Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 Dave, You may want to check over on Autism_LDN/ as there is at least 1 person there with Crohns using ldn. > > I'm new here. I am seeking input, both good and bad from people who > have taken LDN for Crohns. > Dave D > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 Hi Dave, I will forward on some earlier messages from the site regarding Cronhs. Many people have had success with LDN, and there is a trial that appears to be very promising. Welcome to the group Aletha [low dose naltrexone] LDN for Crohns > I'm new here. I am seeking input, both good and bad from people who > have taken LDN for Crohns. > Dave D > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 That is very good that Dr. Zagon is part of the research team. Is there a reason why I should be surprised? Kindest of regards Aletha [low dose naltrexone] LDN for Crohns> > > > I'm new here. I am seeking input, both good and bad from people who> > have taken LDN for Crohns.> > Dave D> >> >> >> >> >> > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 Hi Dave, Here's some info for you ... Regards, Cris 1) Digestive Diseases Week Conference, Los Angeles - May 2006 - PRESENTATION ABSTRACT ID#S1397 - TITLE: Low-Dose Naltrexone as a Treatment For Active Crohn's Disease - AUTHORS: J. P. ; H. E. Stock; S. I. Bingaman; D. T. Mauger; I. S. Zagon - SESSION TITLE/SESSION TYPE: Clinical Intestinal Disorders: Inflammat..., Poster Session - PRESENTATION DATE/TIME: Sun, May 21, 8:00 AM - LOCATION: West Hall A (LA Convention Center). Low-Dose Naltrexone as a Treatment For Active Crohn's Disease J. P. (1); H. E. Stock (1); S. I. Bingaman (1); D. T. Mauger (2); I. S. Zagon (3) 1. Medicine, The Pennsylvania State University College of Medicine, Hershey, PA, USA. 2. Health Evaluation Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA. 3. Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA. Background and Aims: Endogenous opioids and opioid antagonists have been shown to play a role in healing and repair of tissues. In an open-labeled pilot prospective trial, the safety and efficacy of low-dose naltrexone (LDN), an opioid antagonist given at a dosage that exacerbates opioid- opioid receptor interactions, was tested in humans as a treatment for active Crohn's disease. Methods: Eligible subjects with histologically and endoscopically confirmed active Crohn's disease with a Crohn's Activity Index (CDAI) score of 220-450 were enrolled in a study using 4.5 mg naltrexone/day. Subjects were required to be off infliximab for at least 8-weeks, and this medication was not allowed during the trial. Other drug therapy for Crohn's disease utilized 4 or more weeks prior to enrollment was continued at the same dosages. Patients completed the Inflammatory Bowel Disease Questionnaire (IBDQ) and the Short-form (SF-36) quality of life (QOL) surveys before treatment, every four weeks on therapy, and 4-weeks after completion of the study drug. Drug was administered orally each evening for a 12-week period. Laboratory tests, erythrocyte sedimentation rates, C-Reactive protein, and CDAI scores were assessed monthly and 4 weeks after discontinuing the medication. Results: Seventeen patients with a mean initial CDAI score of 356 ± 27 were enrolled in the study. CDAI scores decreased significantly (p<0.01) with LDN, and remained statistically lower than baseline 4-weeks after completing therapy (see Figure). Eighty-nine percent of patients exhibited a response to therapy (>70-point decrease in CDAI, p<0.001) and 67% achieved remission (CDAI score <150). QOL surveys indicated marked improvement with LDN. No laboratory abnormalities were noted. One subject undergoing routine endoscopic procedures showed healing of the intestinal mucosa. In both subjects with open fistulas, closure was noted with LDN. The most common side effect of LDN was sleep disturbances (7 patients). Conclusions: LDN therapy offers an alternative safe, effective, and economic means of treating subjects with active Crohn's disease. http://ddw2006.abstractcentral.com/planner 2) Digestive Diseases Week Conference, Los Angeles - May 2006 PRESENTATION ABSTRACT ID# T1155 - TITLE: The Opioid Antagonist Naltrexone Alleviates Chemically-Induced Colitis- AUTHORS: G. L. Matters, J. F. Harms, L. R. Fitzpatrick, A. M. Parikh, N. J. Nilo, J. P. . SESSION TITLE/SESSION TYPE: Consequences of Intestinal Inflammation, Poster Session - PRESENTATION DATE/TIME: Tue, May 23, 8:30 AM - LOCATION: West Hall A (LA Convention Center). The Opioid Antagonist Naltrexone Alleviates Chemically-Induced Colitis G. L. Matters (1); J. F. Harms (2); L. R. Fitzpatrick (3); A. M. Parikh (2); N. J. Nilo(2); J. P. (2) 1. Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA. 2. Medicine, The Pennsylvania State University College of Medicine, Hershey, PA, USA. 3. Surgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA. Background and Aims: Endogenous opioids have been shown to influence inflammatory responses through the modulation of cytokine production. Additionally, opioid antagonists promote tissue growth and repair. It was hypothesized that the opioid antagonist naltrexone could reduce inflammation and promote repair of the bowel in a chemically-induced mouse model of inflammatory bowel disease. Methods: Forty-eight C57BL/6J mice were divided into two groups: one received untreated drinking water and the other received 2% dextran sodium sulfate (DSS) for 5 days. On the third day after DSS was introduced, 8 animals in each group were injected subcutaneously with 0.1 ml saline (control) or naltrexone (NTX, 0.1 or 10 mg/kg) daily for 5 days. Disease activity index (DAI) scores, based on weight loss and stool hemoccult, were calculated daily. Mice were necropsied on day 9 and inflammation of the distal colons was analyzed histologically. Colonic RNA was evaluated by microarray and real-time RT-PCR. Results: By day 4, DSS-treated animals had significant weight loss (p = 0.006) and a higher DAI score (p < 0.001) compared to water controls. At necropsy, DSS-treated mice that received NTX (10 mg/kg) had less weight loss (30.8%), lower DAI scores (24.6%), and less inflammation (25.0%) compared to DSS mice that received only saline. Real-time RT-PCR demonstrated an increased expression of the cytokines IL-6 and IL-12 in DSS-treated mice. The increase in these pro-inflammatory cytokines was reversed by NTX treatment to levels near or equal to the expression in mice without colitis. Furthermore, the expression of the transcription factors STAT3 and STAT4, downstream effectors of cytokine signaling, was upregulated in the colons of DSS-treated mice and similarly reversed by NTX. Conclusions: NTX treatment reverses the disease manifestations and histologic evidence of inflammation in DSS-induced colitis. The mechanism by which NTX acts to reverse colitis is related in part to the decreased expression of pro-inflammatory cytokines (IL-6 and IL-12) and their downstream mediators (STAT3 and STAT4). http://ddw2006.abstractcentral.com/planner# > > [low dose naltrexone] LDN for Crohns > > > > > > > I'm new here. I am seeking input, both good and bad from people who > > > have taken LDN for Crohns. > > > Dave D Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2006 Report Share Posted October 24, 2006 dave if you go www.lowdosenaltrxone.org and you can go to the 2006 conference and you can listen to an entire audio of Dr Jill who is doing really incredible work in the field of Cronhns with ldn. cyndi On Oct 23, 2006, at 10:47 PM, Aletha Wittmann wrote: > Hi Dave, > > I will forward on some earlier messages from the site regarding > Cronhs. > Many people have had success with LDN, and there is a trial that > appears to > be very promising. > > Welcome to the group > Aletha > [low dose naltrexone] LDN for Crohns > > >> I'm new here. I am seeking input, both good and bad from people who >> have taken LDN for Crohns. >> Dave D >> >> >> >> >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 1, 2006 Report Share Posted November 1, 2006 What about Colitis Ulcerosa, I don\t find that mentioned on the ldn info site.. Geir Flatabø On 10/24/06, Cyndi Lenz <psychrn@...> wrote: > dave if you go www.lowdosenaltrxone.org and you can go to the 2006 > conference and you can listen to an entire audio of Dr Jill > who is doing really incredible work in the field of Cronhns with ldn. > cyndi > On Oct 23, 2006, at 10:47 PM, Aletha Wittmann wrote: > > > Hi Dave, > > > > I will forward on some earlier messages from the site regarding > > Cronhs. > > Many people have had success with LDN, and there is a trial that > > appears to > > be very promising. > > > > Welcome to the group > > Aletha > > [low dose naltrexone] LDN for Crohns > > > > > >> I'm new here. I am seeking input, both good and bad from people who > >> have taken LDN for Crohns. > >> Dave D > >> > >> > >> > >> > >> > >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 2, 2006 Report Share Posted November 2, 2006 > > What about Colitis Ulcerosa, > I don\t find that mentioned on the ldn info site.. > > Geir Flatabø > ========= Go back to the LDN website, ulcerative colitis is listed next to the bottom under other diseasess. Look at the list of diseases, one side is cancers the other side is other diseases and ulcerative colitis is on that list under other diseases. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 2, 2006 Report Share Posted November 2, 2006 Hi Geir, I have a friend with UC. She has not yet started LDN as we are looking for doctor for her to prescribe it. When we asked if anyone else has tried LDN with UC, we found 2 people that said it has worked well. You can also try coconut oil. You should start out with only 1 teaspoon a day and slowly build yourself up to 2 to 4 tablespoons a day. My friend has started that a week ago. You can cook with it, put it a smoothie, add in your baking or even rub it on your skin. My best Aletha [low dose naltrexone] LDN for Crohns > > > > > >> I'm new here. I am seeking input, both good and bad from people who > >> have taken LDN for Crohns. > >> Dave D > >> > >> > >> > >> > >> > >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2006 Report Share Posted December 10, 2006 > > Is anyone aware of doctors in the New England area (specifically MA) who > will perscribe LDN for Crohns? > Go to this site and ask . She'll help you. http://ldn.proboards3.com/index.cgi Quote Link to comment Share on other sites More sharing options...
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