Re: Hip Hip Hooray!/Lipo Glut and Memory?

[Guest guest]

,

I did a quick google search on glutathione and memory loss, and it

gave me lots of articles like this one, explaining how glutathione

is important for memory:

" Normally - and especially when we're young - the brain's natural

antioxidant defense system repels the onslaught of free radicals,

minimizing oxidative stress and helping to keep our memory and other

faculties sharp. The chief defender here is glutathione, the body's

most abundant and most important antioxidant. (Glutathione cannot be

taken as a supplement, by the way, because it breaks down in the

digestive tract.) As we age, however - and what a familiar refrain

this is - the antioxidant system gradually weakens and deteriorates,

becoming ever less productive and efficient. The result is . . .

uh . . . well, I've forgotten, but I know it's not good. "

It's very intriguing that Tanner would have the opposite reaction

from what is expected, especially since his body shouldn't have been

absorbing it at all! Here's a little info from www.gshnow.com,

where I get my lipo glut:

" Lipoceutical Glutathione is a liposomal glutathione supplement in

liquid form.

The powerful antioxidant glutathione is contained in tiny nanosize

spheres called liposomes. When taken orally, liposomes are absorbed

readily into the body.

You would need a microscope to see a single liposome, but you can

see the cluster of them when a small amount is added to water.

DOES NOT NEED REFRIGERATION! Click for details.

WHEN TAKEN ORALLY BY ITSELF, GLUTATHIONE IS NOT ABSORBED INTO THE

BODY. "

So in order to get the glutathione into the body, you need to use

another form - either liposomal, transdermal, subcutaneous - or use

a precursor such as taurine or methionine.

As the for surge on the lipo glut, like I said she started using f,

s, w, v, z, h at the beginning of words and using s-ending for

plurals even though neither of her therapists has even touched on

these sounds. It really increased her intelligibility, and her

therapists were very impressed. She basically became a little

less " apraxic " . It was like a big fish oil surge, except for one

big thing - if the lipo glut worked the way it " should " have, that

means she saw increases because her body was able to rid itself of

toxins and/or heavy metals from her brain, not because she

temporarily remyelinated with fish oil. My opinion is that she has

heavy metals and viruses hanging out in her brain that need to be

removed in order for her to make a full recovery, and no amount of

fish oil is going to do that. She's been off lipo glut for almost 2

weeks now, and there's been no regression.

Kerri

>

> Kerri the archives are so awesome -just a wealth of information to

> all of us at our fingertips to search. It is wonderful to be able

> to look back at what you wrote from the first email and see just

how

> far your child has come.

>

> In Tanner like I said he did report it helped his speech. How

well

> is your child speaking? Tanner is at the point where each week we

> work on studying for tests in the car as I drive him to school.

He

> could have a list of 12 spelling words with words like porcelain

and

> not only know how to spell all of them by the first or second day -

> but would have the list memorized that quickly too. We call him

> memory head. He's been like that as long as I can recall.

>

> 5 days after glutathione he not only couldn't remember the

> list, but how to spell them even if I told him. He kept

> saying " What is that again? " I was really scared. What I posted

> here is that if I was not fully aware of Tanner's memory and if he

> wasn't speaking as well as he was and doing so well in school -I'm

> not sure I would have noticed this. I was terrified I did

something

> to Tanner and prayed that if I stopped his memory would come

back.

> Over the next few days gradually it did.

>

> Of course I used the wrong stuff. I used the powder glutathione.

> What's the difference again?

>

> So the ten million dollar question is would you say in the past 2

> weeks your child's had that much of a surge? Where was he prior

> to two weeks ago and what exactly did you see since?!

>

> And...how did it compare to the fish oils surges you've seen?

>

> =====

>

[Guest guest]

The issue is also " reduced " vs " oxidized " glutathione. When the body or

certain organs in the body loose the ability to reduce glutathione there is

an accumulation of oxidized glutathione - which adds to oxidative stress and

has a cascade of its own events that could be harmful. The trick is to

increase the amount of reduced glutathione (GSH) - which acts as a very

important antioxidant. Maybe that is what liposomal glutathione supplements

do - I don't know enough about it yet. But if the supplements lead to an

increase in oxidized glutathione - there could be adverse events...makes me

wonder if that is what was seeing in Tanner? But it is really very

interesting.

There are other ways to increase GSH levels - like N-acetyl-cysteine...its

the treatment for tylenol overdose. I don't know if that's ever been looked

at in autism - sure its not been investigated in apraxia, & I haven't had

time to look. Basically what puts someone into liver failure from tylenol is

consumption of glutathione in the liver. Also makes me wonder whether

tylenol may be a bad thing for kids with GSH deficiency (often seen in

autism). GSH levels are low in many conditions of inflammation - including

asthma, and depletion of GSH is a key pathway in the aging process. I just

gave a talk based on research I've been doing that demonstrates a very

strong association between depletion of GSH in the red blood cell and

severity of pulmonary hypertension in patients with sickle cell disease. It

is very intriguing that most of these patients have severe impairment of

cognitive function on many levels - attention, communication, memory. Much

has been attributed over the years to " silent strokes " - but I'm starting to

wonder from all I'm learning about apraxia and autism where there is some

metabolic link. Funny - I just found a small study that demonstrated that

omega 3 supplements decreased oxidative stress in sickle cell. There is so

much overlap among these inflammatory conditions. -

[ ] Re: Hip Hip Hooray!/Lipo Glut and Memory?

,

I did a quick google search on glutathione and memory loss, and it

gave me lots of articles like this one, explaining how glutathione

is important for memory:

" Normally - and especially when we're young - the brain's natural

antioxidant defense system repels the onslaught of free radicals,

minimizing oxidative stress and helping to keep our memory and other

faculties sharp. The chief defender here is glutathione, the body's

most abundant and most important antioxidant. (Glutathione cannot be

taken as a supplement, by the way, because it breaks down in the

digestive tract.) As we age, however - and what a familiar refrain

this is - the antioxidant system gradually weakens and deteriorates,

becoming ever less productive and efficient. The result is . . .

uh . . . well, I've forgotten, but I know it's not good. "

It's very intriguing that Tanner would have the opposite reaction

from what is expected, especially since his body shouldn't have been

absorbing it at all! Here's a little info from www.gshnow.com,

where I get my lipo glut:

" Lipoceutical Glutathione is a liposomal glutathione supplement in

liquid form.

The powerful antioxidant glutathione is contained in tiny nanosize

spheres called liposomes. When taken orally, liposomes are absorbed

readily into the body.

You would need a microscope to see a single liposome, but you can

see the cluster of them when a small amount is added to water.

DOES NOT NEED REFRIGERATION! Click for details.

WHEN TAKEN ORALLY BY ITSELF, GLUTATHIONE IS NOT ABSORBED INTO THE

BODY. "

So in order to get the glutathione into the body, you need to use

another form - either liposomal, transdermal, subcutaneous - or use

a precursor such as taurine or methionine.

As the for surge on the lipo glut, like I said she started using f,

s, w, v, z, h at the beginning of words and using s-ending for

plurals even though neither of her therapists has even touched on

these sounds. It really increased her intelligibility, and her

therapists were very impressed. She basically became a little

less " apraxic " . It was like a big fish oil surge, except for one

big thing - if the lipo glut worked the way it " should " have, that

means she saw increases because her body was able to rid itself of

toxins and/or heavy metals from her brain, not because she

temporarily remyelinated with fish oil. My opinion is that she has

heavy metals and viruses hanging out in her brain that need to be

removed in order for her to make a full recovery, and no amount of

fish oil is going to do that. She's been off lipo glut for almost 2

weeks now, and there's been no regression.

Kerri

[Guest guest]

Well keeping glutathione in the reduced form requires an adequate

supply of niacin/niacinamide/riboflavin. Usually the inability to get

oral glutatione reduced lies in nutritional

deficiencies/malabsorption. In autism they use the reduced form of

glutathione, but difficulties still arise if you do not have all your

bases covered. Using reduced glutathione on its own as a stand alone

treatment may give limited results,but it is but part of a whole. As

far as N-AC we used that for quite awhile, but that was only because

of low cysteine measurements, once our levels were adequate it was

d/c'd. It is not adviseable to use NAC if you have adequate cysteine

levels. N-AC is used extensively in other developmental delays as

well as autism.

>

> The issue is also " reduced " vs " oxidized " glutathione. When the

body or

> certain organs in the body loose the ability to reduce glutathione

there is

> an accumulation of oxidized glutathione - which adds to oxidative

stress and

> has a cascade of its own events that could be harmful. The trick

is to

> increase the amount of reduced glutathione (GSH) - which acts as a

very

> important antioxidant. Maybe that is what liposomal glutathione

supplements

> do - I don't know enough about it yet. But if the supplements lead

to an

> increase in oxidized glutathione - there could be adverse

events...makes me

> wonder if that is what was seeing in Tanner? But it is really

very

> interesting.

>

> There are other ways to increase GSH levels - like N-acetyl-

cysteine...its

> the treatment for tylenol overdose. I don't know if that's ever

been looked

> at in autism - sure its not been investigated in apraxia, & I

haven't had

> time to look. Basically what puts someone into liver failure from

tylenol is

> consumption of glutathione in the liver. Also makes me wonder

whether

> tylenol may be a bad thing for kids with GSH deficiency (often seen

in

> autism). GSH levels are low in many conditions of inflammation -

including

> asthma, and depletion of GSH is a key pathway in the aging

process. I just

> gave a talk based on research I've been doing that demonstrates a

very

> strong association between depletion of GSH in the red blood cell

and

> severity of pulmonary hypertension in patients with sickle cell

disease. It

> is very intriguing that most of these patients have severe

impairment of

> cognitive function on many levels - attention, communication,

memory. Much

> has been attributed over the years to " silent strokes " - but I'm

starting to

> wonder from all I'm learning about apraxia and autism where there

is some

> metabolic link. Funny - I just found a small study that

demonstrated that

> omega 3 supplements decreased oxidative stress in sickle cell.

There is so

> much overlap among these inflammatory conditions. -

>

[Guest guest]

This is a very interesting thread for me because I just got back my OAT tests

results from

Great Plains Lab this week and one of the things they showed was depleted

glutathione

levels (this is part of my " try everything on me first before trying it with the

kids " policy.

I've just bought some extra vitamin C (buffered) and L-Carnitine and

Acetyl-L-Carnitine

and probiotics, got a test slip to rule out an adrenal tumor although we both

(doctor and I)

agree it's (the very high VMA) probably just stress (wonder why I would be

stressed, LOL?)

and seem to have possibly some mild, maybe heterozygous, incompletely

penetrance-type

fatty acid oxidation metabolism disorder which causes hypoglycemia and lethargy

(extremely high suberic and and ethylmalonic acids, also 3-oxyglutaric high) .

I was going to ignore the latter, or blame it on mercury/pollution poisoning,

but I never

have been able to tolerate either much exercise or high amounts of protein and

my

daughter (the internal medicine vet) says, both she and her son also, have

similar

problems. My daughter's blood sugar one day when she was in vet school, she

felt so

shaky and bad she measured it herself and it was 20--shouldn't even have been

conscious, practically. She is the one who had seizures after the mumps vaccine.

The L-Carnitine should help with the fatty acid oxidation disorder and N-acetyl

L-cysteine,

reducted glutathione, buffered C and lipoic acid are all supposed to raise

increase

glutathione livels, according to GPL.

While I was just going to increase the vitamins, my weight suddenly went up 10

lbs in two

days this week after my gamma globulin infusion and trips to Tampa with the

kids, I have

asthma, and lupus, so I got a Medrol pack (like prednisone) and what do you

know, I feel

much better. (Temporarily.) I guess all this is not totally OT because many

of us on this

list and our children may have similar histories of high chemical exposure (and

I had high

mercury as well in my RBCs for a while anyway). I certainly don't have apraxia

but I have

lots of word retrieval problems. And I'll let you know if any of it seems to be

hereditary

because I think there is a heredity/environmental interaction here.

Peace,

Kathy E.

-- In , " deverelementary " <kearneysix@...>

wrote:

>

> Well keeping glutathione in the reduced form requires an adequate

> supply of niacin/niacinamide/riboflavin. Usually the inability to get

> oral glutatione reduced lies in nutritional

> deficiencies/malabsorption. In autism they use the reduced form of

> glutathione, but difficulties still arise if you do not have all your

> bases covered. Using reduced glutathione on its own as a stand alone

> treatment may give limited results,but it is but part of a whole. As

> far as N-AC we used that for quite awhile, but that was only because

> of low cysteine measurements, once our levels were adequate it was

> d/c'd. It is not adviseable to use NAC if you have adequate cysteine

> levels. N-AC is used extensively in other developmental delays as

> well as autism.

>

>

>

> >

> > The issue is also " reduced " vs " oxidized " glutathione. When the

> body or

> > certain organs in the body loose the ability to reduce glutathione

> there is

> > an accumulation of oxidized glutathione - which adds to oxidative

> stress and

> > has a cascade of its own events that could be harmful. The trick

> is to

> > increase the amount of reduced glutathione (GSH) - which acts as a

> very

> > important antioxidant. Maybe that is what liposomal glutathione

> supplements

> > do - I don't know enough about it yet. But if the supplements lead

> to an

> > increase in oxidized glutathione - there could be adverse

> events...makes me

> > wonder if that is what was seeing in Tanner? But it is really

> very

> > interesting.

> >

> > There are other ways to increase GSH levels - like N-acetyl-

> cysteine...its

> > the treatment for tylenol overdose. I don't know if that's ever

> been looked

> > at in autism - sure its not been investigated in apraxia, & I

> haven't had

> > time to look. Basically what puts someone into liver failure from

> tylenol is

> > consumption of glutathione in the liver. Also makes me wonder

> whether

> > tylenol may be a bad thing for kids with GSH deficiency (often seen

> in

> > autism). GSH levels are low in many conditions of inflammation -

> including

> > asthma, and depletion of GSH is a key pathway in the aging

> process. I just

> > gave a talk based on research I've been doing that demonstrates a

> very

> > strong association between depletion of GSH in the red blood cell

> and

> > severity of pulmonary hypertension in patients with sickle cell

> disease. It

> > is very intriguing that most of these patients have severe

> impairment of

> > cognitive function on many levels - attention, communication,

> memory. Much

> > has been attributed over the years to " silent strokes " - but I'm

> starting to

> > wonder from all I'm learning about apraxia and autism where there

> is some

> > metabolic link. Funny - I just found a small study that

> demonstrated that

> > omega 3 supplements decreased oxidative stress in sickle cell.

> There is so

> > much overlap among these inflammatory conditions. -

> >

>

[Guest guest]

Kathy,

If you have an intolerance for protein, that could explain the

lethargy/exercise intolerance/low glutathione. If protein intake is

just even in the RDA(for some people) amount your body is using alot

of energy just to breakdown the protein, you will deplete glutathione

and produce higher amounts of ammonia, and that really taxes the kreb

cycle and you get high intermediates on the GPL OAT test. Along with

that an increase int he stress/cortisol response(perhaps the sudden

increase in weight(fluid retention)Just an ideas for you to

ponder.Yes I agree a hereditary component for sure.

>

> This is a very interesting thread for me because I just got back my

OAT tests results from

> Great Plains Lab this week and one of the things they showed was

depleted glutathione

> levels (this is part of my " try everything on me first before

trying it with the kids " policy.

>

> I've just bought some extra vitamin C (buffered) and L-Carnitine

and Acetyl-L-Carnitine

> and probiotics, got a test slip to rule out an adrenal tumor

although we both (doctor and I)

> agree it's (the very high VMA) probably just stress (wonder why I

would be stressed, LOL?)

> and seem to have possibly some mild, maybe heterozygous,

incompletely penetrance-type

> fatty acid oxidation metabolism disorder which causes hypoglycemia

and lethargy

> (extremely high suberic and and ethylmalonic acids, also 3-

oxyglutaric high) .

>

> I was going to ignore the latter, or blame it on mercury/pollution

poisoning, but I never

> have been able to tolerate either much exercise or high amounts of

protein and my

> daughter (the internal medicine vet) says, both she and her son

also, have similar

> problems. My daughter's blood sugar one day when she was in vet

school, she felt so

> shaky and bad she measured it herself and it was 20--shouldn't even

have been

> conscious, practically. She is the one who had seizures after the

mumps vaccine.

>

> The L-Carnitine should help with the fatty acid oxidation disorder

and N-acetyl L-cysteine,

> reducted glutathione, buffered C and lipoic acid are all supposed

to raise increase

> glutathione livels, according to GPL.

>

> While I was just going to increase the vitamins, my weight suddenly

went up 10 lbs in two

> days this week after my gamma globulin infusion and trips to Tampa

with the kids, I have

> asthma, and lupus, so I got a Medrol pack (like prednisone) and

what do you know, I feel

> much better. (Temporarily.) I guess all this is not totally OT

because many of us on this

> list and our children may have similar histories of high chemical

exposure (and I had high

> mercury as well in my RBCs for a while anyway). I certainly don't

have apraxia but I have

> lots of word retrieval problems. And I'll let you know if any of

it seems to be hereditary

> because I think there is a heredity/environmental interaction

here.

>

> Peace,

> Kathy E.

[Guest guest]

That low glucose should certainly be worked up by either an endocrinologist

or metabolic specialist. There are hereditary metabolic syndromes associated

with low glucose...as I'm sure you probably know. They are rare, but exist.

Hypogycemia can occur after long periods of sleep in some cases - or after

stress/during infections - and certainly can cause a seizure. So the

seizure after the vaccine could have been hypoglycemia-triggered and totally

unrelated to mercury. Your daughter definitely needs to get it evaluated as

well. The next time she goes down to 20 - she may just wind up unconscious.

Its hard to find a good metabolic specialist - usually need to go to the big

centers like Mayo, Yale, Harvard or Stanford etc.

[ ] Re: Hip Hip Hooray!/Lipo Glut and Memory?

This is a very interesting thread for me because I just got back my OAT

tests results from

Great Plains Lab this week and one of the things they showed was depleted

glutathione

levels (this is part of my " try everything on me first before trying it with

the kids " policy.

I've just bought some extra vitamin C (buffered) and L-Carnitine and

Acetyl-L-Carnitine

and probiotics, got a test slip to rule out an adrenal tumor although we

both (doctor and I)

agree it's (the very high VMA) probably just stress (wonder why I would be

stressed, LOL?)

and seem to have possibly some mild, maybe heterozygous, incompletely

penetrance-type

fatty acid oxidation metabolism disorder which causes hypoglycemia and

lethargy

(extremely high suberic and and ethylmalonic acids, also 3-oxyglutaric high)

..

I was going to ignore the latter, or blame it on mercury/pollution

poisoning, but I never

have been able to tolerate either much exercise or high amounts of protein

and my

daughter (the internal medicine vet) says, both she and her son also, have

similar

problems. My daughter's blood sugar one day when she was in vet school, she

felt so

shaky and bad she measured it herself and it was 20--shouldn't even have

been

conscious, practically. She is the one who had seizures after the mumps

vaccine.

The L-Carnitine should help with the fatty acid oxidation disorder and

N-acetyl L-cysteine,

reducted glutathione, buffered C and lipoic acid are all supposed to raise

increase

glutathione livels, according to GPL.

While I was just going to increase the vitamins, my weight suddenly went up

10 lbs in two

days this week after my gamma globulin infusion and trips to Tampa with the

kids, I have

asthma, and lupus, so I got a Medrol pack (like prednisone) and what do you

know, I feel

much better. (Temporarily.) I guess all this is not totally OT because

many of us on this

list and our children may have similar histories of high chemical exposure

(and I had high

mercury as well in my RBCs for a while anyway). I certainly don't have

apraxia but I have

lots of word retrieval problems. And I'll let you know if any of it seems

to be hereditary

because I think there is a heredity/environmental interaction here.

Peace,

Kathy E.

[Guest guest]

Also in situations of increased inflammation (or " oxidative

stress " )...glutathione gets consumed. It is such a complex pathway that its

hard to identify any one part of it to explain the whole. Often the supply

of niacin/riboflavin is also depleted to keep up - this is very true. So in

these individuals a higher than typical daily requirement is needed to meet

demands. So not always a " nutritional deficiency " per say - one can have a

completely sound diet but not meet demands due to whatever inflammatory

state that uses up the natural antioxidants quickly. Bearing this in

mind...a little extra vitamin E is probably a good thing in that situation -

for those posing the question on vit E. -

[ ] Re: Hip Hip Hooray!/Lipo Glut and Memory?

Well keeping glutathione in the reduced form requires an adequate

supply of niacin/niacinamide/riboflavin. Usually the inability to get

oral glutatione reduced lies in nutritional

deficiencies/malabsorption. In autism they use the reduced form of

glutathione, but difficulties still arise if you do not have all your

bases covered. Using reduced glutathione on its own as a stand alone

treatment may give limited results,but it is but part of a whole. As

far as N-AC we used that for quite awhile, but that was only because

of low cysteine measurements, once our levels were adequate it was

d/c'd. It is not adviseable to use NAC if you have adequate cysteine

levels. N-AC is used extensively in other developmental delays as

well as autism.

>

> The issue is also " reduced " vs " oxidized " glutathione. When the

body or

> certain organs in the body loose the ability to reduce glutathione

there is

> an accumulation of oxidized glutathione - which adds to oxidative

stress and

> has a cascade of its own events that could be harmful. The trick

is to

> increase the amount of reduced glutathione (GSH) - which acts as a

very

> important antioxidant. Maybe that is what liposomal glutathione

supplements

> do - I don't know enough about it yet. But if the supplements lead

to an

> increase in oxidized glutathione - there could be adverse

events...makes me

> wonder if that is what was seeing in Tanner? But it is really

very

> interesting.

>

> There are other ways to increase GSH levels - like N-acetyl-

cysteine...its

> the treatment for tylenol overdose. I don't know if that's ever

been looked

> at in autism - sure its not been investigated in apraxia, & I

haven't had

> time to look. Basically what puts someone into liver failure from

tylenol is

> consumption of glutathione in the liver. Also makes me wonder

whether

> tylenol may be a bad thing for kids with GSH deficiency (often seen

in

> autism). GSH levels are low in many conditions of inflammation -

including

> asthma, and depletion of GSH is a key pathway in the aging

process. I just

> gave a talk based on research I've been doing that demonstrates a

very

> strong association between depletion of GSH in the red blood cell

and

> severity of pulmonary hypertension in patients with sickle cell

disease. It

> is very intriguing that most of these patients have severe

impairment of

> cognitive function on many levels - attention, communication,

memory. Much

> has been attributed over the years to " silent strokes " - but I'm

starting to

> wonder from all I'm learning about apraxia and autism where there

is some

> metabolic link. Funny - I just found a small study that

demonstrated that

> omega 3 supplements decreased oxidative stress in sickle cell.

There is so

> much overlap among these inflammatory conditions. -

>

[Guest guest]

Did you use NAC in oral form, or transdermal? Does oral NAC tend to

cause yeast flareups? We are considering a change from liposomal glut

since yeast is still a recurring problem for my kids.

thanks,

> >

> > The issue is also " reduced " vs " oxidized " glutathione. When the

> body or

> > certain organs in the body loose the ability to reduce glutathione

> there is

> > an accumulation of oxidized glutathione - which adds to oxidative

> stress and

> > has a cascade of its own events that could be harmful. The trick

> is to

> > increase the amount of reduced glutathione (GSH) - which acts as a

> very

> > important antioxidant. Maybe that is what liposomal glutathione

> supplements

> > do - I don't know enough about it yet. But if the supplements lead

> to an

> > increase in oxidized glutathione - there could be adverse

> events...makes me

> > wonder if that is what was seeing in Tanner? But it is really

> very

> > interesting.

> >

> > There are other ways to increase GSH levels - like N-acetyl-

> cysteine...its

> > the treatment for tylenol overdose. I don't know if that's ever

> been looked

> > at in autism - sure its not been investigated in apraxia, & I

> haven't had

> > time to look. Basically what puts someone into liver failure from

> tylenol is

> > consumption of glutathione in the liver. Also makes me wonder

> whether

> > tylenol may be a bad thing for kids with GSH deficiency (often seen

> in

> > autism). GSH levels are low in many conditions of inflammation -

> including

> > asthma, and depletion of GSH is a key pathway in the aging

> process. I just

> > gave a talk based on research I've been doing that demonstrates a

> very

> > strong association between depletion of GSH in the red blood cell

> and

> > severity of pulmonary hypertension in patients with sickle cell

> disease. It

> > is very intriguing that most of these patients have severe

> impairment of

> > cognitive function on many levels - attention, communication,

> memory. Much

> > has been attributed over the years to " silent strokes " - but I'm

> starting to

> > wonder from all I'm learning about apraxia and autism where there

> is some

> > metabolic link. Funny - I just found a small study that

> demonstrated that

> > omega 3 supplements decreased oxidative stress in sickle cell.

> There is so

> > much overlap among these inflammatory conditions. -

> >

>

[Guest guest]

> >

> > The issue is also " reduced " vs " oxidized " glutathione. When the

> body or

> > certain organs in the body loose the ability to reduce glutathione

> there is

> > an accumulation of oxidized glutathione - which adds to oxidative

> stress and

> > has a cascade of its own events that could be harmful. The trick

> is to

> > increase the amount of reduced glutathione (GSH) - which acts as a

> very

> > important antioxidant. Maybe that is what liposomal glutathione

> supplements

> > do - I don't know enough about it yet. But if the supplements lead

> to an

> > increase in oxidized glutathione - there could be adverse

> events...makes me

> > wonder if that is what was seeing in Tanner? But it is really

> very

> > interesting.

> >

> > There are other ways to increase GSH levels - like N-acetyl-

> cysteine...its

> > the treatment for tylenol overdose. I don't know if that's ever

> been looked

> > at in autism - sure its not been investigated in apraxia, & I

> haven't had

> > time to look. Basically what puts someone into liver failure from

> tylenol is

> > consumption of glutathione in the liver. Also makes me wonder

> whether

> > tylenol may be a bad thing for kids with GSH deficiency (often seen

> in

> > autism). GSH levels are low in many conditions of inflammation -

> including

> > asthma, and depletion of GSH is a key pathway in the aging

> process. I just

> > gave a talk based on research I've been doing that demonstrates a

> very

> > strong association between depletion of GSH in the red blood cell

> and

> > severity of pulmonary hypertension in patients with sickle cell

> disease. It

> > is very intriguing that most of these patients have severe

> impairment of

> > cognitive function on many levels - attention, communication,

> memory. Much

> > has been attributed over the years to " silent strokes " - but I'm

> starting to

> > wonder from all I'm learning about apraxia and autism where there

> is some

> > metabolic link. Funny - I just found a small study that

> demonstrated that

> > omega 3 supplements decreased oxidative stress in sickle cell.

> There is so

> > much overlap among these inflammatory conditions. -

> >

>

--- End forwarded message ---