Re: Catching Cancer (video link) Typo correction Dr Marshall video

[Guest guest]

Sorry about the typos I didn't catch - though I did catch most of them.

However, although most of them can be interpreted fairly easily, one

might be a puzzle:

Carcinomas - 750 subjects 3-7 years, all disabling disease, only two

carcinomas and netither (should read neither) were metastatic.

Breads (should read " Breast " !) and bladder carcinoma subjects studied.

30 months just getting to stage where it's interesting.

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VDR - Vitamin D Receptor

vitamin D (1,25- dihydroxyvitamin D3) receptor

Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

Aliases & Descriptions

vitamin D (1,25- dihydroxyvitamin D3) receptor1 2

NR1I11 2 3

Nuclear receptor subfamily 1 group I member 12 3

1,25-dihydroxyvitamin D3 receptor2 3

vitamin D3 receptor2

External Ids: HGNC: 126791 Entrez Gene: 74212

Ensembl: ENSG000001114247 UniProtKB: P114733

Entrez Gene summary for VDR:

This gene encodes the nuclear hormone receptor for vitamin D3. This

receptor also functions as a receptor for the secondary bile acid

lithocholic acid. The receptor belongs to the family of trans-acting

transcriptional regulatory factors and shows sequence similarity to the

steroid and thyroid hormone receptors. Downstream targets of this

nuclear hormone receptor are principally involved in mineral metabolism

though the receptor regulates a variety of other metabolic pathways,

such as those involved in the immune response and cancer. Mutations in

this gene are associated with type II vitamin D-resistant rickets. A

single nucleotide polymorphism in the initiation codon results in an

alternate translation start site three codons downstream. Alternative

splicing results in multiple transcript variants encoding the same

protein. (provided by RefSeq)

UniProtKB/Swiss-Prot: VDR_HUMAN, P11473

Function: Nuclear hormone receptor. Transcription factor that

mediates the action of vitamin D3 by controlling the expression of

hormone sensitive genes. Regulates transcription of hormone sensitive

genes via its association with the WINAC complex, a chromatin-remodeling

complex. Recruited to promoters via its interaction with the WINAC

complex subunit BAZ1B/WSTF, which mediates the interaction with

acetylated histones, an essential step for VDR-promoter association.

Plays a central role in calcium homeostasis

" " summary for VDR:

Vitamin D receptors (VDRs) are members of the NR1I family, which

also includes pregnane X (PXR) and constitutive androstane (CAR)

receptors, that form heterodimers with members of the retinoid X

receptor family. VDR is expressed in the intestine, thyroid and kidney

and has a vital role in calcium homeostasis.

VDRs repress expression of 1alpha-hydroxylase (the proximal

activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3

inactivating enzyme CYP24. Also, it has recently been identified as an

additional bile acid receptor alongside FXR and may function to protect

gut against the toxic and carcinogenic effects of these endobiotics.

Inherited mutations in the VDR gene leads to rickets, which is

characterized by muscle weakness, growth retardation, bone deformity and

secondary hyperparathyroidism. The human gene encoding the vitamin D

receptor has been localized to chromosome 12q12-q14.

>

>

> It's a two minute trailer; the full film has " expired " but it can be

purchased.

> Intro says it might have been a mouse virus.

> Opinion expressed that more than half of human cancer may be

infection, and that when all info is in it might be over 90%.

>

> Youtube threw up a llink to Dr Trevor Marshall a video response to

the ABC video.

> http://www.youtube.com/watch?v=JXt5Ga2WqZI & NR=1

> He is one of the Helicobacter pylori microbiologists.

>

> I took some quick notes:

>