RE: pdf: Immune hyperstimulation --> Autoimmunity via CD4

[Guest guest]

,

I wonder how credible this article can be to the medical community...

This explains in part what parents keep saying about how their children were ok

until they received some vaccinations.

Happy New Year!

JR

To: csb-autism-rx

From: binstock@...

Date: Thu, 31 Dec 2009 14:56:09 -0700

Subject: pdf: Immune hyperstimulation --> Autoimmunity via CD4

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008382?utm_s\

ource=feedburner & utm_medium=feed & utm_campaign=Feed%3A+plosone%2FPLoSONE+%28PLoS+\

ONE+Alerts%3A+New+Articles%29

Methodology/Principal Findings

Repeated immunization with antigen causes systemic autoimmunity in mice

otherwise not prone to spontaneous autoimmune diseases. Overstimulation

of CD4^+ T cells led to the development of autoantibody-inducing CD4^+ T

(/ai/CD4^+ T) cell which had undergone T cell receptor (TCR) revision

and was capable of inducing autoantibodies. The /ai/CD4^+ T cell was

induced by /de novo/ TCR revision but not by cross-reaction, and

subsequently overstimulated CD8^+ T cells, driving them to become

antigen-specific cytotoxic T lymphocytes (CTL). These CTLs could be

further matured by antigen cross-presentation, after which they caused

autoimmune tissue injury akin to systemic lupus erythematosus (SLE).

Conclusions/Significance

Systemic autoimmunity appears to be the inevitable consequence of

over-stimulating the host's immune 'system' by repeated immunization

with antigen, to the levels that surpass system's self-organized

criticality.