Guest guest Posted March 19, 2007 Report Share Posted March 19, 2007 [autismnet] Digest Number 2270 > > There are 3 messages in this issue. > > Topics in this digest: > > 1. In 2003 alone there were 490,000 Premature births in USA! WHY? any > From: autismas > > 2. Study Finds Non-Inherited Autism Clue > From: schafer > > 3. SPONTANEOUS mutations do not occur unless you have " inherited > From: autismas > > > Messages > ________________________________________________________________________ > > 1. In 2003 alone there were 490,000 Premature births in USA! WHY? any > Posted by: " autismas " autismas@... autismas > Date: Sun Mar 18, 2007 3:11 pm ((PDT)) > > Now it makes me wonder if all these 490,000 had become Autistic or > have ASD Dx in 2006! > > http://images.main.uab.edu/imedpub/insight-win07.pdf > > Please read page 10 and 11 in this PDF article about NO injuring > brains. > > Did CDC or DPH or DHS ever find out why these 490,000 were birthed > prematurely? > > Perhaps it is time to look at the term " GESTATION " period very closely > and say Human Gestation period is only for 23 weeks inside womb! I say > this mainly because the age at which little girls attain " PUBERTY " has > come down. Some girls are having periods at age 9yrs in USA! So why > can't the gestation period be reduced as well? Global warming has > definitely something to do w it. BUT I am not very sure. > > If all those 490,000 premies survived and how many became autistic now? > > IS there any study on this at all? I was shocked to learn about 490K > cases of premature births. What factors trigger early labor in a > pregnant woman and why? > > How can you prevent it? It is not cost effect to have those premies > inNICU for parents would miss out being " real parents " when they can't > take thier delivered fetuses home right away. > > Autism can occur in Premies for various genetic and post natal > environmental reasons or triggers. > > Dad4kids perhaps has an answer or two for me to explain this to me now. > > Please reply. Thanks. > > > > > Messages in this topic (1) > ________________________________________________________________________ > ________________________________________________________________________ > > 2. Study Finds Non-Inherited Autism Clue > Posted by: " schafer " schafer@... schaferatsprynet > Date: Mon Mar 19, 2007 1:12 am ((PDT)) > > > SAR " Healing Autism: > Schafer Autism Report No Finer a Cause on the Planet " > ________________________________________________________________ > Monday, March 19, 2007 Vol. 11 No. 41p > > > > >> PROMOTE YOUR 2007 EVENTS NOW - FREE << > Conferences * Presentations * Parent Meetings > DEADLINE FOR APRIL AUTISM CALENDAR IS > March 23 THIS FRIDAY! > > Submit listing here: > http://www.sarnet.org/frm/cal-frm.htm > CHECK OUT CALENDAR: http://www.sarnet.org/events/ > > > > RESEARCH > * Study Finds Non-Inherited Autism Clue > > TREATMENT > * Ped Med: Behavior Therapy For Autism > > CARE > * Boy Found Dead In Pond, GA > * Woman Dies After Mass. Cops Restrain Her > > ADVOCACY > * land Effort to Limit Mercury Presses Forward > * Legislation Would Create Agency To Help CT Autistic Children > * Insurance Industry Opposes WI Autism Funding Proposal > * Autism: Funding Could Alleviate NM Families' Frustration > > MEDIA > * MTV Offers Teenage View of Life With Autism > * Autism One Radio - Norm Schwartz MD: Biomedical Basics - > Autism is Treatable > * NY Times Video: Coping With Epilepsy > > LETTERS > * On the SAR Depublishing of " Autism: It's Not Just in the Head " > > > For rest of today's SAR click here: http://www.sarnet.org/frm/forsar.htm > (This link updates daily.) > > For missed editions see archive: > http://health.groups.yahoo.com/group/-AuTeach/messages > > _______________________________________________ > SARnets mailing list > SARnets@... > http://lists.igc.org/mailman/listinfo/sarnets > You can unsubscribe send email: > http://www.sarnet.org/frm/unsub2.htm > -- > You are subscribed as: > autismnet > > > Messages in this topic (1) > ________________________________________________________________________ > ________________________________________________________________________ > > 3. SPONTANEOUS mutations do not occur unless you have " inherited > Posted by: " autismas " autismas@... autismas > Date: Mon Mar 19, 2007 7:18 am ((PDT)) > > " Study finds non-inherited autism clue > > By Talan > Newsday > March 17, 2007 > > Putting the pieces of the complex puzzle of autism together bit by > genetic bit, scientists at Cold Spring Harbor Laboratory in New York > have identified dozens of spontaneous mutations that lead to a common > pathway to the brain disorder. > > Until recently, scientists have been looking for several specific > genes that run in families, which could help explain why some > children are born with autism. Last month, the Centers for Disease > Control and Prevention announced that 1 in 150 children are born with > autism. > > In this new study, published Friday in Science, Sebat, > Wigler and their colleagues found that 10 percent of the 195 > autistic patients they studied had evidence of tiny ****spontaneous > chromosomal mutations - each with a different gene involved. > Ultimately, Sebat said he believes this could help some parents who > are seeking to have more children but fearful that they will take > another genetic hit with their next child. > > A spontaneous mutation means it is not inherited. > > According to Sebat, an associate professor of genetics at the Long > Island research lab, technology until now could not provide enough > resolution to see many of these small chromosomal abnormalities. > > Humans have 23 pairs of chromosomes, which include a pair of sex > chromosomes. People differ substantially in the chromosomal structure > and can have repeats or deletions in stretches of the DNA, according > to earlier work by the same team. > > Scientists are not sure why. > > " In autism, there are a certain number of individuals who have more > variation in the number of copies of genes, " said Pat Levitt, > director of the Vanderbilt Kennedy Center in Tennessee and an expert > on autism who is not involved in the study. " This is an important > finding. " > > In blood samples from the autistic patients and an equal number of > unaffected siblings and parents, 10 percent of them had spontaneous > genetic mutations compared with 1 percent of those in a control > group. In families with more than one autistic child, there were very > few of these spontaneous chromosomal rearrangements. It's akin to a > reshuffling of the chromosomes. > > But what was most surprising is that all of the mutations appeared at > different places along the genome, suggesting, as Sebat said, " that > there are *****so many possible places where you can get a hit. " > > The end result of these genetic mutations is that these children have > impaired social interactions, difficulty communicating, restricted > interests and language deficits. > > " The brain has a particular way of responding to many different types > of cognitive impairment, " Sebat said. > > The scientists will figure out what each of these genes do, so a > common theme might emerge to explain autism, Sebat said. The work was > done in collaboration with others at Cold Spring Harbor as well as > Geschwind of the University of California, Los Angeles and > scientists at institutions around the world. > > " These are rare changes, dispersed across the genome. They tell us > that autism may be the final common path for many different genetic > abnormalities, " said Dr. Insel, director of the National > Institute of Mental Health. The samples used in the study came from > the Autism Genetic Resource Exchange and the institute's Center for > Collaborative Genetic Studies of Mental Disorders " . > ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ > Q: Why would " TINY mutations " occur only in some kids' genomes? Esp > more in BOYS than in girls to manifest AUTISM? > > Q: If all parents in a given community purchased food or water or > whatever consumer items from shared environmental sources, how come > only 1:150 infants later produce Autistic Disorder? > > Q: What does Spontaneous mutations mean? How can it be spontanoeus > when every factor trigger (including vaccines) are offered to > parents/kids in a controlled environmental protocol? Meaning, people > know where their grocers are or pharmacies are located or when their > children will receive vaccines on a schedule etc. This does not make > any sense to me. I could be wrong. > > Q: Does it take one Trigger to attack many spots in a genome or many > triggers hitting many sequences in a DNA? > > Q: How many of you really believe this story? > I don't. Mutations can occur. BUT if the genome was strong and not > vulnerable then no trigger can affect it. > > Q: What was the condition/s of these kids' genome prior to their > birth or during prenatal time? No one has any studies on it. > > Q: Did all those 490,000 premies get ASD or did they die after > delivery? Who has info on that? > > In lay man's terms there are two things: > Recessive genes= PREDISPOSITION. > Dominant Genes= SUSCEPTIBILITY. > > Spontaneous mutations if occurred prior to birth because of exposure, > those genes may become " RECESSIVE " first, before another trigger/s > hit the same to make it very " SUSCEPTIBLE " aka DOMINANT. > Vulnearbility for certain specific conditions is always inherited, in > MHO. That is how I feel inside about this whole thing on Autism. > > Between Recessive mode and dominant mode, there may be a lot of > interactions that we don't know. It could have occurred prenatally or > even before a fetus was conceived. Recessive and Dominant > presentation of Genes just reveal the degree of VULNEARABILITY only. > Vulnearable for good traits or bad traits that is. > > The BOTTOM LINE is: You have to have an inherited " SUSCEPTIBILITY " to > produce kids w this major disorder. Otherwise, it simply does not > occur. > > o, well. > > Hey Dad4kids, what do ya think? > > > > Messages in this topic (1) > ________________________________________________________________________ > ________________________________________________________________________ > > > > ------------------------------------------------------------------------ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 19, 2007 Report Share Posted March 19, 2007 My mother was 9 when she had her first period she would have been 64 this year. My 1st child was born at 34 weeks he is typical, my second child tried to come at 27 weeks but we held off with terbutaline and bed rest he is PDD/NOS or autistic moderate depending on which doctor you talk to, my 3rd child was induced at 38 weeks she had 2 holes in her heart (which I learned her grandmother also had) and she is dyslexic but otherwise fine. My husband was 30 when we had our autistic child we don't watch more TV than most and I'm very artistic and my husband is a math whiz and can be quiet and thoughtful around strangers...I am the complete opposite. I don't think autism has anything to do with gestation or global warming or better diagnosis but I do think there is some kind of trigger to genetically susceptible people. Nearly all the boys in my family (both sides) have speech disorders or ADD/ADHD or anxiety none of them in at least 3 generations are autistic except my now 12 year old. It's enough to make you lose many hours of sleep trying to undo what has been done. At least after all this time I am relatively sure it's not because I am a bad mother, that we watch to many videos or that my husband is too old or the ice plate is shifting. I hope that helps, I hope I'm wrong and it was something as simple as me doing something stupid at least it would be something I expected. Ha! LOL Trina > > > [autismnet] Digest Number 2270 > > > > > There are 3 messages in this issue. > > > > Topics in this digest: > > > > 1. In 2003 alone there were 490,000 Premature births in USA! WHY? any > > From: autismas > > > > 2. Study Finds Non-Inherited Autism Clue > > From: schafer > > > > 3. SPONTANEOUS mutations do not occur unless you have " inherited > > From: autismas > > > > > > Messages > > __________________________________________________________ > > > > 1. In 2003 alone there were 490,000 Premature births in USA! WHY? any > > Posted by: " autismas " autismas@... > <mailto:autismas%40yahoo.com> autismas > > Date: Sun Mar 18, 2007 3:11 pm ((PDT)) > > > > Now it makes me wonder if all these 490,000 had become Autistic or > > have ASD Dx in 2006! > > > > http://images.main.uab.edu/imedpub/insight-win07.pdf > <http://images.main.uab.edu/imedpub/insight-win07.pdf> > > > > Please read page 10 and 11 in this PDF article about NO injuring > > brains. > > > > Did CDC or DPH or DHS ever find out why these 490,000 were birthed > > prematurely? > > > > Perhaps it is time to look at the term " GESTATION " period very closely > > and say Human Gestation period is only for 23 weeks inside womb! I say > > this mainly because the age at which little girls attain " PUBERTY " has > > come down. Some girls are having periods at age 9yrs in USA! So why > > can't the gestation period be reduced as well? Global warming has > > definitely something to do w it. BUT I am not very sure. > > > > If all those 490,000 premies survived and how many became autistic now? > > > > IS there any study on this at all? I was shocked to learn about 490K > > cases of premature births. What factors trigger early labor in a > > pregnant woman and why? > > > > How can you prevent it? It is not cost effect to have those premies > > inNICU for parents would miss out being " real parents " when they can't > > take thier delivered fetuses home right away. > > > > Autism can occur in Premies for various genetic and post natal > > environmental reasons or triggers. > > > > Dad4kids perhaps has an answer or two for me to explain this to me now. > > > > Please reply. Thanks. > > > > > > > > > > Messages in this topic (1) > > __________________________________________________________ > > __________________________________________________________ > > > > 2. Study Finds Non-Inherited Autism Clue > > Posted by: " schafer " schafer@... > <mailto:schafer%40sprynet.com> schaferatsprynet > > Date: Mon Mar 19, 2007 1:12 am ((PDT)) > > > > > > SAR " Healing Autism: > > Schafer Autism Report No Finer a Cause on the Planet " > > __________________________________________________________ > > Monday, March 19, 2007 Vol. 11 No. 41p > > > > > > > > >> PROMOTE YOUR 2007 EVENTS NOW - FREE << > > Conferences * Presentations * Parent Meetings > > DEADLINE FOR APRIL AUTISM CALENDAR IS > > March 23 THIS FRIDAY! > > > > Submit listing here: > > http://www.sarnet.org/frm/cal-frm.htm > <http://www.sarnet.org/frm/cal-frm.htm> > > CHECK OUT CALENDAR: http://www.sarnet.org/events/ > <http://www.sarnet.org/events/> > > > > > > > > RESEARCH > > * Study Finds Non-Inherited Autism Clue > > > > TREATMENT > > * Ped Med: Behavior Therapy For Autism > > > > CARE > > * Boy Found Dead In Pond, GA > > * Woman Dies After Mass. Cops Restrain Her > > > > ADVOCACY > > * land Effort to Limit Mercury Presses Forward > > * Legislation Would Create Agency To Help CT Autistic Children > > * Insurance Industry Opposes WI Autism Funding Proposal > > * Autism: Funding Could Alleviate NM Families' Frustration > > > > MEDIA > > * MTV Offers Teenage View of Life With Autism > > * Autism One Radio - Norm Schwartz MD: Biomedical Basics - > > Autism is Treatable > > * NY Times Video: Coping With Epilepsy > > > > LETTERS > > * On the SAR Depublishing of " Autism: It's Not Just in the Head " > > > > > > For rest of today's SAR click here: > http://www.sarnet.org/frm/forsar.htm > <http://www.sarnet.org/frm/forsar.htm> > > (This link updates daily.) > > > > For missed editions see archive: > > http://health.groups.yahoo.com/group/-AuTeach/messages > <http://health.groups.yahoo.com/group/-AuTeach/messages> > > > > _______________________________________________ > > SARnets mailing list > > SARnets@... <mailto:SARnets%40lists.igc.org> > > http://lists.igc.org/mailman/listinfo/sarnets > <http://lists.igc.org/mailman/listinfo/sarnets> > > You can unsubscribe send email: > > http://www.sarnet.org/frm/unsub2.htm > <http://www.sarnet.org/frm/unsub2.htm> > > -- > > You are subscribed as: > > autismnet <mailto:autismnet%40yahoogroups.com> > > > > > > Messages in this topic (1) > > __________________________________________________________ > > __________________________________________________________ > > > > 3. SPONTANEOUS mutations do not occur unless you have " inherited > > Posted by: " autismas " autismas@... > <mailto:autismas%40yahoo.com> autismas > > Date: Mon Mar 19, 2007 7:18 am ((PDT)) > > > > " Study finds non-inherited autism clue > > > > By Talan > > Newsday > > March 17, 2007 > > > > Putting the pieces of the complex puzzle of autism together bit by > > genetic bit, scientists at Cold Spring Harbor Laboratory in New York > > have identified dozens of spontaneous mutations that lead to a common > > pathway to the brain disorder. > > > > Until recently, scientists have been looking for several specific > > genes that run in families, which could help explain why some > > children are born with autism. Last month, the Centers for Disease > > Control and Prevention announced that 1 in 150 children are born with > > autism. > > > > In this new study, published Friday in Science, Sebat, > > Wigler and their colleagues found that 10 percent of the 195 > > autistic patients they studied had evidence of tiny ****spontaneous > > chromosomal mutations - each with a different gene involved. > > Ultimately, Sebat said he believes this could help some parents who > > are seeking to have more children but fearful that they will take > > another genetic hit with their next child. > > > > A spontaneous mutation means it is not inherited. > > > > According to Sebat, an associate professor of genetics at the Long > > Island research lab, technology until now could not provide enough > > resolution to see many of these small chromosomal abnormalities. > > > > Humans have 23 pairs of chromosomes, which include a pair of sex > > chromosomes. People differ substantially in the chromosomal structure > > and can have repeats or deletions in stretches of the DNA, according > > to earlier work by the same team. > > > > Scientists are not sure why. > > > > " In autism, there are a certain number of individuals who have more > > variation in the number of copies of genes, " said Pat Levitt, > > director of the Vanderbilt Kennedy Center in Tennessee and an expert > > on autism who is not involved in the study. " This is an important > > finding. " > > > > In blood samples from the autistic patients and an equal number of > > unaffected siblings and parents, 10 percent of them had spontaneous > > genetic mutations compared with 1 percent of those in a control > > group. In families with more than one autistic child, there were very > > few of these spontaneous chromosomal rearrangements. It's akin to a > > reshuffling of the chromosomes. > > > > But what was most surprising is that all of the mutations appeared at > > different places along the genome, suggesting, as Sebat said, " that > > there are *****so many possible places where you can get a hit. " > > > > The end result of these genetic mutations is that these children have > > impaired social interactions, difficulty communicating, restricted > > interests and language deficits. > > > > " The brain has a particular way of responding to many different types > > of cognitive impairment, " Sebat said. > > > > The scientists will figure out what each of these genes do, so a > > common theme might emerge to explain autism, Sebat said. The work was > > done in collaboration with others at Cold Spring Harbor as well as > > Geschwind of the University of California, Los Angeles and > > scientists at institutions around the world. > > > > " These are rare changes, dispersed across the genome. They tell us > > that autism may be the final common path for many different genetic > > abnormalities, " said Dr. Insel, director of the National > > Institute of Mental Health. The samples used in the study came from > > the Autism Genetic Resource Exchange and the institute's Center for > > Collaborative Genetic Studies of Mental Disorders " . > > ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ > > Q: Why would " TINY mutations " occur only in some kids' genomes? Esp > > more in BOYS than in girls to manifest AUTISM? > > > > Q: If all parents in a given community purchased food or water or > > whatever consumer items from shared environmental sources, how come > > only 1:150 infants later produce Autistic Disorder? > > > > Q: What does Spontaneous mutations mean? How can it be spontanoeus > > when every factor trigger (including vaccines) are offered to > > parents/kids in a controlled environmental protocol? Meaning, people > > know where their grocers are or pharmacies are located or when their > > children will receive vaccines on a schedule etc. This does not make > > any sense to me. I could be wrong. > > > > Q: Does it take one Trigger to attack many spots in a genome or many > > triggers hitting many sequences in a DNA? > > > > Q: How many of you really believe this story? > > I don't. Mutations can occur. BUT if the genome was strong and not > > vulnerable then no trigger can affect it. > > > > Q: What was the condition/s of these kids' genome prior to their > > birth or during prenatal time? No one has any studies on it. > > > > Q: Did all those 490,000 premies get ASD or did they die after > > delivery? Who has info on that? > > > > In lay man's terms there are two things: > > Recessive genes= PREDISPOSITION. > > Dominant Genes= SUSCEPTIBILITY. > > > > Spontaneous mutations if occurred prior to birth because of exposure, > > those genes may become " RECESSIVE " first, before another trigger/s > > hit the same to make it very " SUSCEPTIBLE " aka DOMINANT. > > Vulnearbility for certain specific conditions is always inherited, in > > MHO. That is how I feel inside about this whole thing on Autism. > > > > Between Recessive mode and dominant mode, there may be a lot of > > interactions that we don't know. It could have occurred prenatally or > > even before a fetus was conceived. Recessive and Dominant > > presentation of Genes just reveal the degree of VULNEARABILITY only. > > Vulnearable for good traits or bad traits that is. > > > > The BOTTOM LINE is: You have to have an inherited " SUSCEPTIBILITY " to > > produce kids w this major disorder. Otherwise, it simply does not > > occur. > > > > o, well. > > > > Hey Dad4kids, what do ya think? > > > > > > > > Messages in this topic (1) > > __________________________________________________________ > > __________________________________________________________ > > > > > > > > ---------------------------------------------------------- > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 19, 2007 Report Share Posted March 19, 2007 My mother was 9 when she had her first period she would have been 64 this year. My 1st child was born at 34 weeks he is typical, my second child tried to come at 27 weeks but we held off with terbutaline and bed rest he is PDD/NOS or autistic moderate depending on which doctor you talk to, my 3rd child was induced at 38 weeks she had 2 holes in her heart (which I learned her grandmother also had) and she is dyslexic but otherwise fine. My husband was 30 when we had our autistic child we don't watch more TV than most and I'm very artistic and my husband is a math whiz and can be quiet and thoughtful around strangers...I am the complete opposite. I don't think autism has anything to do with gestation or global warming or better diagnosis but I do think there is some kind of trigger to genetically susceptible people. Nearly all the boys in my family (both sides) have speech disorders or ADD/ADHD or anxiety none of them in at least 3 generations are autistic except my now 12 year old. It's enough to make you lose many hours of sleep trying to undo what has been done. At least after all this time I am relatively sure it's not because I am a bad mother, that we watch to many videos or that my husband is too old or the ice plate is shifting. I hope that helps, I hope I'm wrong and it was something as simple as me doing something stupid at least it would be something I expected. Ha! LOL Trina > > > [autismnet] Digest Number 2270 > > > > > There are 3 messages in this issue. > > > > Topics in this digest: > > > > 1. In 2003 alone there were 490,000 Premature births in USA! WHY? any > > From: autismas > > > > 2. Study Finds Non-Inherited Autism Clue > > From: schafer > > > > 3. SPONTANEOUS mutations do not occur unless you have " inherited > > From: autismas > > > > > > Messages > > __________________________________________________________ > > > > 1. In 2003 alone there were 490,000 Premature births in USA! WHY? any > > Posted by: " autismas " autismas@... > <mailto:autismas%40yahoo.com> autismas > > Date: Sun Mar 18, 2007 3:11 pm ((PDT)) > > > > Now it makes me wonder if all these 490,000 had become Autistic or > > have ASD Dx in 2006! > > > > http://images.main.uab.edu/imedpub/insight-win07.pdf > <http://images.main.uab.edu/imedpub/insight-win07.pdf> > > > > Please read page 10 and 11 in this PDF article about NO injuring > > brains. > > > > Did CDC or DPH or DHS ever find out why these 490,000 were birthed > > prematurely? > > > > Perhaps it is time to look at the term " GESTATION " period very closely > > and say Human Gestation period is only for 23 weeks inside womb! I say > > this mainly because the age at which little girls attain " PUBERTY " has > > come down. Some girls are having periods at age 9yrs in USA! So why > > can't the gestation period be reduced as well? Global warming has > > definitely something to do w it. BUT I am not very sure. > > > > If all those 490,000 premies survived and how many became autistic now? > > > > IS there any study on this at all? I was shocked to learn about 490K > > cases of premature births. What factors trigger early labor in a > > pregnant woman and why? > > > > How can you prevent it? It is not cost effect to have those premies > > inNICU for parents would miss out being " real parents " when they can't > > take thier delivered fetuses home right away. > > > > Autism can occur in Premies for various genetic and post natal > > environmental reasons or triggers. > > > > Dad4kids perhaps has an answer or two for me to explain this to me now. > > > > Please reply. Thanks. > > > > > > > > > > Messages in this topic (1) > > __________________________________________________________ > > __________________________________________________________ > > > > 2. Study Finds Non-Inherited Autism Clue > > Posted by: " schafer " schafer@... > <mailto:schafer%40sprynet.com> schaferatsprynet > > Date: Mon Mar 19, 2007 1:12 am ((PDT)) > > > > > > SAR " Healing Autism: > > Schafer Autism Report No Finer a Cause on the Planet " > > __________________________________________________________ > > Monday, March 19, 2007 Vol. 11 No. 41p > > > > > > > > >> PROMOTE YOUR 2007 EVENTS NOW - FREE << > > Conferences * Presentations * Parent Meetings > > DEADLINE FOR APRIL AUTISM CALENDAR IS > > March 23 THIS FRIDAY! > > > > Submit listing here: > > http://www.sarnet.org/frm/cal-frm.htm > <http://www.sarnet.org/frm/cal-frm.htm> > > CHECK OUT CALENDAR: http://www.sarnet.org/events/ > <http://www.sarnet.org/events/> > > > > > > > > RESEARCH > > * Study Finds Non-Inherited Autism Clue > > > > TREATMENT > > * Ped Med: Behavior Therapy For Autism > > > > CARE > > * Boy Found Dead In Pond, GA > > * Woman Dies After Mass. Cops Restrain Her > > > > ADVOCACY > > * land Effort to Limit Mercury Presses Forward > > * Legislation Would Create Agency To Help CT Autistic Children > > * Insurance Industry Opposes WI Autism Funding Proposal > > * Autism: Funding Could Alleviate NM Families' Frustration > > > > MEDIA > > * MTV Offers Teenage View of Life With Autism > > * Autism One Radio - Norm Schwartz MD: Biomedical Basics - > > Autism is Treatable > > * NY Times Video: Coping With Epilepsy > > > > LETTERS > > * On the SAR Depublishing of " Autism: It's Not Just in the Head " > > > > > > For rest of today's SAR click here: > http://www.sarnet.org/frm/forsar.htm > <http://www.sarnet.org/frm/forsar.htm> > > (This link updates daily.) > > > > For missed editions see archive: > > http://health.groups.yahoo.com/group/-AuTeach/messages > <http://health.groups.yahoo.com/group/-AuTeach/messages> > > > > _______________________________________________ > > SARnets mailing list > > SARnets@... <mailto:SARnets%40lists.igc.org> > > http://lists.igc.org/mailman/listinfo/sarnets > <http://lists.igc.org/mailman/listinfo/sarnets> > > You can unsubscribe send email: > > http://www.sarnet.org/frm/unsub2.htm > <http://www.sarnet.org/frm/unsub2.htm> > > -- > > You are subscribed as: > > autismnet <mailto:autismnet%40yahoogroups.com> > > > > > > Messages in this topic (1) > > __________________________________________________________ > > __________________________________________________________ > > > > 3. SPONTANEOUS mutations do not occur unless you have " inherited > > Posted by: " autismas " autismas@... > <mailto:autismas%40yahoo.com> autismas > > Date: Mon Mar 19, 2007 7:18 am ((PDT)) > > > > " Study finds non-inherited autism clue > > > > By Talan > > Newsday > > March 17, 2007 > > > > Putting the pieces of the complex puzzle of autism together bit by > > genetic bit, scientists at Cold Spring Harbor Laboratory in New York > > have identified dozens of spontaneous mutations that lead to a common > > pathway to the brain disorder. > > > > Until recently, scientists have been looking for several specific > > genes that run in families, which could help explain why some > > children are born with autism. Last month, the Centers for Disease > > Control and Prevention announced that 1 in 150 children are born with > > autism. > > > > In this new study, published Friday in Science, Sebat, > > Wigler and their colleagues found that 10 percent of the 195 > > autistic patients they studied had evidence of tiny ****spontaneous > > chromosomal mutations - each with a different gene involved. > > Ultimately, Sebat said he believes this could help some parents who > > are seeking to have more children but fearful that they will take > > another genetic hit with their next child. > > > > A spontaneous mutation means it is not inherited. > > > > According to Sebat, an associate professor of genetics at the Long > > Island research lab, technology until now could not provide enough > > resolution to see many of these small chromosomal abnormalities. > > > > Humans have 23 pairs of chromosomes, which include a pair of sex > > chromosomes. People differ substantially in the chromosomal structure > > and can have repeats or deletions in stretches of the DNA, according > > to earlier work by the same team. > > > > Scientists are not sure why. > > > > " In autism, there are a certain number of individuals who have more > > variation in the number of copies of genes, " said Pat Levitt, > > director of the Vanderbilt Kennedy Center in Tennessee and an expert > > on autism who is not involved in the study. " This is an important > > finding. " > > > > In blood samples from the autistic patients and an equal number of > > unaffected siblings and parents, 10 percent of them had spontaneous > > genetic mutations compared with 1 percent of those in a control > > group. In families with more than one autistic child, there were very > > few of these spontaneous chromosomal rearrangements. It's akin to a > > reshuffling of the chromosomes. > > > > But what was most surprising is that all of the mutations appeared at > > different places along the genome, suggesting, as Sebat said, " that > > there are *****so many possible places where you can get a hit. " > > > > The end result of these genetic mutations is that these children have > > impaired social interactions, difficulty communicating, restricted > > interests and language deficits. > > > > " The brain has a particular way of responding to many different types > > of cognitive impairment, " Sebat said. > > > > The scientists will figure out what each of these genes do, so a > > common theme might emerge to explain autism, Sebat said. The work was > > done in collaboration with others at Cold Spring Harbor as well as > > Geschwind of the University of California, Los Angeles and > > scientists at institutions around the world. > > > > " These are rare changes, dispersed across the genome. They tell us > > that autism may be the final common path for many different genetic > > abnormalities, " said Dr. Insel, director of the National > > Institute of Mental Health. The samples used in the study came from > > the Autism Genetic Resource Exchange and the institute's Center for > > Collaborative Genetic Studies of Mental Disorders " . > > ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ > > Q: Why would " TINY mutations " occur only in some kids' genomes? Esp > > more in BOYS than in girls to manifest AUTISM? > > > > Q: If all parents in a given community purchased food or water or > > whatever consumer items from shared environmental sources, how come > > only 1:150 infants later produce Autistic Disorder? > > > > Q: What does Spontaneous mutations mean? How can it be spontanoeus > > when every factor trigger (including vaccines) are offered to > > parents/kids in a controlled environmental protocol? Meaning, people > > know where their grocers are or pharmacies are located or when their > > children will receive vaccines on a schedule etc. This does not make > > any sense to me. I could be wrong. > > > > Q: Does it take one Trigger to attack many spots in a genome or many > > triggers hitting many sequences in a DNA? > > > > Q: How many of you really believe this story? > > I don't. Mutations can occur. BUT if the genome was strong and not > > vulnerable then no trigger can affect it. > > > > Q: What was the condition/s of these kids' genome prior to their > > birth or during prenatal time? No one has any studies on it. > > > > Q: Did all those 490,000 premies get ASD or did they die after > > delivery? Who has info on that? > > > > In lay man's terms there are two things: > > Recessive genes= PREDISPOSITION. > > Dominant Genes= SUSCEPTIBILITY. > > > > Spontaneous mutations if occurred prior to birth because of exposure, > > those genes may become " RECESSIVE " first, before another trigger/s > > hit the same to make it very " SUSCEPTIBLE " aka DOMINANT. > > Vulnearbility for certain specific conditions is always inherited, in > > MHO. That is how I feel inside about this whole thing on Autism. > > > > Between Recessive mode and dominant mode, there may be a lot of > > interactions that we don't know. It could have occurred prenatally or > > even before a fetus was conceived. Recessive and Dominant > > presentation of Genes just reveal the degree of VULNEARABILITY only. > > Vulnearable for good traits or bad traits that is. > > > > The BOTTOM LINE is: You have to have an inherited " SUSCEPTIBILITY " to > > produce kids w this major disorder. Otherwise, it simply does not > > occur. > > > > o, well. > > > > Hey Dad4kids, what do ya think? > > > > > > > > Messages in this topic (1) > > __________________________________________________________ > > __________________________________________________________ > > > > > > > > ---------------------------------------------------------- > > Quote Link to comment Share on other sites More sharing options...
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