Guest guest Posted April 30, 2005 Report Share Posted April 30, 2005 There's really nothing I could add that the " Final diagnosis " and the " In summary " paragraphs don't already say. From a pathologist's point of view, it's crescentic glomerulonephritis with predominance of IgA. So, clinically, it shows strong evidence of either IgA nephropathy or HSP (HSP causes secondary IgA nephropathy which is identical to just IgA nephropathy by itself). The fact that it's crescentic means there is a potential for it to be rapidly progressive, and so, treatment at the more aggressive end of the spectrum for IgAN might be justified (ie. immunosuppressants, chemotherapy) Pierre BIOPSY REPORT > Well, I finally got a copy of my sons biopsy report, I was wondering if > anyone can make sense > of this for me. I am sorry it is so long, but I would really appreciate > any feed back to better understand this disease. > > Final Diagnosis- renal biopsy with crescentic glomreulonephritis withiga > predominant glomerular immune deposits consistent with iga immune complex > disease. > > Note: The biopsy contains 28 glomeruli adn 12 have segmental celluar ro > fibrocellular crescents. The remaining glomeruli have segmental > endocapillary porliferative changes with capillary basement membrane > reduplication, neutrophilic infiltrates and mesangial cell proliferation. > There is patchy intestinal fibrosis and renal tubular atrophy involving up > to 15% of the biospy. There is a spares mixed cellular interstitial > infiltrate. The renal blood vessels are unremarkable. Immunofluorescent > studies reveal predominant glomerular deposits of IGA and deposits of C3. > Electron microscopic analysis reveals electron dense deposits in > mesangial, subendothelial and intramembranous locations. There is > segmental basement membrane reduplication and mesangial cells > interposition. There is segmental epithelial cell foot proces fusion. > > In summary this is a crescentic glomerulonephritis of IGA etiology. > Clinical correlation should consider HS purpura and IGA nephropathy. > > Immunoflourescence reveal the following findings: glomeruli and > interstitium tubules, vessels > > IgG (2) negative > IgA (2) 1+ to 2+, diffuse, global, granular stainging in the mesangium > and Negative. > in some cappillary walls, with a segmental, peripheral capillary wall > pattern. > > IgM (2) trace +, diffuse, global, granular staining in the mesangium and > Negative. In some capillary walls, with a gegmental, jperipheral > capillary wall pattern. > > C3 (2) Trace + to 1+ diffuse, global, granular staining in the meseangium > +, granular staining in some vessel walls, and in some ca pillary walls, > with a segmental, peripheral capillary wall pattern. > > C4 (2) negative > Clq (1) negative > Fibrinogen (1) faint trace + to trace+, global, granular to irregular > staining Negative. > in the mesangium and in some capillary walls. > > Kappa immunoglobulin light chains (2) Faint trace+ to trace+, diffuse, > negatie. global, granular staining in the mesangium and in some capillary > walls, with a segmental, peripheral capillary wall pattern. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 30, 2005 Report Share Posted April 30, 2005 Hi Pierre, Thanks so, much for your response. I guess the hard part of this disease is the not knowing what will happen to his kidneys or how soon, if ever he may need a new kidney. Its been almost a year now since he was diagnosed, and we have made progress as far as his protein loss goes. He is down to 4+_which I know is still high, but he started out at over 16,000 miligrams, he will be off the prednisone in 4 more weeks and will be starting cellcept. I hope your doing well, I wasn't able to catch up on all posts since, I got back from our disney vaction. Lachaine wrote: There's really nothing I could add that the " Final diagnosis " and the " In summary " paragraphs don't already say. From a pathologist's point of view, it's crescentic glomerulonephritis with predominance of IgA. So, clinically, it shows strong evidence of either IgA nephropathy or HSP (HSP causes secondary IgA nephropathy which is identical to just IgA nephropathy by itself). The fact that it's crescentic means there is a potential for it to be rapidly progressive, and so, treatment at the more aggressive end of the spectrum for IgAN might be justified (ie. immunosuppressants, chemotherapy) Pierre BIOPSY REPORT > Well, I finally got a copy of my sons biopsy report, I was wondering if > anyone can make sense > of this for me. I am sorry it is so long, but I would really appreciate > any feed back to better understand this disease. > > Final Diagnosis- renal biopsy with crescentic glomreulonephritis withiga > predominant glomerular immune deposits consistent with iga immune complex > disease. > > Note: The biopsy contains 28 glomeruli adn 12 have segmental celluar ro > fibrocellular crescents. The remaining glomeruli have segmental > endocapillary porliferative changes with capillary basement membrane > reduplication, neutrophilic infiltrates and mesangial cell proliferation. > There is patchy intestinal fibrosis and renal tubular atrophy involving up > to 15% of the biospy. There is a spares mixed cellular interstitial > infiltrate. The renal blood vessels are unremarkable. Immunofluorescent > studies reveal predominant glomerular deposits of IGA and deposits of C3. > Electron microscopic analysis reveals electron dense deposits in > mesangial, subendothelial and intramembranous locations. There is > segmental basement membrane reduplication and mesangial cells > interposition. There is segmental epithelial cell foot proces fusion. > > In summary this is a crescentic glomerulonephritis of IGA etiology. > Clinical correlation should consider HS purpura and IGA nephropathy. > > Immunoflourescence reveal the following findings: glomeruli and > interstitium tubules, vessels > > IgG (2) negative > IgA (2) 1+ to 2+, diffuse, global, granular stainging in the mesangium > and Negative. > in some cappillary walls, with a segmental, peripheral capillary wall > pattern. > > IgM (2) trace +, diffuse, global, granular staining in the mesangium and > Negative. In some capillary walls, with a gegmental, jperipheral > capillary wall pattern. > > C3 (2) Trace + to 1+ diffuse, global, granular staining in the meseangium > +, granular staining in some vessel walls, and in some ca pillary walls, > with a segmental, peripheral capillary wall pattern. > > C4 (2) negative > Clq (1) negative > Fibrinogen (1) faint trace + to trace+, global, granular to irregular > staining Negative. > in the mesangium and in some capillary walls. > > Kappa immunoglobulin light chains (2) Faint trace+ to trace+, diffuse, > negatie. global, granular staining in the mesangium and in some capillary > walls, with a segmental, peripheral capillary wall pattern. > To edit your settings for the group, go to our Yahoo Group home page: http://groups.yahoo.com/group/iga-nephropathy/ To unsubcribe via email, iga-nephropathy-unsubscribe Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: http://www.igan.ca/id62.htm Thank you --------------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 Irma, I will keep you in my prayers. Hugs nne Breast Cancer Patients Soul Mates for Life http://www.geocities.com/chucky5741/breastcancerpatients.html BreastCancerStories.com http://www.breastcancerstories.com/content/view/433/161/ Angel Feather Loomer www.angelfeatherloomer.blogspot.com Check out my other ornaments at www.geocities.com/chucky5741/bcornament.html Lots of info and gifts at: www.cancerclub.com Biopsy Report Hi Everyone, I am scheduled for surgery on Thurs. 10/12. I received the diagnosis on 9/25 that I have IDC Grade 3(Total score 8 poorly differentiated). The Dr. went over the biopsy report but of course I was in such despair I didnt even concentrate on his words. He gave me a copy and I researched the info. I am seeing him Monday to go over the MRI findings, my surgery and the removal of my lymph nodes. I do have some questions that I hope someone can answer. I want to go in on Monday with a full understanding of what to ask. Here are the findings I'm not clear on: 1) HER-2-Neu 2+/positive 2) Receptor status-ER 90% PR 95% 3) K167 approx 50% of tumor cells stained positive Again thank you for the support you have given me! God Bless, Irma __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 Thank you nne. I am do glad I joined this group because I don't feel alone anymore. --- & nne Svihlik wrote: > Irma, > I will keep you in my prayers. > Hugs > nne > Breast Cancer Patients Soul Mates for Life > http://www.geocities.com/chucky5741/breastcancerpatients.html > BreastCancerStories.com > http://www.breastcancerstories.com/content/view/433/161/ > Angel Feather Loomer > www.angelfeatherloomer.blogspot.com > Check out my other ornaments at > www.geocities.com/chucky5741/bcornament.html > Lots of info and gifts at: > www.cancerclub.com > Biopsy Report > > > Hi Everyone, > > I am scheduled for surgery on Thurs. 10/12. I > received > the diagnosis on 9/25 that I have IDC Grade > 3(Total > score 8 poorly differentiated). The Dr. went over > the > biopsy report but of course I was in such despair > I > didnt even concentrate on his words. He gave me a > copy > and I researched the info. I am seeing him Monday > to > go over the MRI findings, my surgery and the > removal > of my lymph nodes. I do have some questions that I > hope someone can answer. I want to go in on Monday > with a full understanding of what to ask. Here are > the > findings I'm not clear on: > > 1) HER-2-Neu 2+/positive > 2) Receptor status-ER 90% PR 95% > 3) K167 approx 50% of tumor cells stained positive > > Again thank you for the support you have given me! > > God Bless, > Irma > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 Irma, 1. Sounds as though you are a weak positive by IHC testing. Ask the doc about doing a FISH test which is more accurate. If you are truely positive, Herceptin may be an option, but be sure to research it. Her2 positive can mean a more agressive cancer. I am Her 2 positive by FISH. Was a weak positive by IHC so insisted on FISH testing 2. You are very estrogen and progesterone positive. In other words your cancer feeds on estrogen which would make you a candidate for aromatase inhibitors, which prevent your body from converting androgens to estrogen. I am estrogen positive, 70 to 100% but only 1 to 11% positive on the progesterone end. 3. Afraid I can't help you with this one. I believe it is another marker indicating how agressive the cancer is. You might want to try Googleing it. Ruth > > Hi Everyone, > > I am scheduled for surgery on Thurs. 10/12. I received > the diagnosis on 9/25 that I have IDC Grade 3(Total > score 8 poorly differentiated). The Dr. went over the > biopsy report but of course I was in such despair I > didnt even concentrate on his words. He gave me a copy > and I researched the info. I am seeing him Monday to > go over the MRI findings, my surgery and the removal > of my lymph nodes. I do have some questions that I > hope someone can answer. I want to go in on Monday > with a full understanding of what to ask. Here are the > findings I'm not clear on: > > 1) HER-2-Neu 2+/positive > 2) Receptor status-ER 90% PR 95% > 3) K167 approx 50% of tumor cells stained positive > > Again thank you for the support you have given me! > > God Bless, > Irma > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 Hi Ruth, What does IHC stand for? I appreciate your response to my question. Thank you. --- ruthiema36 wrote: > Irma, > 1. Sounds as though you are a weak positive by IHC > testing. Ask the > doc about doing a FISH test which is more accurate. > If you are truely > positive, Herceptin may be an option, but be sure to > research it. > Her2 positive can mean a more agressive cancer. I > am Her 2 positive > by FISH. Was a weak positive by IHC so insisted on > FISH testing > 2. You are very estrogen and progesterone positive. > In other words > your cancer feeds on estrogen which would make you a > candidate for > aromatase inhibitors, which prevent your body from > converting > androgens to estrogen. I am estrogen positive, 70 > to 100% but only 1 > to 11% positive on the progesterone end. > 3. Afraid I can't help you with this one. I > believe it is another > marker indicating how agressive the cancer is. You > might want to try > Googleing it. > Ruth > > > > > > Hi Everyone, > > > > I am scheduled for surgery on Thurs. 10/12. I > received > > the diagnosis on 9/25 that I have IDC Grade > 3(Total > > score 8 poorly differentiated). The Dr. went over > the > > biopsy report but of course I was in such despair > I > > didnt even concentrate on his words. He gave me a > copy > > and I researched the info. I am seeing him Monday > to > > go over the MRI findings, my surgery and the > removal > > of my lymph nodes. I do have some questions that I > > hope someone can answer. I want to go in on Monday > > with a full understanding of what to ask. Here are > the > > findings I'm not clear on: > > > > 1) HER-2-Neu 2+/positive > > 2) Receptor status-ER 90% PR 95% > > 3) K167 approx 50% of tumor cells stained positive > > > > Again thank you for the support you have given me! > > > > God Bless, > > Irma > > > > __________________________________________________ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 Hi Irma, IHC stands for Immunohistochemistry. Here is an exerpt from a website on questions and answers for Her2 testing. Q. Which HER2 tests are FDA approved to select patients for treatment with Herceptin? A: There are two FDA-approved tests to determine HER2 status and select patients for treatment with Herceptin. The first approved was an immunohistochemistry (IHC) test (DAKO HercepTest®), which measures the level of expression of the HER2 protein.(1) In HER2-positive tumors, there is an excess amount of the HER2 protein on the cell surface. This is referred to as HER2 overexpression. A more recently approved method, FISH (fluorescence in situ hybridization) (Vysis PathVysion®), detects the underlying gene alteration in the patient's tumor cells. FISH measures the number of HER2/neu gene copies.(1) In HER2-positive tumors, there are 2 or more copies of the HER2/neu gene per chromosome 17, i.e., there is gene amplification of HER2/neu.(6) http://www.herceptin.com/herceptin/professional/testing/faqs.jsp#q2 Hope this helps. Breast cancer is certainly an education in and of itself. I think I am ready for my medical boards! Ruth > > > > > > Hi Everyone, > > > > > > I am scheduled for surgery on Thurs. 10/12. I > > received > > > the diagnosis on 9/25 that I have IDC Grade > > 3(Total > > > score 8 poorly differentiated). The Dr. went over > > the > > > biopsy report but of course I was in such despair > > I > > > didnt even concentrate on his words. He gave me a > > copy > > > and I researched the info. I am seeing him Monday > > to > > > go over the MRI findings, my surgery and the > > removal > > > of my lymph nodes. I do have some questions that I > > > hope someone can answer. I want to go in on Monday > > > with a full understanding of what to ask. Here are > > the > > > findings I'm not clear on: > > > > > > 1) HER-2-Neu 2+/positive > > > 2) Receptor status-ER 90% PR 95% > > > 3) K167 approx 50% of tumor cells stained positive > > > > > > Again thank you for the support you have given me! > > > > > > God Bless, > > > Irma > > > > > > __________________________________________________ > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2006 Report Share Posted October 7, 2006 Thank you Ruth! Yes I do agree, you are ready for the medical boards!! --- ruthiema36 wrote: > Hi Irma, > IHC stands for Immunohistochemistry. Here is an > exerpt from a website > on questions and answers for Her2 testing. > > Q. Which HER2 tests are FDA approved to select > patients for treatment > with Herceptin? > A: There are two FDA-approved tests to determine > HER2 status and > select patients for treatment with Herceptin. The > first approved was > an immunohistochemistry (IHC) test (DAKO > HercepTest®), which measures > the level of expression of the HER2 protein.(1) In > HER2-positive > tumors, there is an excess amount of the HER2 > protein on the cell > surface. This is referred to as HER2 overexpression. > A more recently > approved method, FISH (fluorescence in situ > hybridization) (Vysis > PathVysion®), detects the underlying gene alteration > in the patient's > tumor cells. FISH measures the number of HER2/neu > gene copies.(1) In > HER2-positive tumors, there are 2 or more copies of > the HER2/neu gene > per chromosome 17, i.e., there is gene amplification > of HER2/neu.(6) > http://www.herceptin.com/herceptin/professional/testing/faqs.jsp#q2 > > > Hope this helps. Breast cancer is certainly an > education in and of > itself. I think I am ready for my medical boards! > Ruth > > > > > > > > > > Hi Everyone, > > > > > > > > I am scheduled for surgery on Thurs. 10/12. I > > > received > > > > the diagnosis on 9/25 that I have IDC Grade > > > 3(Total > > > > score 8 poorly differentiated). The Dr. went > over > > > the > > > > biopsy report but of course I was in such > despair > > > I > > > > didnt even concentrate on his words. He gave > me a > > > copy > > > > and I researched the info. I am seeing him > Monday > > > to > > > > go over the MRI findings, my surgery and the > > > removal > > > > of my lymph nodes. I do have some questions > that I > > > > hope someone can answer. I want to go in on > Monday > > > > with a full understanding of what to ask. Here > are > > > the > > > > findings I'm not clear on: > > > > > > > > 1) HER-2-Neu 2+/positive > > > > 2) Receptor status-ER 90% PR 95% > > > > 3) K167 approx 50% of tumor cells stained > positive > > > > > > > > Again thank you for the support you have given > me! > > > > > > > > God Bless, > > > > Irma > > > > > > > > > __________________________________________________ > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 8, 2006 Report Share Posted October 8, 2006 Hi Irma, My mother had HER+ type of cancer. She finished lumpectomy (bilateral on both breasts), followed by chemo & radiation last month. For HER patients, a medicine called Transtuzumab will be given. But in my mother's case, they did'nt give it mostly because of less effect of the drug and more side effects.(This is what the doctors say). Would you pls tell me if your doctor is giving you Transtuzumab for HER. She took her treatment in India. I understand that in other countries the patients are given this medicine for HER+ and I do not understand why they are not following the same protocol in India? If you get any information reg. this medicine, pls. pass it to me. You are there always in my prayers. I know how cancer devastates you and your loved ones. But be positive and always believe inside that you will fight and drive this disease from you. Life is a challenge, face the challenge. You have more things to achieve and accomplish in life. I always pray to God to find a good drug that fight against BC and other forms of cancer. Take care and smile even in your deepest pain. Let God see your painful smile. Love and Hugs/Sophia from Dubai. Irma Cunarro wrote: Thank you nne. I am do glad I joined this group because I don't feel alone anymore. --- & nne Svihlik wrote: > Irma, > I will keep you in my prayers. > Hugs > nne > Breast Cancer Patients Soul Mates for Life > http://www.geocities.com/chucky5741/breastcancerpatients.html > BreastCancerStories.com > http://www.breastcancerstories.com/content/view/433/161/ > Angel Feather Loomer > www.angelfeatherloomer.blogspot.com > Check out my other ornaments at > www.geocities.com/chucky5741/bcornament.html > Lots of info and gifts at: > www.cancerclub.com > Biopsy Report > > > Hi Everyone, > > I am scheduled for surgery on Thurs. 10/12. I > received > the diagnosis on 9/25 that I have IDC Grade > 3(Total > score 8 poorly differentiated). The Dr. went over > the > biopsy report but of course I was in such despair > I > didnt even concentrate on his words. He gave me a > copy > and I researched the info. I am seeing him Monday > to > go over the MRI findings, my surgery and the > removal > of my lymph nodes. I do have some questions that I > hope someone can answer. I want to go in on Monday > with a full understanding of what to ask. Here are > the > findings I'm not clear on: > > 1) HER-2-Neu 2+/positive > 2) Receptor status-ER 90% PR 95% > 3) K167 approx 50% of tumor cells stained positive > > Again thank you for the support you have given me! > > God Bless, > Irma > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2006 Report Share Posted October 9, 2006 Hi Sophia, Transtuzumab (Herceptin) is standard now in the US for HER2+ women. If a woman is very early stage 1, it may not be given. Also, if she is early stage and ER/PR+, then it may not be given, because she has other treatment options. I know that England & Australia were later in getting it approved for early stage women. It is an expensive drug, so I'm afraid that's why it is hard to get it approved. You can point out studies to your doctor that show Herceptin is very effective for HER2+ woman, and has less side effects than chemotherapy. My Internet is not functioning well now, but I would think the studies would be available from herceptin.com, her2support.org, or breastcancer.org. take care, Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.