible.i do not have her lab work she has to get copies, thisis what she knows...she did western blood work and salivary panels.Most everything has come back normal except for:Elevated prolactinBorderline low DHEALow free T3Symptoms: amenorrhea, lactation, acne, severe moodswingsDiet: vegan x 10 yearsWhat is the mechanism causing this? She has hadimaging and does not have any masses excreting prolactin.Thanks everyone!-__________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 9, 2006 Report Share Posted November 9, 2006 Hi everyone I had a question about prolctin levels. I recently over the years have had prolactin tested regularily and then all of a sudden it has come back high. I know this can mean I have a prolactinoma. I was wandering can HIGH ESTRADIOL levels cause prolactin to spike ? I think I had read that once here before and just wanted to get an answer if anyone has had a similar experience. I had MRi done and it came back negative as to any lesions or tumors. Just trying to make sense of it all Manraj Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.