10 X'S More nerve prolieration w. vestibulitis.

[Guest guest]

To continue in that vein of the nerves. Hope this isn't boring.

Dee~

Gynecol Obstet Invest. 2004 Nov 11;59(2):75-79 [pub ahead of print]

The Major Histopathologic Characteristics in the Vulvar Vestibulitis Syndrome.Halperin R, Zehavi S, Vaknin Z, Ben-Ami I, Pansky M, Schneider D.Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin (affiliated with Sackler School of Medicine, Tel Aviv University), Israel.Objective: In order to better understand the etiology of the vulvar vestibulitis syndrome, we examined the histopathologic parameters in vestibular mucosa, and compared the findings in specimens obtained from women with vulvar vestibulitis with those obtained from the control group.

Study Design:

Specimens of vestibulitis were obtained from 24 patients, undergoing circumferential vestibulectomy under general anesthesia due to the symptoms and signs consistent with vulvar vestibulitis.

Control specimens were obtained from 16 women, without symptoms or signs of vulvar vestibulitis, undergoing reconstructive introital surgery due to roomy vagina, rectocele or painful episiotomy.

All vestibular tissue specimens were examined for intensity of inflammation, extension of inflammatory cells into the epithelium, vascular proliferation, the presence of mast cells and proliferation of peripheral nerve bundles.

Results: No significant difference was found regarding the degree of inflammation, the extension of inflammatory cells into the epithelium, the vascular proliferation and the presence of mast cells while comparing the study and the control groups.

The only histopathologic feature, differentiating the patients with vulvar vestibulitis from the control group, was the proliferation of peripheral nerve bundles found in 19 out of 24 (79.1%) specimens expressing vestibulitis and in none of 16 control specimens (p < 0.0001).

Conclusion: Our results, therefore, support the existence of peripheral nerve hyperplasia in vestibular tissue obtained from patients with vulvar vestibulitis, and exclude the role of active inflammation or mast cells as probable etiologies (cause) for the vulvar vestibulitis syndrome. Copyright © 2005 S. Karger AG, Basel.PMID: 15542936 [PubMed - as supplied by publisher]

Dee here ** On first thought, I personally disagreed with the very last sentence, only because even though there may be that 'excess' of nerve bundles, the hyperplasia itself means it's an overactive or an increase of normal cells that are being irritated or inflammed.... and that to me, 'is' caused by Mast cell granulation, histamine, basophiles, et al, .

On the other hand.... is it saying that having that abnormal increase of nerves is the likely cause.... ?? and it's NOT that they're irritated or inflamed just that there are too many to begin with? But does that not mean 'also' more Mast cells etc? ummm in a quandry here.

This is why I wonder, & is what Bornstein et al, said in his earlier July '04 paper in discussing the same increase in nerve fibers ..

''A significant positive correlation was found between the total nerve fiber area 'and' the number of mast cells in the vestibulitis group of patients.''

CONCLUSION: We documented two diagnostic histopathological criteria for vestibulitis: (1) the presence of eight or more mast cells per 10 x 10 microscopic field, and (2) the total calculated area of the nerve fibers is ten times higher than expected. These findings re-establish the inflammatory nature of the vestibulitis.

Regardless, they're fairly certain those with V vestibulitis do have an overabundance of those nerve endings.

Dee~

Source for top article:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15542936

[Guest guest]

Dee,

For you then, with the estrogen helping so much, did you have nerve

proliferation?

I don't have pain on entry, just burning and general irritation at my vaginal

opening and

vulvar skin.

Thanks for all this info.

>

> To continue in that vein of the nerves. Hope this isn't boring.

>

> Dee~

>

> Gynecol Obstet Invest. 2004 Nov 11;59(2):75-79 [pub ahead of print]

>

> The Major Histopathologic Characteristics in the Vulvar Vestibulitis Syndrome.

>

> Halperin R, Zehavi S, Vaknin Z, Ben-Ami I, Pansky M, Schneider D.

>

> Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin

(affiliated with Sackler School of Medicine, Tel Aviv University), Israel.

>

> Objective: In order to better understand the etiology of the vulvar

vestibulitis syndrome,

we examined the histopathologic parameters in vestibular mucosa, and compared

the

findings in specimens obtained from women with vulvar vestibulitis with those

obtained

from the control group.

>

> Study Design:

>

> Specimens of vestibulitis were obtained from 24 patients, undergoing

circumferential

vestibulectomy under general anesthesia due to the symptoms and signs consistent

with

vulvar vestibulitis.

>

> Control specimens were obtained from 16 women, without symptoms or signs of

vulvar

vestibulitis, undergoing reconstructive introital surgery due to roomy vagina,

rectocele or

painful episiotomy.

>

> All vestibular tissue specimens were examined for intensity of inflammation,

extension

of inflammatory cells into the epithelium, vascular proliferation, the presence

of mast cells

and proliferation of peripheral nerve bundles.

>

> Results: No significant difference was found regarding the degree of

inflammation, the

extension of inflammatory cells into the epithelium, the vascular proliferation

and the

presence of mast cells while comparing the study and the control groups.

>

> The only histopathologic feature, differentiating the patients with vulvar

vestibulitis

from the control group, was the proliferation of peripheral nerve bundles found

in 19 out

of 24 (79.1%) specimens expressing vestibulitis and in none of 16 control

specimens (p <

0.0001).

>

> Conclusion: Our results, therefore, support the existence of peripheral nerve

hyperplasia

in vestibular tissue obtained from patients with vulvar vestibulitis, and

exclude the role of

active inflammation or mast cells as probable etiologies (cause) for the vulvar

vestibulitis

syndrome. Copyright © 2005 S. Karger AG, Basel.

>

> PMID: 15542936 [PubMed - as supplied by publisher]

> Dee here ** On first thought, I personally disagreed with the very last

sentence, only

because even though there may be that 'excess' of nerve bundles, the hyperplasia

itself

means it's an overactive or an increase of normal cells that are being irritated

or

inflammed.... and that to me, 'is' caused by Mast cell granulation, histamine,

basophiles, et

al, .

>

> On the other hand.... is it saying that having that abnormal increase of

nerves is the

likely cause.... ?? and it's NOT that they're irritated or inflamed just that

there are too

many to begin with? But does that not mean 'also' more Mast cells etc? ummm in

a

quandry here.

>

> This is why I wonder, & is what Bornstein et al, said in his earlier July

'04 paper in

discussing the same increase in nerve fibers ..

>

> ''A significant positive correlation was found between the total nerve

fiber area 'and'

the number of mast cells in the vestibulitis group of patients.''

>

> CONCLUSION: We documented two diagnostic histopathological criteria for

vestibulitis: (1) the presence of eight or more mast cells per 10 x 10

microscopic field, and

(2) the total calculated area of the nerve fibers is ten times higher than

expected. These

findings re-establish the inflammatory nature of the vestibulitis.

>

> Regardless, they're fairly certain those with V vestibulitis do have an

overabundance of

those nerve endings.

> Dee~

>

> Source for top article:

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15542936

>