Re: Naltexone pill in water

[Guest guest]

This message seems to me to be a little misleading by what it omits.

> Abboud Et Al describes a method in which 50 mg tablets were crushed

> and dissolved in 50 mls of water, thus providing a solution

> containing 1 mg/ ml. This was administered by adding 4 ml of syrup

> per ml of solution. The resulting suspension was found to remain

> stable for up to 24h.

This information is of limited use. It affirms that the liquid method is

effective for up to one day.

> Individual samples were then tested, for five consecutive days,

> assessing changes in colour, clarity, crystal formation and pH.

> There were no changes in any of these criteria. In addition, there

> were no significant changes in naltrexone concentration. It was thus

> concluded that this preparation was stable, at room temperature, for

> a period of five days.

Here we see that the liquid prepared is stable for at least 5 days.

> Fawcett et al examined the stability of crushed tablets in ascorbic

> acid 0.5%, sodium benzoate 0.1%, glycerol 20%, with distilled,

> deionised water to 100%. Crushed tablets or powder were triturated

> with the ascorbic acid and sodium benzoate, glycerol was added to

> form a paste and the mixture was made up to volume with water.

> Stability studies on this mixture indicated that the liquid was

> chemically stable, for up to 60 days, when stored in the dark at 4°

> C.

Here the solution is shown to be stable for up to 60 days. In each of these

studies, no information is reported for what the solution would do at different

temperatures or over longer periods of time than those reported. It may be that

the solutions are stable for 90 days or at room temperature. The information

therefore is interesting but tells only part of the story.

Thank you for this interesting information.

>>

Kennard

1319 Buccaneer Dr

Salt Lake City, UT 84116

(801)951-1392

www.nathankennard.com

[Guest guest]

Seems like a waste, and conflicts with an earlier post that

naltrexone loses no potency in water. I guess we'll keep on guessing!

>

> Dissolving Naltexone pill in water, and keeping it for 10 or more

> days in a fridge, you get nothing more than its bitterness. I'm

not

> allowed to upload a file with information, so it follows this

> message. Personally I crush the pill, divide it in to 4 – that is

> the best I can do-, and dilute a part each day in to 12,5ml of

> water, take 4,5ml and throw the rest. 14 pills cost me 37 € and

last

> for 56 days. When I was buying LDN from pharmacy the cost was 60 €

> for 30 days.

> Here is the file that wanted to upload.

>

> Preparation of Low-dose Naltrexone Suspension for use in the

> Treatment

> of Multiple Sclerosis

>

> The following details are derived from information provided by

> Dupont Pharmaceuticals Ltd.

> There are described a number of formulations used by individual

> researchers not directly employed by Dupont Ltd.

>

> Abboud Et Al describes a method in which 50 mg tablets were

crushed

> and dissolved in 50 mls of water, thus providing a solution

> containing 1 mg/ ml. This was administered by adding 4 ml of syrup

> per ml of solution. The resulting suspension was found to remain

> stable for up to 24h.

>

> Tsang and Holtsman studied the stability of Naltrexone in simple

> syrup at a concentration of 1 mg/ ml. The suspension was prepared

by

> crushing three 50 mg tablets and dissolving these in 100 mls of

> distilled water and 40 mls of simple syrup.

>

> Individual samples were then tested, for five consecutive days,

> assessing changes in colour, clarity, crystal formation and pH.

> There were no changes in any of these criteria. In addition, there

> were no significant changes in naltrexone concentration. It was

thus

> concluded that this preparation was stable, at room temperature,

for

> a period of five days.

>

> Fawcett et al examined the stability of crushed tablets in

ascorbic

> acid 0.5%, sodium benzoate 0.1%, glycerol 20%, with distilled,

> deionised water to 100%. Crushed tablets or powder were triturated

> with the ascorbic acid and sodium benzoate, glycerol was added to

> form a paste and the mixture was made up to volume with water.

>

> Stability studies on this mixture indicated that the liquid was

> chemically stable, for up to 60 days, when stored in the dark at

4°

> C.

>

> Further studies, using commercial syrup suspensions, containing

> suitable antioxidants and preservatives, have demonstrated an

> appropriate clinical response, when stored under similar

> circumstances, but no chemical analysis of the active drug has yet

> been carried out.

>

> It is therefore suggested that a suspension, using either the

method

> described by Fawcett, or a suitable commercial preparation, might

be

> utilised in the preparation of a syrup suspension. This mixture

> would contain one 50 mg tablet of naltrexone in 330 ml (providing

> 1.5mg/ 10 ml dose) or two 50 mg tablets of naltrexone in 330 ml

> (providing 3 mg/ 10 ml dose).

>

> Dr M R Lawrence MRCS; LRCP

> Dietary Research Ltd

>

[Guest guest]

A couple of years ago one of the pharmacists then on the group looked up

his reference 'bible' which said naltrexone was stable in (distilled?)

water for up to a month (I can't remember now if it had to be

refrigerated to achieve that).

davizona2000 wrote:

>Seems like a waste, and conflicts with an earlier post that

>naltrexone loses no potency in water. I guess we'll keep on guessing!

>

>

[Guest guest]

It would be nice to know for sure. I'm going with the premise that it IS stable, at least long enough to be effective until you mix a new batch. I'm obviously not the only one who is depending on this. Perhaps knows because of her relationship with Dr. Bihari.

Re: [low dose naltrexone] Re: Naltexone pill in water

A couple of years ago one of the pharmacists then on the group looked up his reference 'bible' which said naltrexone was stable in (distilled?) water for up to a month (I can't remember now if it had to be refrigerated to achieve that).davizona2000 wrote:>Seems like a waste, and conflicts with an earlier post that >naltrexone loses no potency in water. I guess we'll keep on guessing!> >

[Guest guest]

For me, it has been stable when refrigerated as measured by effectiveness for 11 to 18 days, or for at least the time it takes me to consume a 50 mg pill either at 3 or 4.5 mg per night.

[Guest guest]

Thx ,

Do you fluctuate between doses too? I find myself backing off a little when I feel a little stiff the next day, but ramping back up again. I think that's one of the conveniences of making it yourself. I think you're right, I just dont think it sits in water long enough to have much of an effect on it.

Re: [low dose naltrexone] Re: Naltexone pill in water

For me, it has been stable when refrigerated as measured by effectiveness for 11 to 18 days, or for at least the time it takes me to consume a 50 mg pill either at 3 or 4.5 mg per night.

[Guest guest]

Dave,

> Do you fluctuate between doses too?

No. At present I take 4.5 mg / night. Since I began, however, I have taken between 3 and 6 at various times. In the end, 6 interrupted my sleep too much so I came back and have stayed at 4.5. I prefer the liquid method to others not because I can't get a prescription, the neuro I saw gave me the script when I asked for it. I have chosen the liquid method because I just like it this way.

[Guest guest]

Naltrexone Stability: Every drug I've worked with loses stability once it's dissolved in anything. Even simple molecules dissolved in methanol and stored at 5F lose stability in a matter of weeks / small number of months. Typically something dissolved in water and stored in a fridge (5C) will last 2 to 3 weeks. The 11-18 day stability listed in this thread is a reasonable expiration based on my experience with other drugs. The post also mentions making solutions in "syrups". This is probably a sweet solution to cover the taste of the API (active ingredient). The citric acid will lower the pH and discourage critters from growing in the mixture. Sodium Benzoate is another preservative (read the label of one of my weakneses, Ding-Dongs, or other fine foods) and look for sodium benzoate. Once these ingredients are added, the data no longer applies to a simple aqueous

solution.

Sneak preview the all-new .com. It's not radically different. Just radically better.

[Guest guest]

Thx, that helps!

>

> Naltrexone Stability:

>

> Every drug I've worked with loses stability once it's dissolved

in anything. Even simple molecules dissolved in methanol and stored

at 5F lose stability in a matter of weeks / small number of months.

Typically something dissolved in water and stored in a fridge (5C)

will last 2 to 3 weeks. The 11-18 day stability listed in this

thread is a reasonable expiration based on my experience with other

drugs.

>

> The post also mentions making solutions in " syrups " . This is

probably a sweet solution to cover the taste of the API (active

ingredient). The citric acid will lower the pH and discourage

critters from growing in the mixture. Sodium Benzoate is another

preservative (read the label of one of my weakneses, Ding-Dongs, or

other fine foods) and look for sodium benzoate. Once these

ingredients are added, the data no longer applies to a simple

aqueous solution.

>

>

>

>

> ---------------------------------

> Sneak preview the all-new .com. It's not radically

different. Just radically better.

>