A SAFE HEAVY METAL CHELATOR

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Explore! Volume 14, Number 4, 2005

Introduction

It would be true to say that nearly everyone on the globe today

has some degree of heavy metal toxicity – from air pollution,

inoculations,

fish, water contamination, amalgam fillings, in-utero

exposure from mother's fillings, and toxins. The World Health

Organization (WHO) has acknowledged environmental pollution

as the underlying cause of 80% of all chronic degenerative

diseases.1 In a Technical report on mercury in the environment

by the Committee on Environmental Health2 it was written

that " the developing fetus and young children are thought to be

disproportionately affected by mercury exposure, because many

aspects of development, particularly brain maturation, can be

disturbed by the presence of mercury. Minimizing mercury

exposure is, therefore, essential to optimal child health. "

Heavy or toxic metals are trace metals that are at least five

times denser than water. As such, they are stable elements in that

they cannot be metabolised by the body, as well as bio-accumulative

in that they are passed up the food chain to humans.

A Technical Report written by the American Academy of

Pediatrics also wrote: " Mercury in all of its forms is toxic to

the fetus and children, and efforts should be made to reduce

exposure to the extent possible to pregnant women and children

as well as the general population. " 3

There are at least 76 published functional and behavioural

abnormalities associated with heavy metal toxicity.4

The measurement of heavy metals from the body can now

be undertaken with a detection limit that exceeds parts per

billion using mass spectrometers. Since we can only measure

what the patient can eliminate, not the actual total body

burden, it is important to measure what is eliminated

in both the urine and the faeces in order to have a more

representative picture as different chelating agents prefer

different elimination pathways. If only urine or only faeces

are used, then it is easy to miss the chelating effects of a new

compound being tested. In these series of trials, both urine

and faeces were used for testing.

Abstract

Of late, a three-year heavy metal detoxification study

was concluded in a Russian metal foundry. The work was

commissioned by a large multi-national company who

were interested in undertaking a health impact study to

determine the degree of heavy metal toxicity in a representative

sample of their work force. In addition, they were

interested in finding a cost-effective heavy metal chelator

that could be used in that part of the world where the

average monthly earnings do not exceed $150.

The amount of data analysed over the three-year period

amounts to more than 300 pages of statistics, so only the

pertinent results will be presented in this paper, along with

the methodology and other treatment protocols. More

than 20 natural compounds were used in the various protocols,

including various combinations of these, over three

separate trials with over 350 people participating.

The Discovery of a Unique

Natural Heavy Metal Chelator

© By Dr. J. Georgiou, Ph.D., N.D., DSc (AM)

1 World Health Organization (WHO) 1974, Florence, Italy 2 Goldman

LR, MW. Technical report: mercury in the environment:

implications for pediatricians.

American Academy of Pediatrics: Committee on Environmental Health.

Pediatrics (2001) Jul;108(1):197-205. 3 Goldman, LR., , MW.

and the Committee on

Environmental Health. Technical Report:Mercury in the Environment:

Implications for Pediatricians (RE109907) American Academy of

Pediatrics, Pediatrics, Volume 108,

Number 1, July 2001, pp 197-205. 4 Townsend Letter for Doctors, #

213, April 2001.

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Heavy Metal Detox

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Statistical analyses of all trials have shown that there was

one compound that consisted of three natural substances

that was successful in chelating all the metals tested using

a double blind, placebo controlled pre-post provocation

trial. Both urine and faeces samples were used for the

metal testing, determined by using both Inductively

Coupled Plasma – Mass Spectrometry (ICP-MS) and

Atomic Fluorescence Spectroscopy5. Both internal and

external laboratories were used for the testing both in

Russia as well as the USA.

Trial of a Number of Natural Substances

During the trials there were a number of natural

substances that were found to chelate certain metals, but

not others. There were also dose-dependent relationships

with some of these substances. However, there was only

one compound tested in double blind, placebo controlled

trials that was effective in mobilizing and excreting metals

in the urine and faeces for all the metals tested. This

proprietary formulation has been filed at the United Kingdom

Patent Office and an international patent is pending.

The compound is called HMD (Heavy Metal Detox) and

consists of a homeopathic homaccord of cell decimated

Chlorella, Coriandrum sativum leaf tincture (Cilantro)

and Chlorella Growth Factor. This is a powerful, synergistic

chelating formula, which is very cost effective.

The objective of this article is to introduce the results of

the HMD protocols, as well as touching on the results for

the other natural compounds tested, which is of interest

to other researchers in the field of heavy metals.

The Research Design

The research study involved the participation of a

group of medical doctors from a local hospital who also

formed the ethics committee. There were also a group

of analytical chemists from the plant, a group of nurses,

translators, secretaries, administrators and other experts in

analytical chemistry and spectrometers that took part in

the research over the three-year period.

All participation was on a voluntary basis, each person

signed a Consent Form, which had clear criteria for participation

in the research.

It was initially decided to take a representative sample

of employees from the metallurgical smelting plants, as

these were believed to be the higher risk areas in terms

of toxicity. Of a sample of 2,000 employees, a random

sample of 374 (18.7%) were chosen to undergo a Tissue

Hair Mineral Analysis (THMA)6 at a reputable laboratory

in the USA. Pubic hair was sent to the laboratory and

analysed for 8 different types of heavy metals, namely Sb,

U, As, Be, Hg, Cd, Pb and Al. There were also a further

15 minerals analysed.

It is recognised in the literature that THMA is a

unique, convenient and cost-effective screening method,

which reflects body minerals and heavy metal stores more

accurately than blood and urine, as hair naturally stores

minerals over time.7 The four main metals that were common

to all the workers were antimony, arsenic, cadmium

and lead, which were at very high levels. These metals

were the ones chosen for further study, as they were the

main by-products of the metal foundry's manufacturing

process and were the ones that the company wanted to

eliminate from their workforce.

Mercury was not really an issue as Russians do not use

amalgam fillings, but gold alloys, and seldom eat fish.

Studies are presently on-going, however, to determine

the efficacy of HMD with mercury and the results for

these should be published shortly. Initial pilot testing has

shown encouraging results – incorporated in the results is

a sample of 24 people that underwent pre-post provocation

testing for mercury using HMD.

The research design was a double blind, placebo-controlled

study – neither did participants, researchers nor

the analytical chemists doing the spectrometry analysis

know which treatment protocol each participant belonged

to. The coding was stored in the coordinators safe until it

was time to interpret the statistical data.

Methodology

Each participant had to acquire a baseline sample of

urine (24-hour collection) and faeces before commencing

to take any remedies. Both urine and faeces were taken

in order to determine the excretory route used by the

various substances tested.8 These samples were returned

to the research team and circumspectly recorded in

preparation for X-ray fluorescence spectrometry using

the foundry's in-house instrument. Further Inductively

Coupled Plasma – Mass Spectrometry (ICP-MS) analyses

were conducted using two independent laboratories

in Russia and the USA.

All the participants were given time off during the trials

as it was important for them not to continue being exposed

to the heavy metals during the pre-post testing period.

There were however two workers in the sample who continued

working during the trial due to work pressures.

After the baseline urine samples were collected for 24

hours and faeces as soon as the need arose, each participant

was given their precise detoxification remedy, which

they began to take three times per day (see Treatment Protocols

below). The post-provocation urine samples were

collected for 12 hours and the post-provocation faeces

samples after 48 hours later due to the slower transit time.

These samples were again returned to the research team,

coded and sent to the laboratory for analysis.

5 Dean, J.R. Atomic Absorption and Plasma Spectrometry (2nd

edition). Wiley, UK, 1997. 6 Passwater, RA. And Cranton, EM.

Trace elements, Hair Analysis and

Nutrition. Keats Publishing, Inc. New Canan, 1983. 7 Toxic Trace

Metals in Mammalian and Human Hair and Nails, EPA-600 4.049, August

1979, U.S. Environmental

Protection Agency, Research and Development. This is a review of 400

studies on hair analysis and toxic metals. 8 Angerer, J. and

Schaller, KH. Analyses of Hazardous

Substances in Biological Materials (Volume 4). VCH, Germany, 1994.

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Heavy Metal Detox

Explore! Volume 14, Number 4, 2005

All participants took certified metal-free, high-grade

Yaeyama cell-decimated Chlorella tablets9-13 (500 mg x 3

daily), from Japan in order to prevent the reabsorption

of metals from the gut due to the high levels of toxic

metals that were measured in these workers. This was

an added precaution to prevent any adverse reactions.

The placebo group also took this chlorella. The results

indicated that the chlorella by itself was not chelating

metals per se. Yaeyama Chlorella is grown in the environmentally

pristine coral reef region of Japan's Ishigaki

Island using mountain spring water, tropical sunshine

and food grade nutrients. High impact jet-spray drying

that pulverizes the algae wall breaks Yaeyama Chlorella

cell walls, making it into cell-decimated chlorella.14 The

pulverizing helps to increase absorption of its vital nutrients.

Furthermore, all the homeopathic homaccords used

in the study were prepared by a reputable homeopathic

pharmacy in the UK.

Statistical analysis was conducted using the Statistical

Package for the Social Sciences (SPSS)15. A biostatistician

was responsible for running all the analyses using

ANOVA, Pearson's correlation coefficients and other

descriptive statistics.

The Treatment Protocols

Over the three years there were a number of trials

conducted using different natural substances that the

literature supported as being effective chelators. It is

important to at least touch on these trials in order to

better understand what had been tested, and how. All the

374 workers that were initially screened using the THMA

took part in one of these trials. The various trials consisted

of the following:

1. Placebo or Control Group – taking only water

with a little cognac added to mask the taste. The

dosage was 60 drops x 3 daily.

2. Homeopathic Chlorella Group - this consisted of

a homaccord of homeopathic chlorella ranging

from 6c to 30c. Dosage was 60 drops x 3 daily.

3. Cilantro Group16 – taking Cilantro or Coriandrum

sativum leaf tincture. Dosage was 60 drops x 3 daily.

4. Chlorella Growth Factor, taken alone. Dosage was

60 drops x 3 times daily.

5. Homeopathic DMSA, using a homaccord of

homeopathic DMSA of 6c to 30c as a tincture.

Dosage was 60 drops x 3 daily.

6. PleoChelate17 – a ready-made remedy prepared

by Sanum-Kehlbeck, GmbH & Co, purported to

chelate metals. It consists of minerals in homeopathic

dosages of D2 in water. Dosage was 60

drops x 3 daily.

7. Homeopathic cell-decimated Chlorella + Chlorella

Growth Factor (CGF) + Cilantro in the form of

organic coriander sativum leaf tincture. Dosages

varied between 40, 50 and 60 drops x 3 times daily.

8. Homeopathic cell-decimated Chlorella + Chlorella

Growth Factor (CGF) + Cilantro in the

form of organic coriander sativum leaf tincture +

PleoChelate. Dosages varied between 40, 50 and

60 drops x 3 times daily.

9. Homeopathic cell-decimated Chlorella + Chlorella

Growth Factor (CGF) + Cilantro in the

form of organic coriander sativum leaf tincture +

PleoChelate + Homeopathic DMSA (homaccord

6c, 12c and 30c). Dosages varied between 40, 50

and 60 drops x 3 times daily.

10. Cilantro and vitamin C18-21 together. Cilantro

paste (see Summary of Various Protocols) was

taken at a dosage of one tablespoon daily with 2

grams of vitamin C x 3 times daily.

11. Cilantro, vitamin C and homeopathic lead, arsenic,

cadmium and antimony (homaccords of 6c

to 30c). The homeopathics were taken separately

as individual homaccords such as plumbum (60

drops x 3 daily) concomitantly with the Cilantro

paste (See Summary of Various Protocols) and the

vitamin C (dosage of 5 grams by 2 times daily).

9 Janusz Pempkowiak and Alicja Kosakowska. Accumulation of cadmium

by green algae Chlorella vulgaris in the presence of marine humic

substances. Environment

International Volume 24, Issues 5-6, July-August 1998, Pages 583-

588. 10 N. Akhtara, J. Iqbalb and M. Iqbal Removal and recovery of

nickel(II) from aqueous solution

by loofa sponge-immobilized biomass of Chlorella sorokiniana:

characterization studies. Journal of Hazardous Materials Volume 108,

Issue 1-2, 30 April 2004, Pages

85-94. 11 E. Beceiro-González*, A. Taboada-de la Calzada, E. Alonso-

Rodríguez, P. López-Mahía, S. Muniategui-Lorenzo and D. Prada-

Rodríguez Interaction between

metallic species and biological substrates: approximation to

possible interaction mechanisms between the alga Chlorella vulgaris

and arsenic(III). TrAC Trends in

Analytical Chemistry. Volume 19, Issue 8, August 2000, Pages 475-

480. 12 G. M. P. on and T. M. Florence Comparison of

physicochemical speciation procedures

with metal toxicity to chlorella pyrenoidosa. Analytica Chimica

Acta, Volume 209, 1988, Pages 97-109. 13 L. C. Rai, J. P. Gaur and

H. D. Kumar. Protective effects

of certain environmental factors on the toxicity of zinc, mercury,

and methylmercury to Chlorella vulgaris Environmental Research,

Volume 25, Issue 2, August 1981,

Pages 250-259. 14 Mitsuda, H., Nishikawa, Y., Higuchi, M., Nakajima,

K., Kawai, F. Effects of breaking of chlorella cells on the

digestibility of Chlorella protein. J Jpn

Soc Food Nutr. 1977; 30: 93-98. 15 Norusis, MJ. SPSS Professional

Statistics 6.1, SPSS Inc., Chicago, USA, 1994. 16 Omura Y; Beckman

SL Role of mercury (Hg)

in resistant infections & effective treatment of Chlamydia

trachomatis and Herpes family viral infections (and potential

treatment for cancer) by removing localized

Hg deposits with Chinese parsley and delivering effective

antibiotics using various drug uptake enhancement methods. Acupunct

Electrother Res, 1995 Aug, 20:3-4,

195-229. 17 Pleochelate – www.sanum.com 18 Carol, Spindell, Farkas.

Importance of interactions between nutrients and environmental

contaminants as a factor in

experimental design in toxicological research: with emphasis on

selenium and ascorbic acid The Science of The Total Environment,

Volume 9, Issue 2, March 1978, Pages

149-159. 19 Ariel H. B. Poliandria, Jimena P. Cabillaa, O.

Velardeza, Cristian C. A. Bodoa and Beatriz H. Duvilanski. Cadmium

induces apoptosis in anterior

pituitary cells that can be reversed by treatment with antioxidants.

Volume 190, Issue 1, 1 July 2003, Pages 17-24. 20 Poliandri,

AH.,Cabilla, JP.,Velardez, MO.,Bodo CC

and Duvilanski, BH. Cadmium induces apoptosis in anterior pituitary

cells that can be reversed by treatment with antioxidants.

Toxicology and Applied Pharmacology,

Volume 190, Issue 1, 1 July 2003, Pages 17-24. 21 Hande Gurer and

Nuran Ercal Can antioxidants be beneficial in the treatment of lead

poisoning? Free Radical Biology

and Medicine, Volume 29, Issue 10, 15 November 2000, Pages 927-945

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Heavy Metal Detox

Explore! Volume 14, Number 4, 2005

General Results for All Protocols

There were many trials using each remedy at different

doses, with different percentages of each substance,

in the various compounds tested. The data for all these

analyses run into hundreds of pages and cannot be shared in

the space available here. However, the data presented in Table 1

(N=160) shows the success (P) or failure (O) of these trials using

the above named natural substances. Success meant that there

was an increase in the specific metal in the post-testing, compared

to baseline for the group being tested as a whole. It is important

to bear in mind the stringent criteria that were used in this study

to include a remedy as being " successful " . To be considered a

successful

remedy it must have shown the ability to eliminate metals

in ALL the people involved in the particular trial.

Summary of Results for the

Various Compounds Tested

A brief summary of the results follows:

1. Chlorella Growth Factor22 by itself was only effective

at eliminating cadmium in faeces at a dosage

of 40 drops x 3 daily. The post-faeces sample had

150% more cadmium than the baseline sample.

2. The PleoChelate, a homeopathic mineral compound

produced by Sanum-Kehlbeck in Germany

that is used by many Biological Medicine specialists

was effective at chelating arsenic in urine only.

The dosage was 60 drops x 3 daily and there was

an average of about 500% increase of arsenic in the

post-urine test, compared to baseline.

3. The homeopathic DMSA, used at 50 drops x 3 daily,

showed elimination of cadmium in faeces (400%

increase) and arsenic in urine (1,200% increase).

4. Perhaps a word of caution about the Cilantro testing is in

order. Apart from one trial using 30 drops x 3 daily of Cilantro

where there was a 20% increase in the post-provocation

urine compared to the baseline, and one at 50 drops x 3 daily

where there was a 10% increase in the faeces of the postsample,

all other trials showed a strong percentage decrease

of metals in the post-urine and faeces. The levels were

consistently around 90 – 100% decrease in metals for all the

metals tested. This consistency and repetitiveness in results

is indicative that when Cilantro is used alone it is probably

removing metals intracellularly into the mesenchyme, but

as there are no other chelators to attach to the metals in

the mesenchyme, through the laws of osmosis (higher

concentration to lower concentration) the metals are going

back into the cell in force. The body is therefore withholding

more metals than the baseline or pre-provocation sample.

This " osmotic backlash " could prove detrimental for a

severely toxic person with chronic disease.

5. Homeopathic Chlorella did not eliminate any of

the metals in the post-provocation test.

Table 1 The Effectiveness of the Different Compounds Tested (N=220)

* NB. The Cilantro and vitamin C

trial was conducted using blood

samples, not faeces as indicated

in Table 1. The participants took

fresh Cilantro paste made from

1 Clove Garlic, 1 & #8260;2 cup Walnuts,

1 cup packed fresh Coriander

leaves, 2 tablespoons lemon

juice and 6 tablespoons olive

oil – one tablespoon at the

beginning and end of their

shifts. This was combined with

5 grams of ascorbic acid powder

every time they took the

Cilantro paste. The trial lasted

3 weeks or a total of 18 days.

Post-blood tests showed a

significant decrease in lead and

cadmium compared to baseline,

even though the workers were

still exposed to these metals

throughout the trial.

Treatment Pb Pb Cd Cd Sb Sb As As

(U) (F) (U) (F) (U) (F) (U) (F)

Chlorella Growth Factor O O O P O O O O

PleoChelate O O O O O O P O

Homeopathic DMSA O O O P O O P O

Cilantro tincture * * * * * * * *

Homeopathic Chlorella O O O O O O O O

Homeopathic Chlorella+

CGF+ Cilantro P P P P P P P P

Homeopathic O O O O O O

Chlorella+CGF+ P P

Cilantro+PleoChelate O O O O O O O O

Homeopathic Chlorella+

CGF+Cilantro+PleoChelate+

Homeopathic DMSA

O O O O O O O O

Cilantro + vitamin C O P* O P* O O O O

Cilantro + vitamin C +

homeopathic plumbum P* O O O O O O O

Cilantro + vitamin C +

homeopathic arsenicum O O O O O O O O

Cilantro + vitamin C +

homeopathic antimonium O O O O O O O O

Cilantro + vitamin C +

homeopathic cadmium O O P* O O O O O

22 Kanno, T.,Shinpo, K and Masada, M. Growth-promoting factor for

yeast from an extract of Chlorella vulgaris CK-5 : Seibutsu-kogaku

74: 159–162. 1996.

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Explore! Volume 14, Number 4, 2005

6. The Homeopathic Chlorella, CGF and Cilantro

compound that is now known as HMD showed

the most promise as it eliminated ALL the metals

tested, both through the urinary as well as the biliary

route. The results for this compound are shown

in Table 2 for the urine and Table 3 for the faeces.

The elimination of the four metals is compared to

the placebo trials. Once it was established that the

homeopathic Chlorella + Cilantro + CGF was the

most promising compound, this was further tested

amongst 84 foundry workers to determine the exact

percentage of each substance in the compound, as

well as the dose that was most effective for each of

the metals tested.

Eventually, after conducting pre-post urine and faeces provocation

testing on these 84 workers the most effective

mixture was found that eliminated all metals from the

body as measured by ICP-MS and X-ray fluorescence

in the post-urine and post-faeces samples.

7. When PleoChelate was added to the HMD compound,

there was only elimination of cadmium

and arsenic in faeces. The dosage that was most

effective for the arsenic in faeces was 50 drops x 3

daily (100% elimination) and 40 and 50 drops for

the cadmium in faeces (200% elimination).

Detailed Results of the HMD Compound Trials

The only compound that was effective at mobilizing

and eliminating all metals was HMD consisting of

Homeopathic chlorella, chlorella growth factor (CGF)

and Coriandrum sativum leaf tincture.

As this particular compound showed merit on a number of

occasions, it was tested thoroughly in double-blind, placebo

controlled trials with an additional 84 foundry workers to

determine the exact dosage that was most effective, as well as

the exact proportions of each element of the compound that

would be the most effective at eliminating metals.

The results will be presented for each metal in urine

and then in faeces. The results are expressed as percentage

increases (+) or percentage decreases (-) of heavy metals

in urine or faeces. If there is a percentage increase in the

post-provocation sample, this is an indication that the body is

eliminating these metals from the body – an indication that

the chelating agent is mobilizing and eliminating the metals.

A percentage decrease is an indication that the body may actually

be retaining metals, which is not the desired response and

could be detrimental to a person's overall health. When the

percentage is close to zero then the body is not eliminating or

storing metals. The criteria for choosing a successful remedy

was that the Total Mean (%) in the group of people being

tested had to be positive (percentage increase) – the higher

the positive number, the more metals were being eliminated.

Given that the trials also involved testing the specific percentages

of each element in the effective HMD compound,

the best results of these trials have been taken, as the data is

too extensive to present here. The most effective proprietary

combination has been used in the final HMD compound

presently available to practitioners and the public.

Table 2 shows the mean elimination of metals in URINE

in the post-provocation sample of urine after the HMD was

taken for 12 hours only. There is a dose-dependent relationship

for each of the four specific metals tested. For example,

arsenic was eliminated more effectively when taking 40 drops

x 3 daily (7,514% increase in the post-urine), compared to

higher doses of 50 and 60 drops. Antimony also showed the

same dosage of 60 drops x 3 daily was the most effective. The

cadmium data were rather surprising as only the 50 drops x 3

daily were effective (26.43%); none of the other two dosages

were effective. The lead elimination peaked when a dosage

of 60 drops x 3 daily was used (466.4%).

Table 3 shows the same but for the elimination of metals

in the FAECES. For arsenic the 60 drops x 3 daily was most

effective (298.1%); for antimony only the 60 drops x 3 daily

was effective (50%); for cadmium the 40 drops x 3 daily

(45.11%) and for lead only the 50 drops x 3 daily (142.1%).

Arsenic Antimony Cadmium Lead

Placebo Group 104.87 14.91 -20.50 -16.95%

Homeopathic

Chlorella+CGF+

Cilantro

40 50 60 40 50 60 40 50 60 40 50 60

7,514 784.1 1,440 60.7 48.8 59.1 0 26.43 0 335.5 0 466.4

Table 2 Results of the HMD Testing In Urine (N=84)

(Mean elimination of metals expressed as % increase or decrease)

Arsenic Antimony Cadmium Lead

Placebo Group 61.13 14.91 -22.62 -6.01

Homeopathic

Chlorella+CGF+

Cilantro

40 50 60 40 50 60 40 50 60 40 50 60

52.57 163.7 298.1 0 0 50 45.11 26.4 43.13 0 142.1 0

Table 3 Results of the HMD Testing In Feaces (N=84)

(Mean elimination of metals expressed as % increase or decrease)

40 = 40 drops x 3 daily;

50 = 50 drops x 3 daily;

60 = 60 drops x 3 daily

40 = 40 drops x 3 daily;

50 = 50 drops x 3 daily;

60 = 60 drops x 3 daily

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The predominant route of excretion is via the urine, which

will enhance the excretion rate of the mobilized metals as

compared to the fecal route, decreasing the possibility of

reabsorption

through the bowel, particularly in cases of leakygut

syndrome, therefore decreasing the burden on the liver.

Additional Mercury Research

To date, a clinical sample of 24 patients with amalgam

fillings have taken the HMD in pre-post provocation

tests using a 2-hour protocol. Urine was taken from

the patient immediately after obtaining permission, the

HMD was given in a single dose of 60 drops and a second

urine sample was taken approximately 2 hours later. This

was arranged like this for patients visiting the Integrated

Medicine Centre in Cyprus for convenience. Samples

were analysed using a dedicated PSA Atomic Fluorescence

Mercury Analyser capable of detection limits up to parts

per trillion. The results are shown in Table 4.

Provocation with

HMD (60 drops) MERCURY

Pre-test +12.62%

Post-test + 126.40%

The results from this pilot study for mercury show that the

HMD is eliminating just over 100% mercury in the posturine

sample compared to the pre-test urine. This study with

mercury is still on-going with complete pre-post provocation

trials using HMD over 24 hour collection for the pre-test

urine and 12 hours for the post. This is also being correlated

to the amount of amalgam fillings in the mouth.

Other Health Benefits of HMD

The three individual elements that HMD consists of

are all natural substances, which apart from their chelating

properties also have other health benefits such as:

1) Chlorella Growth Factor (CGF)

In the 1950s, Dr. Fujimaki, of the People's Scientific

Research Center in Tokyo, separated a substance from

a hot water extract of chlorella by electrophoresis. He

found this hot water extract promoted the healthy growth

of human children as well as young animals. Because of

this growth-promoting effect discovered in the early

experiments with chlorella extract, it was named Chlorella

Growth Factor (CGF). Scientific research indicates

that regular use of Chlorella Growth Factor prevents heart

disease23, and reduces high blood pressure24 and serum

cholesterol levels.25-27

Chlorella Growth Factor (CGF) derived its name

because laboratory test indicated that the addition of

CGF to a standard growth medium increased the growth

of friendly bacteria, lactobacillus, by up to 400%.28-29

CGF is a nucleotide-peptide complex and in addition

to playing a synergistic role in the chelation of metals as

used in HMD, CGF has many other benefits such as:

t It stimulates growth.30

t It stimulates and builds the immune system.31

t Act as a hepato-protective agent.32-33

t It improves cellular efficiency and integrity.

t It helps to detoxify other xenobiotics.34-35

t It strengthens the body's ability to recover quickly

from exercise and disease.

t It mitigates some side-effects of chemo and/or

radiation treatment.

t It can lower blood sugar levels.36-37

t It combats damaging free radicals.

t It enhances production of interferon.

t It accelerates and enhances the re-growth of

damaged tissue even when ulcerated, burnt and

resistant to other healing modalities.

t It activates cellular functions and increases

metabolism.

t It normalizes the metabolism of fats.

t It activates protein synthesis.

t It regulates liver and kidney functions.

t It increases the growth of beneficial bacteria in

your colon.

t It promotes rapid healthy growth in children

without adverse side effects.

t It enhances RNA/DNA functions responsible for

the production of proteins, enzymes and energy at

the cellular level.

t It helps you to resist the effects of premature aging.

t It encourages the rejuvenation of the body's own

DNA/RNA, thus you will look and feel younger,

typically beginning with visible positive changes as

it strengthens and improves hair, skin, and nails.

Table 4 Results of the HMD Testing in Urine for Mercury (N=24)

(Mean elimination of metals expressed as % increase or decrease)

23 Wang, LF., Lin, JK and Tung, YC. Effect of Chlorella on the

levels of glycogen triglyceride and cholesterol in ethionine treated

rats. J Formosan Med. Assoc., 79, 1, 1980. 24 Mutai,

M. Effects of Chlorella phospholipids on the aortic collagen and

elastin metabolism and on the serum lipid content in rats with

experimental arteriosclerosis. Exper. Mol. Pathol., 37,

150, 1982. 25 Okuda, M., Hasegawa, J., Sonoda, M., Okabe, T. and

Tanaka, Y. The effects of Chlorella on the levels of cholesterol in

serum and liver, Jpn. J. Nutr,. 33, 3, 1975. 26

Hashimoto, S., Setoyama, T., Yokokura, T. and Mutai, M. Effects of

soybean phospholipids, Chlorella phospholipids, and clofibrate on

collagen and elastin synthesis in the aorta and

the serum and liver lipid contests in rats. Exper. Mol. Pathol., 36,

99, 1982. 27 Sano, t. and Tanaka, Y. Effect of dried, powdered

Chlorella vulgaris on experimental atherosclerosis and

alimentary hypercholesterolemia in cholesterol-fed rabbits. Artery,

14, 76, 1987. 28 Sano, T., Kumamoto, Y., Kamiya, N., Okuds, M. and

Tanaka, Y. Effects of lipophilic extracts of

Chlorella vulgaris on alimentary hyperlipidemia in cholesterol fed

rats. Artery, 15, 217, 1988. 29 Lin, YC. The supplementary effect of

algae on the nutritive value of soybean milk.

J Formosan Med. Assoc., 68, 15, 1969. 30 Ishibashi, M. Effects of

Chlorella feeding on rats. I. Effects on growth, Bull. Azabu. Vet.

Coll., 22, 125, 1971, in Biol Abstr., 54, 9694,

1972. 31 Miyazawa, Y., Murayama, T., Ooya, N., Wang, LF.,Tung,

YC.,Yamaguchi, N. Immunomodulation by unicellular green algae

(Chlorella pyrenoidosa) in tumour bearing

mice. J Ethnopharmacol. 1988; 24:135-146. 32 Fink, H. and Harold, E.

The protein value of unicellular green algae and their action in

preventing liver necrosis, Zeitscher Physiol.

Chem., 305, 182, 1956. 33 Wang, LF., Lin, JK and Tung, YC.

Protective effect of Chlorella on the hepatic damage induced by

ethionine in rats. J. Formosan Med. Assoc., 78, 1010,

1979. 34 Kumamoto, S., Method of Human Cell Culture. US patent

4,468,460, 1984. 35 Pore, RS. Detoxification of chlordecone poisoned

rats with Chlorella and Chlorella derived

sporopollenin. Drug Chem. Toxicol. 1984; 7 (1): 57-71. 36 Lee, H.T.,

Lai.,JE and Tung, YC. Hypoglycaemic action of Chlorella, J Formosan

Med. Assoc., 76, 272, 1977. 37 Gray AM,

Flatt PR. Insulin-releasing and insulin-like activity of the

traditional anti- diabetic plant Coriandrum sativum (coriander). Br

J Nutr 1999 Mar;81(3):203-9.

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Heavy Metal Detox

Explore! Volume 14, Number 4, 2005

2) Coriandrum sativum (leaf ) herbal tincture –

commonly referred to as Cilantro

A researcher named Dr. Yoshiaki Omura, using bioenergetic

measures, discovered that some patients excreted

more toxic metals after consuming a Chinese soup containing

cilantro. Cilantro is the leafy part of a common

herb whose seed, coriander, is a familiar culinary spice.

Cilantro has a health-supporting reputation that is high on

the list of the healing spices. Cilantro has been well-researched

and has been found to have the following benefits:

v Blood sugar lowering properties37

v Anti-inflammatory properties – contains flavonoids

include quercitin, kaempferol, rhamnetin, and

epigenin

v Free radical scavenger and prevents lipid

peroxidation38-39

v Antimicrobial properties due to its rich volatile

oils such as carvone, geraniol, limonene, borneol,

camphor, elemol, and linalool. Research by

Mexican and US researchers has isolated the

compound dodecanal – which laboratory tests

showed is twice as effective as the antibiotic

gentamicin at killing Salmonella.40-41

This research also looked at using Coriandrum sativum

seed tincture – this was also effective in a number of trials

and is certainly worthy of further study.

3) Homeopathic Cell-Decimated Chlorella

The chlorella vulgaris was made into a homeopathic

homaccord of three different potencies from 6C to 30C.

The literature is full of data about chlorella purporting to

detoxify heavy metals. Homeopathic chlorella was tested

based upon initial results using homeopathic plumbum,

arsenicum, antimonium and cadmium. These homeopathics

did appear to have some chelating properties to

the specific metal that they represent, probably based

upon their resonating properties. When homeopathic

chlorella was tried by itself there was no chelating effect.

But when combined with the other natural remedies there

seems to be a powerful synergistic effect.

Recent research at the University of Kalyani in West

Bengal, which was reported in New Scientist, 2003, has

shown the efficacy of homeopathic Arsenicum oxide in

the detoxification of arsenic in mice which had a hepatoprotective

effect.42

Dose-Dependent Relationship

These three natural remedies mentioned above were

mixed together in various ratios. The combinations of the

different elements of the compound in varying percentages

did play an important role in the efficiency of their

chelating characteristics.

The Power of the Compound depicts the efficacy of its

chelating power as measured by the percentage increase of

metals from the body (urine and faeces) in the post-provocation

sample compared to the pre-provocation sample.

The Premium chelator was the one that worked most

effectively when taking the average elimination, over all

the four metals measured. The Moderate chelator was the

one that worked second-best and the Poor chelator was the

one that worked the least when compared to the others.

The author wishes to keep the various ratios proprietary

for the time being. The HMD compound presently on

the market, however, is the Premium Chelator.

Treatment Protocols Using HMD

The vast amount of data collected clearly showed that

there was a dose-dependent relationship depending on what

metal was being chelated. As has already been discussed, for

some metals, the minimum dose of 40 drops x 3 daily was

the most effective, for others 50 drops x 3 daily and others

the maximum dose of 60 drops x 3 daily.

In order to gain maximal effectiveness of the one

compound, it would be wise to rotate the dosage on a

daily basis as follows:

Morning dose: 40 drops

Lunchtime dose: 50 drops

Dinner time: 60 drops

Following this dosage protocol, all metals will be chelated

on a daily basis, be it in a rotational fashion. It is the

author's belief that it is impossible to completely remove

all the metal stores from the body, one can only reduce the

toxic amounts over time. Continual detoxification would

also overburden the kidneys and liver, as well as mobilizing

metals around the body and re-storing in different sites that

may be more detrimental. It is therefore strongly recommended

that the HMD be taken in rotation, along with

other natural substances that will help to chelate the metals

being released intracellularly, such as chlorella vulgaris, as

well as a few grams of vitamin C daily. It is best to begin

the elimination slowly – taking only 20 drops x 2 daily for

the first 6 days of the protocol, then increasing this to the

40, 50 and 60 drops taken morning, lunch and evening

respectively, before food. It is highly recommended to take

the HMD only 6 days of the week, allowing one day's rest

to allow the liver and kidneys to recover.

It is the author's belief that HMD can be taken over

long periods of time. Apart from the heavy metal chelating

effects, the individual ingredients have been well

researched and have been found to have many other

benefits such as immune modulation, hepato-protective

38 Chithra V, Leelamma S. Coriandrum sativum changes the levels of

lipid peroxides and activity of antioxidant enzymes in experimental

animals. Indian J Biochem Biophys

1999 Feb;36(1):59-61. 39 Chithra V, Leelamma S. Hypolipidemic effect

of coriander seeds (Coriandrum sativum): mechanism of action. Plant

Foods Hum Nutr 1997;51(2):

167-72. 40 Delaquis PJ, Stanich K, Girard B et al. Antimicrobial

activity of individual and mixed fractions of dill, cilantro,

coriander and eucalyptus essential oils. Int J

Food Microbiol. 2002 Mar 25;74(1-2):101-9. 41 Kubo I, Fujita K, Kubo

A, Nihei K, Ogura T. Antibacterial Activity of Coriander Volatile

Compounds against Salmonella

choleraesuis. J Agric Food Chem. 2004 Jun 2;52(11):3329-32. 42 BMC

Complementary and Alternative Medicine, Vol 3., p.7., 2003.

8

Heavy Metal Detox

Explore! Volume 14, Number 4, 2005

effect, antimicrobial, anti-inflammatory, lowering blood

sugar, normalizes fat metabolism and increases levels of

interferon. Where clinical heavy metal testing using a

pre-post provocation test has shown high levels of metals

it is recommended that HMD be taken for a period of 3-6

months consecutively; 6 days per week with one day rest.

Biochemical Analyses

In addition to examining the heavy metals, blood was

also taken from a random sample of the 84 workers tested

with HMD and analysed for a variety of clinical parameters.

The main components tested were liver function (bilirubin,

protein albumin, Alanine Aminotransferase (ALT), Aspartate

Aminotransferase (AST), Thymol and kidney function (urea,

phosphorus, creatinine and uric acid).

The main purpose of correlating the pre-post

biochemical blood tests with the detoxification protocols

was to determine whether there was any undue stress on

the kidneys and liver, which are the main detoxification

organs involved during the elimination of heavy metals

from the body. Particularly with such a toxic population

of people, it is important to ascertain the possible sideeffects

of the chelating protocols, as well as the stresses on

the organ systems of the body.

Conclusions of Biochemical Tests

On all the blood chemistry tests measuring a variety

of kidney and liver functions, there was no significant

changes that would indicate that the detoxification

organs were under undue stress, or that there was any

deterioration of tissues or other organs.

Perhaps that the detoxification remedy is made

of natural substances and do not consist of synthetic

chemicals is one reason why there are no adverse

detoxification reactions. There were also no reports of

people undergoing any type of detoxification reactions

whatsoever during the 48-hour detox trial. This data is

encouraging, as one of the problems in using synthetic

substances such as DMPS, EDTA and DMSA with a very

toxic population is the severity of the detox reactions.

Heart Rate Variability Testing

Heart Rate Variability (HRV) is a test of Autonomic

Nervous System (ANS) functioning. The ANS is

connected to all organs and systems of the body, so

indirectly we are really measuring the level of physiological

functioning of all the systems of the body. We are also

measuring the level of adaptive response of the autonomic

nervous system – the healthier the ANS, the better it will

adapt to changes in the environment.

The HRV data showed the pre-post changes during

the 48 hours of the treatment trial. Even though the

time period was relatively too short to record significant

improvements in ANS functioning, there were 8 out of

a total of 20 people who had significant improvements

in the functioning of their physiological systems. If more

time were available it would be possible to follow these

people and take HRV measurements every week for at

least a month during the use of the HMD.

Conclusions

This brief presentation of this three year research study

to determine a cost-effective and safe metal chelator that

can be used on a mass scale in metal foundries, as well as

by the general population, has clearly shown that HMD

has proven to be an effective chelator for all the four

metals tested and has shown promise in the chelation of

mercury during the pilot study.

There is certainly more research to conduct to determine

the efficacy of HMD with other metals, including

mercury. Preliminary trials have already begun and show

encouraging results. This research will be on-going and

the results will be presented in further publications.

One factor that is being investigated is the energizing of

HMD using Miron glass bottles43 as well as other methods

of energizing the specific ingredients being tested. This work

is again underway, and has shown very encouraging results

to date. Therefore, all the HMD presently being sold at

www.worldwidehealthcenter.net is bottled in Miron glass and

a proprietary process has energized the ingredients. Miron

glass provides the benefits of superior protection from light

degradation, increased shelf life, energizing effects on organic

molecular life, natural preservation and refinement of healing

properties as well as providing attractive packaging. The

secret of Miron Violet Glass is based on the fact that violet

spectral range (720 - 770 Bio hertz) permanently activates and

energizes the molecular structure, and the healing energies of

substances stored in the Miron Violet Glass don't " escape " .

This is exciting work that clearly shows the powerful

effects of synergy as well as the use of natural substances in

the removal of toxic metals from the body. There is still a

considerable amount of work that needs to be completed

in the embryonic science of toxicology, heavy metals and

their removal from the body tissues and organs. d

Further information on HMD and other issues relating to

heavy metal toxicity can be found at www.heavymetaldetox.net

ABOUT THE AUTHOR

Dr. Georgiou has been an active clinician for 25 years, and Natural

Medicine Director and Founder of the Integrated Medicine Centre, in

Larnaca, Cyprus (www.integratedmedicinecentre.com), which specializes

in many aspects of Integrated Medicine. He has 9 degrees and diplomas

in Natural Medicine from the UK and USA including the Biological

Sciences, Clinical Nutrition, Naturopathy, Herbal Medicine,

Iridology,

Homeopathy, Su Jok Acupuncture, Clinical Psychology and Clinical

Sexology as well as specialized training in VEGA bio-dermal screening

and bioresonance, Live Blood Analysis, Thermography, Heavy Metal

testing using spectrometers, and other modalities. He is the

International

European Director for the University of Natural Medicine and founder

of

the College of Natural Medicine in Cyprus. drgeorge@...

43 http://www.luminanti.com