A male case of acute sarcoidosis with fever, polyarthralgia, erythema nodosum, a

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Nihon Kokyuki Gakkai Zasshi. 2005 Dec;43(12):761-5.

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[A male case of acute sarcoidosis with fever, polyarthralgia, erythema nodosum, and bilateral hilar lymphadenopathy: Lofgren's syndrome]Izumo M, Sekiya K, Sakai T, Tojima H.Department of Internal Medicine, Tokyo i Hospital.A 27-year-old man initially had low back pain and ankle arthralgia. He was admitted because fever, cough, and polyarthralgia developed and continued for three months. Chest X-ray and CT revealed bilateral hilar and mediastinal lymphadenopathy with pulmonary lesions. Furthermore, elevated serum-ACE level and noncaseating epitheloid cell granuloma obtained by TBLB confirmed the diagnosis of sarcoidosis. After hospitalization, erythema nodosum appeared and ocular involvement was demonstrated. As a result, this case fulfilled the criteria of Lofgren's syndrome (arthritis, erythema nodosum, and BHL). Lofgren's syndrome is not uncommon in European countries, but is extremely rare in Japan. So far, only six cases with Lofgren's syndrome were reported in Japan, and all were female cases. This is the first male case in Japan. Lofgren's syndrome is usually a self-limiting disease. We used steroids for this case and remission has been maintained after the beginning of the treatment for the past one year.PMID: 16457340 [PubMed - in process]

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