Re: Inhibitory Effect of Breast Milk on Infectivity of Live Oral Rotavirus Vaccines.

[Guest guest]

" Strategies to overcome this negative effect, such as delaying

breast-feeding at the time of immunization, should be evaluated. "

Oh I can't wait, what comes next, suggesting people NOT breastfeed to make

sure the rotovirus vaccine works?.....unbelievable we live in a world where a

vaccine would even for a second be suggested as more important than nursing your

baby. That is just disgusting.

I do find it interesting, though not surprising, that USA breastmilk is lowest

in these protective agents.

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http://journals.lww.com/pidj/Abstract/publishahead/Inhibitory_Effect_of_Breast_M\

ilk_on_Infectivity_of.99301.aspx

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> Pediatr Infect Dis J. 2010 May 3. [Epub ahead of print]

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> *Inhibitory Effect of Breast Milk on Infectivity of Live Oral

> Rotavirus Vaccines.*

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> Moon SS, Wang Y, Shane AL, Nguyen T, Ray P, P, Baek LJ, Parashar

> U, Glass RI, Jiang B.

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> >From the *National Centers for Immunization and Respiratory Disease,

> Centers for Disease Control and Prevention, Atlanta, GA; daggerDivision

> of Pediatric Infectious Disease, Emory University, Atlanta, GA; double

> daggerThe National Institute of Hygiene and Epidemiology, Hanoi,

> Vietnam; section signDepartment of Pediatrics, All India Institute of

> Medical Sciences, Delhi, India; paragraph signDepartment of Pediatrics,

> Rhode Island Hospital, Providence, RI; parallelDepartment of

> Microbiology, College of Medicine, Korea University, Seoul, South Korea;

> and **Fogarty International Center, National Institutes of Health,

> Rockville, MD.

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> *Abstract*

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> BACKGROUND:: Live oral rotavirus vaccines have been less immunogenic and

> efficacious among children in poor developing countries compared with

> middle income and industrialized countries for reasons that are not yet

> completely understood. We assessed whether the neutralizing activity of

> breast milk could lower the titer of vaccine virus and explain this

> difference in vitro. METHODS:: Breast milk samples were collected from

> mothers who were breast-feeding infants 4 to 29 weeks of age (ie,

> vaccine eligible age) in India (N = 40), Vietnam (N = 77), South Korea

> (N = 34), and the United States (N = 51). We examined breast milk for

> rotavirus-specific IgA and neutralizing activity against 3 rotavirus

> vaccine strains-RV1, RV5 G1, and 116E using enzyme immunoassays. The

> inhibitory effect of breast milk on RV1 was further examined by a plaque

> reduction assay. FINDINGS:: Breast milk from Indian women had the

> highest IgA and neutralizing titers against all 3 vaccine strains, while

> lower but comparable median IgA and neutralizing titers were detected in

> breast milk from Korean and Vietnamese women, and the lowest titers were

> seen in American women. Neutralizing activity was greatest against the 2

> vaccine strains of human origin, RV1 and 116E. This neutralizing

> activity in one half of the breast milk specimens from Indian women

> could reduce the effective titer of RV1 by approximately 2 logs, of 116E

> by 1.5 logs, and RV5 G1 strain by approximately 1 log more than that of

> breast milk from American women. INTERPRETATION:: The lower

> immunogenicity and efficacy of rotavirus vaccines in poor developing

> countries could be explained, in part, by higher titers of IgA and

> neutralizing activity in breast milk consumed by their infants at the

> time of immunization that could effectively reduce the potency of the

> vaccine. >

> PMID: 20442687 [PubMed - as supplied by publisher]

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