Guest guest Posted February 21, 2002 Report Share Posted February 21, 2002 Here's some more References for the top 20! FROM: Werner and Ingbar’s The Thyroid A Fundamental and Clinical Text, Eighth Edition. Page 703 Hypothyroidism: “Hypothyroidism may be considered an inevitable consequence of RAI therapy, rather than a side effect” This section goes on to state that Hypothyroidism may develop in as many as 90% of patients within the first year after therapy (Ref 243 Cunnien AJ, Hay ID, Gorman CA et al. Radioiodine induced hypothyroidism in Graves’ disease: factors associated with the increasing incidence. J Nucl Med 1982; 23:978), with a continuing rate of 2% to 3% per year thereafter. Cancer: Page 703 “One report from the Co-operative Thyrotoxicosis follow up study, with a mean length of 21 years, did find an excess risk of death from thyroid carcinoma in patients receiving RAI for hyperthyroidism due to toxic multinodular goiter (262 Ron E, Doody MM, Becker DV, et al. Cancer mortality following treatment for adult hyperthyroidism. JAMA 1998: 280; 347). Page 704 Exposure of the rest of the body to RAI 131-I. “The whole body is exposed to radiation after RAI therapy with gonadal radiation of particular concern because of gamma irradiation from RAI in urinary bladder” Eyes: Page 704 -705. “Based on these results, patients with Graves’ thyrotoxicosis should be counselled that eye disease is more likely to occur after radioiodine therapy than antithyroid drug (or surgical) therapy. They should also be counselled about the risks and benefits of adjunctive glucocorticoid therapy. " Alot of the stuff I've been reading seems to imply that the risk of complications or cancer caused by RAI is not very big compared to the risk of leaving hyperthyroidism untreated. This always seems a bit of an odd thing to say to me, as no-one thinks it should be left untreated, just that there are more appropriate and less drastic measures that should be taken instead, or at the very least first before subjecting the individual to RAI! Enough from me, cheers DAWN ROSE _________________________________________________________________ MSN Photos is the easiest way to share and print your photos: http://photos.msn.com/support/worldwide.aspx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2002 Report Share Posted February 21, 2002 Hi Dawn Thank you for this wealth of information. I have saved it and printed it out. Thank you all for the on going support. Sue At 11:51 AM 21/02/2002 +0000, you wrote: >Here's some more References for the top 20! > > >FROM: Werner and Ingbar’s The Thyroid A Fundamental and Clinical Text, >Eighth Edition. > >Page 703 >Hypothyroidism: >“Hypothyroidism may be considered an inevitable consequence of RAI therapy, >rather than a side effect” This section goes on to state that Hypothyroidism >may develop in as many as 90% of patients within the first year after >therapy (Ref 243 Cunnien AJ, Hay ID, Gorman CA et al. Radioiodine induced >hypothyroidism in Graves’ disease: factors associated with the increasing >incidence. J Nucl Med 1982; 23:978), with a continuing rate of 2% to 3% per >year thereafter. > >Cancer: Page 703 >“One report from the Co-operative Thyrotoxicosis follow up study, with a >mean length of 21 years, did find an excess risk of death from thyroid >carcinoma in patients receiving RAI for hyperthyroidism due to toxic >multinodular goiter (262 Ron E, Doody MM, Becker DV, et al. Cancer mortality >following treatment for adult hyperthyroidism. JAMA 1998: 280; 347). > >Page 704 >Exposure of the rest of the body to RAI 131-I. >“The whole body is exposed to radiation after RAI therapy with gonadal >radiation of particular concern because of gamma irradiation from RAI in >urinary bladder” > >Eyes: >Page 704 -705. >“Based on these results, patients with Graves’ thyrotoxicosis should be >counselled that eye disease is more likely to occur after radioiodine >therapy than antithyroid drug (or surgical) therapy. They should also be >counselled about the risks and benefits of adjunctive glucocorticoid >therapy. " > >Alot of the stuff I've been reading seems to imply that the risk of >complications or cancer caused by RAI is not very big compared to the risk >of leaving hyperthyroidism untreated. This always seems a bit of an odd >thing to say to me, as no-one thinks it should be left untreated, just that >there are more appropriate and less drastic measures that should be taken >instead, or at the very least first before subjecting the individual to RAI! > >Enough from me, cheers >DAWN ROSE > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2002 Report Share Posted February 21, 2002 Hi Dawn Thank you for this wealth of information. I have saved it and printed it out. Thank you all for the on going support. Sue At 11:51 AM 21/02/2002 +0000, you wrote: >Here's some more References for the top 20! > > >FROM: Werner and Ingbar’s The Thyroid A Fundamental and Clinical Text, >Eighth Edition. > >Page 703 >Hypothyroidism: >“Hypothyroidism may be considered an inevitable consequence of RAI therapy, >rather than a side effect” This section goes on to state that Hypothyroidism >may develop in as many as 90% of patients within the first year after >therapy (Ref 243 Cunnien AJ, Hay ID, Gorman CA et al. Radioiodine induced >hypothyroidism in Graves’ disease: factors associated with the increasing >incidence. J Nucl Med 1982; 23:978), with a continuing rate of 2% to 3% per >year thereafter. > >Cancer: Page 703 >“One report from the Co-operative Thyrotoxicosis follow up study, with a >mean length of 21 years, did find an excess risk of death from thyroid >carcinoma in patients receiving RAI for hyperthyroidism due to toxic >multinodular goiter (262 Ron E, Doody MM, Becker DV, et al. Cancer mortality >following treatment for adult hyperthyroidism. JAMA 1998: 280; 347). > >Page 704 >Exposure of the rest of the body to RAI 131-I. >“The whole body is exposed to radiation after RAI therapy with gonadal >radiation of particular concern because of gamma irradiation from RAI in >urinary bladder” > >Eyes: >Page 704 -705. >“Based on these results, patients with Graves’ thyrotoxicosis should be >counselled that eye disease is more likely to occur after radioiodine >therapy than antithyroid drug (or surgical) therapy. They should also be >counselled about the risks and benefits of adjunctive glucocorticoid >therapy. " > >Alot of the stuff I've been reading seems to imply that the risk of >complications or cancer caused by RAI is not very big compared to the risk >of leaving hyperthyroidism untreated. This always seems a bit of an odd >thing to say to me, as no-one thinks it should be left untreated, just that >there are more appropriate and less drastic measures that should be taken >instead, or at the very least first before subjecting the individual to RAI! > >Enough from me, cheers >DAWN ROSE > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2002 Report Share Posted February 21, 2002 Hi Dawn Thank you for this wealth of information. I have saved it and printed it out. Thank you all for the on going support. Sue At 11:51 AM 21/02/2002 +0000, you wrote: >Here's some more References for the top 20! > > >FROM: Werner and Ingbar’s The Thyroid A Fundamental and Clinical Text, >Eighth Edition. > >Page 703 >Hypothyroidism: >“Hypothyroidism may be considered an inevitable consequence of RAI therapy, >rather than a side effect” This section goes on to state that Hypothyroidism >may develop in as many as 90% of patients within the first year after >therapy (Ref 243 Cunnien AJ, Hay ID, Gorman CA et al. Radioiodine induced >hypothyroidism in Graves’ disease: factors associated with the increasing >incidence. J Nucl Med 1982; 23:978), with a continuing rate of 2% to 3% per >year thereafter. > >Cancer: Page 703 >“One report from the Co-operative Thyrotoxicosis follow up study, with a >mean length of 21 years, did find an excess risk of death from thyroid >carcinoma in patients receiving RAI for hyperthyroidism due to toxic >multinodular goiter (262 Ron E, Doody MM, Becker DV, et al. Cancer mortality >following treatment for adult hyperthyroidism. JAMA 1998: 280; 347). > >Page 704 >Exposure of the rest of the body to RAI 131-I. >“The whole body is exposed to radiation after RAI therapy with gonadal >radiation of particular concern because of gamma irradiation from RAI in >urinary bladder” > >Eyes: >Page 704 -705. >“Based on these results, patients with Graves’ thyrotoxicosis should be >counselled that eye disease is more likely to occur after radioiodine >therapy than antithyroid drug (or surgical) therapy. They should also be >counselled about the risks and benefits of adjunctive glucocorticoid >therapy. " > >Alot of the stuff I've been reading seems to imply that the risk of >complications or cancer caused by RAI is not very big compared to the risk >of leaving hyperthyroidism untreated. This always seems a bit of an odd >thing to say to me, as no-one thinks it should be left untreated, just that >there are more appropriate and less drastic measures that should be taken >instead, or at the very least first before subjecting the individual to RAI! > >Enough from me, cheers >DAWN ROSE > > Quote Link to comment Share on other sites More sharing options...
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