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Dealing with bone mets

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I wonder if anyone has any suggestions to some questions I'm

pondering at the moment:

(1) Do bone or other PC mets also produce PSA? For instance, might

one shrink the primary tumour but still have quite a high PSA due to

on-going bone mets as shown in one's Alk Phos levels?

(2) What are the best systemic treatments for widespread bone mets?

Might the form of chemotherapy be different from say straight

Taxotere, perhaps adding Carboplatin and / or Emcyt? Perhaps

Ketokonazole? Perhaps antiangiogenesis with thalidomide or another drug?

(3) What is the best alternative triple hormone blockage to ring the

changes on zoladex - casodex - proscar? Perhaps Trelstar - Estrogen

patches - Avodart?

Thanks

Will

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